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Journals / Molecular Imaging and Radionuclide Therapy / 2018 / Cilt: 27 - Sayı: 3

Primeri Bilinmeyen Kanserlerde 18F-FDG PET/BT’nin Tanısal Değeri

Diagnostic Value of 18F-FDG PET/CT in Patients with Carcinoma of Unknown Primary

ARZU CENGİZ
Sibel GÖKSEL
YAKUP YÜREKLİ
Pages
126–132
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Primer tümör saptanması yanında hastalığın yaygınlığını da belirleyerek hastaların izlemine katkıda bulunur.

📌 3 Key Takeaways

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Objective & Hypothesis:Amaç: Bu çalışmanın amacı, primeri bilinmeyen kanserlerde (PBK) 18F-florodeoksiglukoz (18F-FDG) pozitron emisyon tomografi/ bilgisayarlı tomografinin (PET/BT) klinik rolünü araştırmaktır.
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Key Findings & Data:Yöntem: Bu retrospektif çalışmaya PBK tanısıyla tüm vücut 18F-FDG PET/BT yapılan 121 hasta dahil edildi.
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Conclusion & Impact:Primer tümör saptanması yanında hastalığın yaygınlığını da belirleyerek hastaların izlemine katkıda bulunur.
🔬Design:Research Article
📍Scope:121 hasta
⚙️Variables:Domain Parameters

Abstract

Amaç: Bu çalışmanın amacı, primeri bilinmeyen kanserlerde (PBK) 18F-florodeoksiglukoz (18F-FDG) pozitron emisyon tomografi/ bilgisayarlı tomografinin (PET/BT) klinik rolünü araştırmaktır. Yöntem: Bu retrospektif çalışmaya PBK tanısıyla tüm vücut 18F-FDG PET/BT yapılan 121 hasta dahil edildi. Sonuç tanı histopatolojik olarak veya klinik izlemle doğrulandı. Bulgular: 18F-FDG PET/BT, 121 hastanın 59’unda (49%) primer tümörü saptadı. PET/BT ile en çok saptanan tümör akciğer kanseri idi (n=31). Bir hastada iki primer tümör saptandı (kolon ve prostat). Bu hastada kemik iliği biyopsisi prostat kanseri metastazını gösterdiği için kolon kanseri senkron ikinci primer olarak kabul edildi. 18F-FDG PET/BT bulguları 11 hastada yanlış pozitif idi. PET/BT ile herhangi bir lezyon saptanmayan 51 hastanın 11 tanesinde konvansiyonel tetkiklerle primer tümör saptandı ve bu hastalar yanlış negatif olarak değerlendirildi. Primer tümör saptanmasında 18F-FDG PET/BT ile duyarlılık, özgüllük ve doğruluk sırasıyla %84, %78 ve %82 idi.Sonuç: PBK olan hastalarda primer tümörün saptanmasında tüm vücut 18F-FDG PET/BT etkin bir yöntemdir. Primer tümör saptanması yanında hastalığın yaygınlığını da belirleyerek hastaların izlemine katkıda bulunur.

Özet

Objective: The aim of this study is to investigate the clinical role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP). Methods: One hundred twenty one patients with a diagnosis of CUP who underwent whole body 18F-FDG PET/CT imaging were included in this retrospective study. The final diagnoses were confirmed either histopathologically or by clinical follow-up. Results: The 18F-FDG-PET/CT successfully detected the primary tumor in 59 out of 121 (49%) patients. The most common primary tumor as detected by 18F-FDG PET/CT was lung cancer (n=31). In a patient, two primary tumors (colon and prostate) were detected on PET/CT imaging. Bone marrow biopsy revealed prostate cancer in this patient and the colon cancer was accepted as a synchronous second primary tumor. 18F-FDG PET/CT findings were false-positive in 11 patients. 18F-FDG PET/ CT could not detect any primary lesion in 51 patients, whose conventional work-up detected a primary tumor in 11 and thus considered as false-negative. The sensitivity, specificity rate and accuracy of 18F-FDG PET/CT in detection of primary tumor were identified as 84%, 78% and 82%, respectively. Conclusion: Whole body 18F-FDG PET/CT is an effective method for detecting the primary tumor in patients with CUP. In addition to detecting the primary tumor, it can also help determine disease extent and contribute to patient management.

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Cite This Article

CENGİZ, A., GÖKSEL, S., YÜREKLİ, Y. (2018). Primeri Bilinmeyen Kanserlerde 18F-FDG PET/BT’nin Tanısal Değeri. Molecular Imaging and Radionuclide Therapy, Cilt: 27 - Sayı: 3, 126–132. https://ajindex.com/articles/295117

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References (12)

  1. Pavlidis N, Fizazi K. Carcinoma of unknown primary (CUP). Crit Rev Oncol Hematol 2009;69:271-278.
  2. Kwee TC, Basu S, Cheng G, Alavi A. FDG PET/CT in carcinoma of unknown primary. Eur J Nucl Med Mol Imaging 2010;37:635-644.
  3. Pavlidis N, Briasoulis E, Hainsworth J, Greco FA. Diagnostic and therapeutic management of cancer of unknown primary. Eur J Cancer 2003;39:1990-2005.
  4. Chorost MI, Lee MC, Yeoh CB, Molina M, Ghosh BC. Unknown primary. J Surg Oncol 2004;15;87:191-203.
  5. Haas I, Hoffmann TK, Engers R, Ganzer U. Diagnostic strategies in cervical carcinoma of an unknown primary (CUP). Eur Arch Otorhinolaryngol 2002;259:325-333.
  6. Raber MN, Faintuch J, Abbruzzese JL, Sumrall C, Frost P. Continuous infusion 5-fluorouracil, etoposide and cisdiamminedichloroplatinum in patients with metastatic carcinoma of unknown primary origin. Ann Oncol 1991;2:519-520.
  7. Pentheroudakis G, Briasoulis E, Pavlidis N. Cancer of unknown primary site: missing primary or missing biology? Oncologist 2007;12:418425. van de Wouw AJ, Jansen RL, Speel EJ, Hillen HF. The unknown biology of the unknown primary tumour: a literature review. Ann Oncol 2003;14:191-196. Sève P, Billotey C, Broussolle C, Dumontet C, Mackey JR. The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site. Cancer 2007;109:292-299. 10. Rusthoven KE, Koshy M, Paulino AC. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. Cancer 2004;101:2641-2649.
  8. Delgado-Bolton RC, Fernández-Pérez C, González-Maté A, Carreras JL. Meta analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors. J Nucl Med 2003;44:1301-1314.
  9. Gutzeit A, Antoch G, Kühl H, Egelhof T, Fischer M, Hauth E, Goehde S, Bockisch A, Debatin J, Freudenberg L. Unknown primary tumors: detection with dual-modality PET/CT--initial experience. Radiology 2005;234:227-234.
  10. Roh JL, Kim JS, Lee JH, Cho KJ, Choi SH, Nam SY, Kim SY. Utility of combined (18)F-fluorodeoxyglucose-positron emission tomography and computed tomography in patients with cervical metastases from unknown primary tumors. Oral Oncol 2009;45:218-224.
  11. Lonneux M, Reffad A. Metastases from Unknown Primary Tumor. PET-FDG as Initial Diagnostic Procedure? Clin Positron Imaging. 2000;3:137-141.
  12. Rusthoven KE, Koshy M, Paulino AC. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown p