Journals / MN Kardiyoloji / 2002 / Cilt: 9 - Sayı: 2

Evaluation of arterial distensibility in patients with microalbuminuric non-insulin dependent diabetes mellitus

İnsülin bağımlı olmayan mikroalbuminürik diyabetes mellituslu hastalarda arteriyel distansibilitenin değerlendirilmesi

Pages
132–136
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: The arterial distensibility may give important clues about the changes of structure and function in the vascular system in diabetics with microalbuminuria.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:AIM: This study was undertaken to detect the relationship of microalbuminuria (which is one of the indicators of the diabetic regulation) with the arterial distensibility in non-insulin dependent diabetes mellitus (NIDDM) patients.
📊
Key Findings & Data:MATERIAL AND METHOD: Thirtyfive (25 women,10 men) NIDDM patients (mean age 61.4±9.4 years, ranging between 45-77) and 20 subjects (13 women, 7 men, mean age 58.6±15.5 years, ranging between 40-73) as the control group were enrolled to the study.
💡
Conclusion & Impact:CONCLUSION: The arterial distensibility may give important clues about the changes of structure and function in the vascular system in diabetics with microalbuminuria.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kan basıncı · Koroner arteriyoskleroz · Diabetes mellitus

Abstract

AIM: This study was undertaken to detect the relationship of microalbuminuria (which is one of the indicators of the diabetic regulation) with the arterial distensibility in non-insulin dependent diabetes mellitus (NIDDM) patients. MATERIAL AND METHOD: Thirtyfive (25 women,10 men) NIDDM patients (mean age 61.4±9.4 years, ranging between 45-77) and 20 subjects (13 women, 7 men, mean age 58.6±15.5 years, ranging between 40-73) as the control group were enrolled to the study. Arterial distensibility was evaluated from the (aortic) carotid- femoral arteries by the Complior system. RESULTS: The mean ages of the two groups were not statistically different (p=0.4). Systolic and diastolic blood pressures, pulse wave velocity, body mass index, glucose, HbA1c, cholestrole and microalbuminuria levels were statistically significantly higher in the NIDDM patients (p<0.0001, p<0.004, p<0.0001, p<0.0004, p<0.0001, p<0.0001, p<0.0001, p<0.03, p<0.0001 respectively). There was a significant correlation between the pulse wave velocity and age (p=0.02), body mass index (p=0.04), systolic blood pressure (p=0.01), microalbuminuria (p=0.03) and the duration of diabetes (p<0.05). CONCLUSION: The arterial distensibility may give important clues about the changes of structure and function in the vascular system in diabetics with microalbuminuria.

Özet

AMAÇ: Bu çalışmada insülin bağımlı olmayan diyabetes mellituslu hastalarda, koroner arter hastalığına ait önemli bir risk faktörü olduğu ifade edilen mikroalbuminüri ile arteriyel distansibilite arasındaki ilişki incelenmek istenmiştir. GEREÇ VE YÖNTEM: Çalışmaya yaşları 45-77 (ortalama 61.4±9.4 yıl) arasında değişen toplam 35 (25 kadın, 10 erkek) insülin bağımlı olmayan diyabetes mellitus hastası ile yaşları 40-73 (ortalama 58.6±15.5 yıl) arasında değişen 20 (13 kadın, 7 erkek) kontrol grubu alındı. Arteriyel distansibilite (aortik) karotis-femoral arterler kullanılarak Complior cihazı ile değerlendirildi. BULGULAR: Yaş açısından iki grup arasında istatistiksel olarak anlamlı bir farklılık yoktu (p=0.4). Sistolik ve diyastolik kan basınçları, nabız dalga hızı, vücut-kitle indeksi, glukoz, HbA1c, kolesterol ve mikroalbuminüri değerleri diyabetli hastalarda anlamlı olarak yüksekti (sırası ile p<0.0001, p=0.004, p<0.0001, p=0.0004, p<0.0001, p<0.0001, p=0.03, p<0.0001). Yaş (p=0.02), vücut-kitle indeksi (p=0.04), sistolik kan basıncı (p=0.01), mikroalbuminüri (p=0.03) ve diyabet süresi (p<0.05) ile nabız dalga hızı arasında anlamlı bir ilişki mevcuttu. SONUÇ: Sonuç olarak; mikroalbuminüri varlığında arteriyel distansibilite diyabetik hastalarda damar duvarındaki yapısal ve fonksiyonel değişiklikler hakkında önemli bilgiler verebilir.

🔖

Cite This Article

YILDIZ, M., İNNİCE, M., GÜL, Ç., TATLI, E., DURAKOĞLU, Z. (2002). Evaluation of arterial distensibility in patients with microalbuminuric non-insulin dependent diabetes mellitus. MN Kardiyoloji, Cilt: 9 - Sayı: 2, 132–136. https://ajindex.com/articles/297680

References (8)

  1. Reaven GM, Litheli H, Landsberg L. Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. NEJM 1996; 334:1173. Dunn FL. Management of hyperlipidemia in diabetes mellitus. Endokrinol Metab Clin North Am 1992; 21:395. Garber AJ, Ninik Al, Crespin SR. Dedection and management of lipid disorders in diabetic patients: A commentary for clinicians. Diabetes Care 1991; 15:1.0.68. Borch-Johnsen K, Feldt-Rasmussen B, Strandgaard S, et al. Urinary albumin excretion: an independent predictor of ischemic heart diseases. Arterioscler Thromb Vase Biol 1999;. 19:1992-7.
  2. Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non-insulin dependent diabetes mellitus. Arch Intern Med 1997; 157:1413-8.
  3. Clausen P, Jensen JS, Borch-Johnsen K, et al. Ambulatory blood pressure and urinary albumin excretion in clinically healthy subjects. Hypertension 1998; 32:71-7.
  4. Jensen JS, Borch-Johnsen K, Deckert T, et al. Reduced glomerular size and charge-selectivity in clinically healthy individuals with microalbuminuria. Eur J Clin Invest 1995; 25:608-14.
  5. Jensen JS, Borch-Johnsen K, Jensen G, et al. Microalbuminuria reflects a generalized transvascular albumin leakiness in clinically healthy subjects. Clin Sci 1995; 88:629-33. Jensen T. Increased plasma concentration of von Willebrand Factor in insulin dependent diabetics with incipient nephropathy. BMJ 1989; 298:27-8. Asmar R. Arterial Stifness and Pulse Wave Velocity (clinical applications): Elsevier SAS 1999: 93. Tuncel E, Imamoğlu Ş. Metabolik Sendrom (Sendrom X). Galenos 1997; 1:21-5.
  6. Wahlquvist ML, Relf IR, Myers KA, Lo CS. Diabetes and macrovascular disease: risk factors for atherogenesis and non- invasive investigation of arterial disease. Hum Nutr Clin Nutr 1984; 38:175-84.
  7. Lehmann ED, Gosling RG, Sönksen PH et al. Arterial wall compliance in diabetes. Diabet Med 1992; 9:114- 9. Asmar R, Topouchian J, Pannier B, Rudnichi A, Safar M. Reversion of arterial abnormalities by long-term antihypertensive therapy in a large population. The Complior study. J Hypertens 1999; 17: Suppl 3:S9. Toto-Moukouo JJ, Achimastos A, Asmar R, Hughes CJ, Safar ME. Pulse wave velocity in patients with obesity and hypertension. Am Heart J 1986; 112:136-40.
  8. Pujla A, Gnasso A et al. Common carotid arterial wall thickness in NIDDM subjects. Diabetes Care 1994; 17:1330. Tanokuchi S, Okada S, Ota Z, et al. Factors related to aortic pulse wave velocity in patients with non-insuli