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Dergiler / Molecular Imaging and Radionuclide Therapy / 2018 / Cilt: 27 - Sayı: 3

Diagnostic Value of 18F-FDG PET/CT in Patients with Carcinoma of Unknown Primary

Primeri Bilinmeyen Kanserlerde 18F-FDG PET/BT’nin Tanısal Değeri

ARZU CENGİZ
Sibel GÖKSEL
YAKUP YÜREKLİ
Sayfa
126–132
DOI
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In addition to detecting the primary tumor, it can also help determine disease extent and contribute to patient management.

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Amaç & Hipotez:Objective: The aim of this study is to investigate the clinical role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP).
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Temel Bulgular & Veri:Methods: One hundred twenty one patients with a diagnosis of CUP who underwent whole body 18F-FDG PET/CT imaging were included in this retrospective study.
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Sonuç & Katkı:In addition to detecting the primary tumor, it can also help determine disease extent and contribute to patient management.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The aim of this study is to investigate the clinical role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP). Methods: One hundred twenty one patients with a diagnosis of CUP who underwent whole body 18F-FDG PET/CT imaging were included in this retrospective study. The final diagnoses were confirmed either histopathologically or by clinical follow-up. Results: The 18F-FDG-PET/CT successfully detected the primary tumor in 59 out of 121 (49%) patients. The most common primary tumor as detected by 18F-FDG PET/CT was lung cancer (n=31). In a patient, two primary tumors (colon and prostate) were detected on PET/CT imaging. Bone marrow biopsy revealed prostate cancer in this patient and the colon cancer was accepted as a synchronous second primary tumor. 18F-FDG PET/CT findings were false-positive in 11 patients. 18F-FDG PET/ CT could not detect any primary lesion in 51 patients, whose conventional work-up detected a primary tumor in 11 and thus considered as false-negative. The sensitivity, specificity rate and accuracy of 18F-FDG PET/CT in detection of primary tumor were identified as 84%, 78% and 82%, respectively. Conclusion: Whole body 18F-FDG PET/CT is an effective method for detecting the primary tumor in patients with CUP. In addition to detecting the primary tumor, it can also help determine disease extent and contribute to patient management.

Abstract

Amaç: Bu çalışmanın amacı, primeri bilinmeyen kanserlerde (PBK) 18F-florodeoksiglukoz (18F-FDG) pozitron emisyon tomografi/ bilgisayarlı tomografinin (PET/BT) klinik rolünü araştırmaktır. Yöntem: Bu retrospektif çalışmaya PBK tanısıyla tüm vücut 18F-FDG PET/BT yapılan 121 hasta dahil edildi. Sonuç tanı histopatolojik olarak veya klinik izlemle doğrulandı. Bulgular: 18F-FDG PET/BT, 121 hastanın 59’unda (49%) primer tümörü saptadı. PET/BT ile en çok saptanan tümör akciğer kanseri idi (n=31). Bir hastada iki primer tümör saptandı (kolon ve prostat). Bu hastada kemik iliği biyopsisi prostat kanseri metastazını gösterdiği için kolon kanseri senkron ikinci primer olarak kabul edildi. 18F-FDG PET/BT bulguları 11 hastada yanlış pozitif idi. PET/BT ile herhangi bir lezyon saptanmayan 51 hastanın 11 tanesinde konvansiyonel tetkiklerle primer tümör saptandı ve bu hastalar yanlış negatif olarak değerlendirildi. Primer tümör saptanmasında 18F-FDG PET/BT ile duyarlılık, özgüllük ve doğruluk sırasıyla %84, %78 ve %82 idi.Sonuç: PBK olan hastalarda primer tümörün saptanmasında tüm vücut 18F-FDG PET/BT etkin bir yöntemdir. Primer tümör saptanması yanında hastalığın yaygınlığını da belirleyerek hastaların izlemine katkıda bulunur.

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Bu Makaleye Atıf Yap

CENGİZ, A., GÖKSEL, S., YÜREKLİ, Y. (2018). Diagnostic Value of 18F-FDG PET/CT in Patients with Carcinoma of Unknown Primary. Molecular Imaging and Radionuclide Therapy, Cilt: 27 - Sayı: 3, 126–132. https://ajindex.com/articles/295117

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