AI Summary & Key Takeaways
AI InsightIn suppression of intimal hyperplasia, Although no statistically significant difference was revealed between acetylsalicylate group and ticlopidin and acetylsalicylate combination groups, there was statistically significant difference between these groups and ticlopidin and control groups.
📌 3 Key Takeaways
Abstract
To investigate the effects of acetylsalicy late and ticlopidine and combination of these drugs in suppression of intimal hyperplasia, balloon injury was applied to the common carotid arteries of 24 rats. They were divided in;4 groups; acetylsalicylate, ticlopidine, both drugs together and no drug groups. Ten days later, rats were sacrified and common carotid arteries were pathologically examined. Intimal index (intimal thickness /medial thickness) was calculated. In suppression of intimal hyperplasia, Although no statistically significant difference was revealed between acetylsalicylate group and ticlopidin and acetylsalicylate combination groups, there was statistically significant difference between these groups and ticlopidin and control groups.
Özet
Asetilsalisilik asit ve tiklopidinin ayrı ayrı veya kombine olarak kullanımında intimai hiperplazinin baskılanmasına olan etkilerini araştırmak amacıyla ana karotis arterlerine balon hasarı uygulanan 24 adet sıçan 4 guruba ayrıldı. Birinci guruptaki sıçanlara asetilsalisilik asit 2. guruptakilere tiklopidin HCL, 3. guruptakilere her iki ilaç birlikte verildi, 4. guruptakilere herhangi bir ilaç verilmedi. 10 gün sonra sakrifiye edilen sıçanların karotis arterleri çıkartılarak patolojik incelemeye alındı, intimai indeks (intimalmedia kalınlık oranı) hesaplandı, intimai hiperplazinin baskilanmasmda asetilsalisilik asit ve asetilsalisilik asit ile tiklopidin birlikte kullanıldığı guruplar arasında anlamlı farklılık bulunmazken, bu guruplar ile tiklopidin ve kontrol gurupları arasında anlamlı farklılık tespit edildi.