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Journals / Retina-Vitreus / 2019 / Cilt: 28 - Sayı: 3

The Role of Wide Angle Fluorescein Angiography in the Diagnosis, Follow-up and Treatment of Patients with Familial Exudative Vitreoretinopathy

Familyal Eksüdatif Vitroretinopatili Hastaların Tanı, Takip Ve Tedavisinde Geniş Açılı Fluoresein Anjiografinin Yeri

Aslı DEĞER VURAL
Bengi DEMİRAYAK
Özge Pınar AKARSU
Utku FURUNCUOĞLU
Pages
270–274
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

With sedation for children under 5 years of age, the detection of the risk of progression before development of vision-threatening complications of FEVR is possible.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of this study was to investigate the contribution of fl uorescein angiography fi ndings to the diagnosis, classifi cation, follow-up and treatment of the disease in patients with the diagnosis of familial exudative vitreoretinopathy (FEVR) that were referred to our clinic.
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Key Findings & Data:Materials and Methods: Twenty-eight eyes of 14 patients diagnosed with FEVR based on clinical findings were included in the study.
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Conclusion & Impact:With sedation for children under 5 years of age, the detection of the risk of progression before development of vision-threatening complications of FEVR is possible.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of this study was to investigate the contribution of fl uorescein angiography fi ndings to the diagnosis, classifi cation, follow-up and treatment of the disease in patients with the diagnosis of familial exudative vitreoretinopathy (FEVR) that were referred to our clinic. Materials and Methods: Twenty-eight eyes of 14 patients diagnosed with FEVR based on clinical findings were included in the study. Wideangle fl uorescein angiography (FA) was performed with the RetCam III (Imaging System Clarity Medical Systems, Pleasanton, CA, USA) in all patients under sedation and staging of the disease was performed based on angiographic findings. Results: The mean gestational age of the patients in the study was 38.57 ± 1.45 (36-40) weeks, the mean birth weight was 2745 ± 731.09 (800-4000) grams and the mean age was 47.75 ± 51.09 (3- 168) months. Eleven eyes (39.28%) had stage 1a, 2 eyes (7.14%) had stage 1b, 1 eye (3.75%) had stage 2a, 11 eyes (39.28%) had stage 2b, 1 eye (3.75%) had stage 3 FEVR and stage 5 FEVR was detected in 2 eyes (7.14%) of 2 patients. Laser photocoagulation was performed to all eyes with leakage on fl uorescein angiography. Two eyes of 2 patients had vitreoretinal surgery for stage 5 FEVR. Laser photocoagulation was applied to the fellow eyes of these patients with the diagnoses of stage3 and 1a disease. Conclusion: Wide-angle fl uorescein angiography is important in the diagnosis, treatment decision and follow-up of FEVR. With sedation for children under 5 years of age, the detection of the risk of progression before development of vision-threatening complications of FEVR is possible.

Özet

Amaç: Kliniğimize refere edilen familiyal eksüdatif vitroretinopatili (FEVR) klinik tanılı hastalarda, flöresein anjiyografi bulgularının hastalığın tanı, sınıflandırma, takip ve tedavisindeki katkılarının incelenmesi ve sonuçların bildirilmesi amaçlanmıştır. Materyal metod: Klinik bulgularına dayanılarak FEVR tanısı almış 14 hastanın 28 gözü çalışmaya dahil edildi. Tüm hastalara sedasyon altında geniş açılı flöresein anjiyografi (FA) tetkikleri RetCam III (Imaging System Clarity Medical Systems, Pleasanton, CA, USA) kullanılarak yapıldı ve evreleme anjiografi bulgularına dayanılarak gerçekleştirildi. Tüm bulgular retrospektif olarak incelendi. Bulgular: Çalışmaya dahil edilen hastaların doğum haftaları ortalama 38,57±1,45 (36-40) hafta, doğum kiloları ortalama 2745±731,09 (800-4000) gram ve ortalama yaşları 47,75 ±51,09 (3-168) ay olarak kaydedildi. Tüm gözlerin 11’inde (%39,28) evre 1a, 2’sinde (%7,14) evre 1b, 1’inde (%3,75) evre 2a, 11’inde (%39,28) evre 2b, 1’inde (%3,75) evre 3, 2’sinde (%7,14) evre 5 FEVR tespit edildi. Flöresein anjiyografi de neovaskülarizasyona bağlı sızdırma tespit edilen tüm gözlere lazer fotokoagulasyon (LFK) uygulandı. İki hastanın birer gözü evre 5 FEVR sebebiyle vitroretinal cerrahi geçirmişti. Bu hastaların diğer gözlerine tespit edilen evre3 ve 1a hastalık tanıları ile LFK uygulandı. Sonuç: Geniş açılı flöresein anjiyografi ; familiyal eksüdatif vitroretinopati hastalığının tanısının konulması, tedavi kararı ve takip sürecinde önemli bir yere sahiptir. Özellikle 5 yaş altı çocuklarda sedasyon altında uygulanması sayesinde, FEVR hastalığının görmeyi tehdit eden komplikasyonları henüz gelişmeden progresyon riskinin tespit edilmesine olanak sağladığından kıymetlidir.

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Cite This Article

VURAL, A. D., DEMİRAYAK, B., AKARSU, Ö. P., FURUNCUOĞLU, U. (2019). The Role of Wide Angle Fluorescein Angiography in the Diagnosis, Follow-up and Treatment of Patients with Familial Exudative Vitreoretinopathy. Retina-Vitreus, Cilt: 28 - Sayı: 3, 270–274. https://ajindex.com/articles/304819

References (14)

  1. Criswick VG, Schepens CL. Familial exudative vitreoretinopathy. Am J Ophthalmol. 1969;68(4):578-94.
  2. Nikopoulos K, Venselaar H, Collin RW, Riveiro-Alvarez R, Boonstra FN, Hooymans JM, Mukhopadhyay A, Shears D, van Bers M, de Wijs IJ, van Essen AJ, Sijmons RH, Tilanus MA, van Nouhuys CE, Ayuso C, Hoefsloot LH, Cremers FP. Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identifi cation of 21 novel variants in FZD4, LRP5, and NDP. Hum Mutat. 2010;31(6):656-66.
  3. Shukla D, Singh J, Sudheer G, Soman M, John RK, Ramasamy K, Perumalsamy N. Familial exudative vitreoretinopathy (FEVR). Clinical profi le and management. Indian J Ophthalmol. 2003;51(4):323-8.
  4. Canny CL, Oliver GL. Fluorescein angiographic fi ndings in familial exudative vitreoretinopathy. Arch Ophthalmol. 1976;94(7):1114-20.
  5. Pendergast SD, Trese MT. Familial exudative vitreoretinopathy. Results of surgical management. Ophthalmology. 1998;105(6):1015-23.
  6. Kashani AH, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014;121(11):2220-7.
  7. Thanos A, Todorich B, Trese MT. A Novel approach to understanding pathogenesis and treatment of capillary drpout in retinal vascular diseases. Ophthalmic Surg Lasers Imaging Retina. 2016;47:288-92.
  8. Kashani AH, Learned D, Nudleman E, Drenser KA, Capone A, Trese MT. High prevalence of peripheral retinal vascular anomalies in family members of patients with familial exudative vitreoretinopathy. Ophthalmology. 2014;121(1):262-268.
  9. Sızmaz S, Yonekawa Y, T Trese M. Familial Exudative Vitreoretinopathy. Turk J Ophthalmol. 2015;45(4):164-168.
  10. John VJ, McClintic JI, Hess DJ, Berrocal AM. Retinopathy of Prematurity Versus Familial Exudative Vitreoretinopathy: Report on Clinical and Angiographic Findings. Ophthalmic Surg Lasers Imaging Retina. 2016;47(1):14-9.
  11. Kahraman HG, Koç F, Yurdakul NS. Familial Exudative Retinopathy: A Case and Family Analysis. Turk J Ophthalmol. 2018;48:212-214.
  12. Cebeci Z, Yıldız Ekinci D, Bayraktar Ş, Kır N. Familial exudative vitreoretinopathy: Follow-up and treatment results. Turk J Ophthalmol. 2014;44:370-373.
  13. Ranchod TM, Ho LY, Drenser KA, Capone A Jr, Trese MT. Clinical presentation of familial exudative vitreoretinopathy. Ophthalmology. 2011;118:2070-5.
  14. Tauqeer Z, Yonekawa Y. Familial Exudative Vitreoretinopathy: Pathophysiology, Diagnosis, and Management. Asia Pac J Ophthalmol (Phila). 2018;7(3)