Journals / MN Kardiyoloji / 1997 / Cilt: 4 - Sayı: 3

Effects of L-Carnitin on stable angina pectoris

Stabil anjina pektoriste L-Carnitin'in terapötik etkisi

Pages
218–220
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Maximal ST depression, time to. initiation ofST depression of 1 mm, maximal heart rate and double product were not altered significantly.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Effects of L-Carnitin on Stable Angina Pectoris It has been shown that ischemic conditions are associated with reduction of free L-Carnitine levels in myocardial tissue and suggested that L-Carnitine may protect ischemic miyocardium by various mechanisms.
📊
Key Findings & Data:Fourteen patients were given 1 g L-Carnitine once a day orally for one month.
💡
Conclusion & Impact:Maximal ST depression, time to. initiation ofST depression of 1 mm, maximal heart rate and double product were not altered significantly.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Effects of L-Carnitin on Stable Angina Pectoris It has been shown that ischemic conditions are associated with reduction of free L-Carnitine levels in myocardial tissue and suggested that L-Carnitine may protect ischemic miyocardium by various mechanisms. In this study it was aimed to investigate the effects of L-Carnitine on ischemia parameters in patients with exercise induced stable angina pectoris. Fourteen patients were given 1 g L-Carnitine once a day orally for one month. Exercise ECG was performed before and at the end of therapy and repeated one week later without any therapy. After the treatment period of 4 weeks total exercise durationwas increased from 5.66+0.62 minutes to 6.47+0.79 (p<0.05) Maximal work-load was increased from 6.57±0.5 METS to 7.71+0.74 (p<0.05). Maximal ST depression, time to. initiation ofST depression of 1 mm, maximal heart rate and double product were not altered significantly.

Özet

Iskemik durumların miyokardiyal dokudaki serbest L-Carnitin düzeyinin düşmesi ile birlikte olduğu invitro olarak gösterilmiş ve L-Carnitin'in çeşitli mekanizmalarla iskemik miyokardı koruduğu öne sürülmüştür. Egzersiz uyafımlı stabil anjinapektorisi olan 14 hastada günde Igr oral Carnitin tedavisi 1 ay boyunca verilerek Bruce protokolü ile L-Carnitin tedavisi öncesi, 1 ay sonra ve ilaç bı¬rakıldıktan 1 hafta sonrası, egzersiz EKG incelemeleri yapılarak L-Carnitin 'in iskemi parametreleri üzerindeki etkisinin araştırılması amaçlandı. Dört haftalık L-Carnitin tedavisi ile ortalama maksimal egzersiz süresi 5.66+0.62 dk'dan 6.47±0.79 dk'ya uzadı (p<0.05). Maksimum iş yükü 6.57+0.53 METS'den 7.71±0.74 METS'e yükseldi (p<0.05). Maksumum ST depresyonu, 1 mm 'lik ST depresyonu başlangıç zamanı, makimal kalp hızı ve basınç - nabız çarpım ürününde anlamlı bir değişiklik olmadı.

🔖

Cite This Article

KORKMAZ, K., SAĞKAN, O., ÖRNEK, E., YEŞİLDAĞ, O., DURNA, K. (1997). Effects of L-Carnitin on stable angina pectoris. MN Kardiyoloji, Cilt: 4 - Sayı: 3, 218–220. https://ajindex.com/articles/298257