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Journals / MN Kardiyoloji / 2002 / Cilt: 9 - Sayı: 6

Comparison of cell adhesion molecule levels in coronary artery disease and syndrome X

Koroner arter hastalığında ve sendrom X'de hücre adezyon molekül düzeylerinin karşılaştırılması

Bektaş BATTALOĞLU
Feridun KOŞAR
Nevzat ERDİL
Vedat NİSANOĞLU
Barış OTLU
Nurzan SEZGİN
Elif ÖZEROL
Rıza DURMAZ
Sengül ÇEHRELİ
Pages
403–406
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: These results suggest that ICAM and VCAM may play an important role in the pathogenesis of coranary artey disease than in the pathogenesis of syndrome X.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: It has previously been shown that cell adhesion molecules are involved in the pathogenesis of atherosclerosis and coronary artery disease.
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Key Findings & Data:We examined the clinical significance of cell adhesion molecules; intracell adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin in the diagnosis of coronary artery disease (CAD) and syndrome X (S-X) and the relation between the levels of these molecules and these diseases.
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Conclusion & Impact:CONCLUSION: These results suggest that ICAM and VCAM may play an important role in the pathogenesis of coranary artey disease than in the pathogenesis of syndrome X.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Koroner arteriyoskleroz · E-selektin · Vasküler hücre adezyon molekülü-1

Abstract

AIM: It has previously been shown that cell adhesion molecules are involved in the pathogenesis of atherosclerosis and coronary artery disease. However, only few studies have addressed the relation between these molecules and syndrome X. We examined the clinical significance of cell adhesion molecules; intracell adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin in the diagnosis of coronary artery disease (CAD) and syndrome X (S-X) and the relation between the levels of these molecules and these diseases. MATERIAL AND METHODS: The study included 25 patients with coronary artery disease (15 men,10 women; mean age:57±7 years) and 25 patients with syndrome X (8 men, 17 women; mean age:55±5 years) and 30 the control subjects (CS ). RESULTS: The levels of studied cell adhesion molecules in the CAD patients were greater than CS. The levels of ICAM-1 and VCAM-1 in CAD group were greater than in S-X group (49.12±12.01 vs 42.34±11.12, P<0.001 and 35.62±15.13 vs 26.42±11.30, P<0.001 respectively).There was no significant difference between S-X group and with respect to cell adhesion molecules. However, S-X patients showed a tendency to increase the levels of all cell adhesion molecules. CONCLUSION: These results suggest that ICAM and VCAM may play an important role in the pathogenesis of coranary artey disease than in the pathogenesis of syndrome X.

Özet

AMAÇ: Hücre adezyon moleküllerinin ateroskleroz veya koroner arter hastalığının patogenezinde rol oynadıkları daha önceden gösterilmiştir. Fakat sadece birkaç çalışmada bu moleküller ile sendrom X arasındaki ilişkiye değinilmiştir. Biz ateroskleroz veya koroner arter hastalığı ve sendrom X teşhisinde hücre adezyon moleküllerinin; ICAM, VCAM, E-selectin saptanmasının klinik önemini ve bu molekül düzeyleri ile sözü edilen hastalıklar arasındaki ilişkiyi araştırdık. GEREÇ VE YÖNTEM: Bu çalışma 25 koroner arter hastası (15 erkek,10 kadın; ortalama yaş:57±7 yıl) ve 25 sendrom X hastası (8 erkek, 17 kadın; ortalama yaş:55±5 yıl) ve 30 kontrol olgusunu içeriyordu. BULGULAR: Koroner arter hastalığı grubunda kontrol grubuna göre çalışılan adezyon molekül düzeyleri yüksekti. Koroner arter hastalığı grubunda sendrom X grubuna göre interselüler adezyon molekülü (ICAM-1) ve vascüler hücre adezyon molekülü (VCAM-1) düzeyleri daha yüksek idi (Sırasıyla 49.12±12.01 karşın 42.34±11.12, P<0.001 ve 35.62±15.13 karşın 26.42±11.30, P<0.001). Tüm adezyon moleküllerinde sendrom X ve kontrol grubu arasında önemli bir fark yoktu. Sendrom X hastaları tüm adezyon molekül düzeylerinde artmaya bir eğilim gösterdi. SONUÇ: Bu sonuçlar tüm adezyon moleküllerinin sendrom X patogenezinden daha çok, koroner arter hastalığı patogenezinde önemli bir rol oynayabileceğini göstermektedir.

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Cite This Article

BATTALOĞLU, B., KOŞAR, F., ERDİL, N., NİSANOĞLU, V., OTLU, B., SEZGİN, N., ÖZEROL, E., DURMAZ, R., ÇEHRELİ, S. (2002). Comparison of cell adhesion molecule levels in coronary artery disease and syndrome X. MN Kardiyoloji, Cilt: 9 - Sayı: 6, 403–406. https://ajindex.com/articles/297715

References (14)

  1. Munro JM, Cotran RS. The pathogenesis of atherosclerosis; Atherogenesis and inflammation. Lab Invest 1998; 58:249-54.
  2. Munro JM, Van der Walt JD, Munro CS, Chulmers JAC, Cox El. An immunohistochemical analysis of human aortic fatty streaks. Hum Pathol 1987; 18:375-81.
  3. Janasson L, Helm D, Skalli O, Bandjers G, Hansson GK. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plague. Arteriosclerosis 1986; 6:131-7.
  4. Joris I, Zand T, Nunnari JJ, Krolikowski FJ, Majna G. Studies on the pathogenesis of atherosclerosis:Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am J Pathol 1983; 113:341-7. Gerrity RG. The role of the monpcyte in atherogenesis; Transition of blood-borne monocytes into foam cells in flatty lesions. Am J pathol 1973;103:181-9.
  5. Saku K, Zhang B.Ohta T, Shirai K, Tsuchİya Y, Arakawa K. Levels of soluble cell adhesion moleculs in patients with angiographically defined coronary atherosclerosis. Jpn-Circ J 1999; 63:19-24.
  6. Davies MJ, Gordon J.L, Gearing AJH, et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Patho 1993; 171:223-9.
  7. Hwang SJ, Ballantyne CM, Sharrett AR, et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases. Circulation. 1997; 96:4219-25.
  8. O'Brien KD, McDonald TO, Chait A, Allen MD, Alpers CE. Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leucocyte content. Circulation 1996; 93:672-82.
  9. Caterina RD, Basta G, Lazzerini G, et al. Soluble vascular cell adhesion molecule-1 as a biohumoral correlate of atherosclerosis. Atherioscler Thromb Vase Biol 1997; 17:2646-54.
  10. Cybulsky Ml, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991; 251:788-91.
  11. Blann AD, McCollum CN. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb Haemostasis 1994; 72:151-4.
  12. Rothleine R, Mainolfi EA, Czajkowski M, Marlin SD. A form of circulating ICAM-1 in human serum. J Immunol 1991; 147:3788-93.
  13. Pigott R, Dillon LP, Hemigway I, Gearing AJH. Soluble forms of E- selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultered endothelial cell. Biochem Biophys Res Commun 1992; 187:584-9.
  14. Nakai K, Itoh C, Ka