SavedAdd your journal

Journals / MN Kardiyoloji / 2018 / Cilt: 25 - Sayı: 4

A Potential Marker of Mitral Annular Calcification: Monocyte Count - to- High Density Lipoprotein Cholesterol Ratio

Mitral Anulus Kalsifikasyonu İçin Potansiyel Bir Belirteç: Monosit Sayısı / Yüksek Yoğunluklu Lipoprotein Kolesterol Oranı

MEVLÜT SERDAR KUYUMCU
Aliye KUYUMCU
ÇAĞRI YAYLA
Mustafa Bilal ÖZBAY
Muhammed SÜLEYMANOĞLU
SİNAN AYDOĞDU
Pages
160–165
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Higher monocyte count-to-high-density lipoprotein-cholesterol ratio which indicates an enhanced inflammation and ox- idative stress was significantly and independently associated with mitral annular calcification.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To determine the association of monocyte count-to-high-density lipoprotein-cholesterol ratio (MHR), a recently emerged in- flammatory marker, with mitral annular calcification.
📊
Key Findings & Data:Material and Method: A total of 1158 patients with mitral annular calcification and 540 patients without mitral annular calcification enrolled into the study.
💡
Conclusion & Impact:Conclusions: Higher monocyte count-to-high-density lipoprotein-cholesterol ratio which indicates an enhanced inflammation and ox- idative stress was significantly and independently associated with mitral annular calcification.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To determine the association of monocyte count-to-high-density lipoprotein-cholesterol ratio (MHR), a recently emerged in- flammatory marker, with mitral annular calcification. Material and Method: A total of 1158 patients with mitral annular calcification and 540 patients without mitral annular calcification enrolled into the study. Monocyte count-to-high-density lipoprotein-cholesterol ratio and all data were compared between patients with and without mitral annular calcification. We also performed univariate and multivariate analysis to possible risk factors Results: Monocyte count-to-high-density lipoprotein-cholesterol ratio was significantly higher in patients with mitral annular calcifica- tion than control group (p <0.001). Monocyte count-to-high-density lipoprotein-cholesterol ratio (OR: 0.915, 95% CI: 0.310 - 1.520, p <0.001), mean platelet volume (OR: 0.614, 95% CI: 0.546 - 0.690, p<0.001), neutrophil to-lymphocyte ratio (OR: 0.474, 95% CI: 0.322 - 0.698, p=0.026) and monocyte (OR: 0.032, 95% CI: 0.002 - 0.124, p=0.023) levels were found to be significantly and independently as- sociated with the presence of mitral annular calcification. Conclusions: Higher monocyte count-to-high-density lipoprotein-cholesterol ratio which indicates an enhanced inflammation and ox- idative stress was significantly and independently associated with mitral annular calcification.

Özet

Amaç: Yeni tanımlanmış bir enflamasyon belirteci olan monosit sayısı - yüksek yoğunluklu lipoprotein oranı ile mitral anulus kalsifikas- yonu arasındaki ilişkiyi tanımlamak. Gereç ve Yöntemler: Toplam mitral anulus kalsifikasyonu saptanmış 1.158 hasta ve mitral anulus kalsifikasyonu saptanmayan 540 has- ta çalışmaya dahil edildi. Toplanılan tüm veriler ve mitral anulus kalsifikasyonu, mitral anulus kalsifikasyonu saptanan ve mitral anulus kalsifikasyonu saptanmayan hasta gurpları arasında karşılaştırıldı. Ayrıca tek değişkenli ve çok değişkenli regresyon analizi olası risk fak- törleri için uygulandı. Bulgular: Monosit sayısı - yüksek yoğunluklu lipoprotein oranı, mitral anulus kalsifikasyonu saptanan hasta grubunda kontrol grubuna göre anlamlı olarak yüksek saptandı (p <0,001). Monosit sayısı - yüksek yoğunluklu lipoprotein oranı (OR: 0,915, %95 CI: 0,310 - 1.520, p <0,001), ortalama trombosit hacmi (OR: 0,614, %95 CI: 0,546 - 0,690, p<0,001), nötrofil lenfosit oranı (OR: 0,474, %95 CI: 0,322 - 0,698, p=0,026) ve monosit sayısı (OR: 0,032, %95 CI: 0,002 - 0,124, p=0,023) düzeyleri mitral anulus kalsifikasyonun bulunması açısından ista- tiksel olarak anlamlı ve güçlü, bağımsız risk faktörleri olarak saptandı. Sonuç: Artmış inflamasyon ve oksidatif stresin belirteci olan monosit sayısı - yüksek yoğunluklu lipoprotein oranı, Güçlü ve bağımsız bir şekilde mitral anulus kalsifikasyonu ile ilişkilidir.

🔖

Cite This Article

KUYUMCU, M. S., KUYUMCU, A., YAYLA, Ç., ÖZBAY, M. B., SÜLEYMANOĞLU, M., AYDOĞDU, S. (2018). A Potential Marker of Mitral Annular Calcification: Monocyte Count - to- High Density Lipoprotein Cholesterol Ratio. MN Kardiyoloji, Cilt: 25 - Sayı: 4, 160–165. https://ajindex.com/articles/297872

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Adler Y, Herz I, Vaturi M, et al. Mitral annular calcium de- tected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 1998;82:1183-6.
  2. Adler Y, Koren A, Fink N, et al. Association between mitral annulus calcification and caro tid atherosclerotic disease. Stroke 1998;29:1833-7.
  3. Fox CS, Vasan RS, Parise H, et al. Mitral Annular Calci - fication Predicts Cardio vas cular Morbidity and Mortality. Circulation 2003;107:1492. Allison MA, Cheung P, Criqui MH, Langer RD, Wright CM. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006; 113:861-6.
  4. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in per- sons older than 62 years in a long-term health care facility. Am J Cardiol 1987;59:381-2.
  5. Afshar M, Luk K, Do R, Dufresne L, Owens DS, Harris TB, et al. Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol 2017; 69:2941-8.
  6. Navab M, Reddy ST, Van Lenten BJ, Fogelman AM. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nat Rev Cardiol 2011;8:222-32. Biswas SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev 2016;2016:5698931. Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 2014;46:1619-25.
  7. Canpolat U, Cetin EH, Cetin S, et al. Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflam ma tion. Clin Appl Thromb Hemost 2016;22:476-82.
  8. Cetin EH, Cetin MS, Canpolat U, et al. Monocyte/HDL-cho- lesterol ratio predicts the definite stent thrombosis after primary percutaneous coronary intervention for ST-seg- ment elevation myocardial infarction. Biomark Med 2015;9:967-77.
  9. Yayla KG, Canpolat U, Yayla Ç, et al. A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio. Acta Cardiologica Sinica 2017;33:41-9.
  10. Potpara TS, Vasiljevic ZM, Vujisic-Tesic BD, et al. Mitral an-nular calcification predicts cardiovascular morbidity and mortality in middle-aged patients