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Journals / Perinatoloji Dergisi / 2006 / Cilt: 14 - Sayı: 1

Investigation of folic acid, vitamin B12, vitamin B6 and homocysteine levels in preeclamptic

Preeklamptik gebelerde folik asit, vitamin B12, vitamin B6 ve homosistein düzeylerinin araştırılması

Ahmet KALE
Ebru KALE
Nurten AKDENİZ
Mahmut ERDEMOĞLU
Ahmet YALINKAYA
Murat YAYLA
Pages
31–36
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: High homocysteine level and low folic acid and vitamin B6 levels play a role in the pathogenesis of preeclampsia.

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the relationship between preeclampsia and serum folic acid, serum B12, plasma vitamin B6 (pyridox-.al-5'-phosphate) and plasma homocysteine levels.
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Key Findings & Data:Methods: 100 pregnant women with preeclampsia and 74 healthy pregnant women were included in the study from September 2004 to August 2005.
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Conclusion & Impact:Conclusion: High homocysteine level and low folic acid and vitamin B6 levels play a role in the pathogenesis of preeclampsia.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Vitamin B 6 · Homosistein · Vitamin B 12

Abstract

To investigate the relationship between preeclampsia and serum folic acid, serum B12, plasma vitamin B6 (pyridox-.al-5'-phosphate) and plasma homocysteine levels. Methods: 100 pregnant women with preeclampsia and 74 healthy pregnant women were included in the study from September 2004 to August 2005. Serum vitamin B12, folic acid and plasma vitamin B6 and homocysteine levels were measured in all patients at their third trimester of pregnancy. Results: Vitamin B12 serum levels in the preeclamptic and the control group were similar (117.44±42.03 pg/ml in the preeclamptic group and 136.07±59.01 pg/ml in the control group, p>0.05 ). Vitamin B6 (pyridoxal-5'-phosphate) plasma levels in preeclampsia group were lower than control group (6.40±2.91ug/l in preeclampsia group and 11.15±5.76 ug/l in the control group p<0.001). Folic acid serum levels in the preeclampsia group were lower (5.43±3.08 ng/ml in the control, 8.00±5.1 ng/ml, in the preeclamptic group, pO.001). Homocysteine plasma levels were significantly higher in the preeclampsia group than control group (10.50±6.21 umol/L in the preeclamptic group and 6.54.±2.64 umol/L in the control group, pO.001). Conclusion: High homocysteine level and low folic acid and vitamin B6 levels play a role in the pathogenesis of preeclampsia.

Özet

Amaç : Preeklampsi ile serum folik asit,serum vitamin B12,plazma vitamin B6 (piridoksal 5 fosfat) ve plazma homosistein düzeyleri arasındaki ilişkinin araştırılması. Yöntem : Eylül 2004-Ağustos 2005 tarihleri arasında,kliniğimize başvuran ve preeklampsi tanısı alan 100 gebe ile herhangi bir medikal problemi olmayan 74 sağlıklı gebe çalışmaya dahil edildi.Bütün hastalardan gebeliğin 3.trimesterinde serum vitamin B12,serum folik asit,plazma vitamin B6 ve plazma homosistein konsantrasyonları ölçüldü. Bulgular : Vitamin B12 serum düzeyleri preeklampsi ve kontrol grupları arasında benzerdi (sırası ile; 117.44±42.03 pg/ml,136.07±59.01 pg/ml,p>0.05).Vitamin B6 (piridoksal 5 fosfat) plazma düzeyi preeklampsi grubunda kontrol grubuna göre düşük bulundu (sırası ile; 6.40±2.91 µg/l,11.15±5.76 µg/l,p<0.001).Folik asit serum düzeyi preeklampsi grubunda daha düşük saptandı (sırası ile;5.43±3.08 ng/ml, 8.00±5.1 ng/ml, p<0.001).Homosistein plazma düzeyi ise preeklampsi grubunda kontrol grubuna göre anlamlı oranda yüksekti (sırası ile; 10.50±6.21 µmol/L, 6.54±2.64 µmol/L, p<0.001). Sonuç : Yüksek homosistein konsantrasyonu ile düşük folik asit ve vitamin B6 düzeyleri preeklampsinin patogenezinde rol oynayabilir.

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Cite This Article

KALE, A., KALE, E., AKDENİZ, N., ERDEMOĞLU, M., YALINKAYA, A., YAYLA, M. (2006). Investigation of folic acid, vitamin B12, vitamin B6 and homocysteine levels in preeclamptic. Perinatoloji Dergisi, Cilt: 14 - Sayı: 1, 31–36. https://ajindex.com/articles/300340

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