Romatoid artrit'de serum bakır, çinko ve selenyum düzeyleri

Objective & Hypothesis:The objective of this study was to measure the alterations in some important serum trace elements, including selenium (Se), zinc (Zn), copper (Cu), in patients with rheumatoid arthritis (RA).

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Key Findings & Data:In the study, serum trace elements were determined by using Atomic Absorption Spectrophotometer in sera of patients with RA (n=32), and statistically compared with healthy individuals (n=52).

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Conclusion & Impact:Our results showed that serum trace elements (Se, Zn and Cu) concentrations are altered in RA patients.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Spektrofotometri · atomik · Selenyum

Abstract

The objective of this study was to measure the alterations in some important serum trace elements, including selenium (Se), zinc (Zn), copper (Cu), in patients with rheumatoid arthritis (RA). In the study, serum trace elements were determined by using Atomic Absorption Spectrophotometer in sera of patients with RA (n=32), and statistically compared with healthy individuals (n=52). Serum Cu concentration was found significantly higher in patients group than those of healthy individuals (26,06±4,.71 and 17,74±3,30 µmol/L, respectively) (p<0,001). In contrary, Se and Zn levels were lower in patients (0,18±0,05 µmol/L and 6,58±3,14 µmol/L, respectively) according to the healthy subjects (0,21±0,06 µmol/L and 11.44±6,00 µmol/L, respectively). Our results showed that serum trace elements (Se, Zn and Cu) concentrations are altered in RA patients. The changes may be a part of autoimmune process in organism induced by cytokines. In conclusion, we suggest that decrease in Zn and Se levels and elevation in Cu levels are probably responsive to inflammation and resulted from defence strategies of organism and mediated by the hormone-like substances.

Özet

Bu çalışmada, serum eser elementlerin önemlilerinden selenyum (Se), çinko (Zn) ve bakır (Cu), Atomik Absorbsiyon Spektrofotometre kullanılarak romatoid artritli (RA) hastaların (n=32) serumlarında belirlendi ve istatistiki olarak sağlıklı bireylerin değerleri ile (n=52) kıyaslandı. Serum Cu düzeyleri hasta grupta 26,06±4,71 µmol/L olarak bulundu ve bu değer önemli ölçüde sağlıklı bireyler grubundan yüksekti (17,74±3,30 µmol/L) (p<0,001). Buna karşın, Se ve Zn düzeyleri hastalarda (Se:0,18±0,05 µmol/L ve Zn:6,58±3,14 µmol/L) sağlıklı bireylere göre daha düşük bulundu (Se:0.21±0.06 µmol/L ve Zn:11,.44±6,00 µmol/L). Sonuçlarımız, RA'li hastalarda serumda eser elementlerinin (Se, Zn ve Cu) düzeylerinde değişim olduğunu gösterdi. Bu değişiklikler sitokinler tarafından organizmada uyarılan otoimmün sürecin bir parçası olabilir. Netice olarak, biz Zn ve Se düzeylerindeki düşme ve Cu düzeylerindeki artmanın muhtemel olarak yangıya yanıt olarak geliştiği ve organizmanın savunma stratejisinin bir sonucu olduğu ve hormon benzeri maddeler tarafından düzenlendiğini düşünmekteyiz.

Keywords

Spektrofotometri atomik Selenyum Çinko Artrit romatoid Bakır Spectrophotometry Atomic Selenium Zinc Arthritis Rheumatoid Copper

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Cite This Article

ÇOLAK, M., BİNGÖL, N. K., AYHAN, O., AVCI, Ş., BULUT, V. (2001). Romatoid artrit'de serum bakır, çinko ve selenyum düzeyleri. Romatizma Dergisi, Cilt: 16 - Sayı: 2, 66–71. https://ajindex.com/articles/307852

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