AI Summary & Key Takeaways
AI InsightConclusion: High dose intravenous enoxaparin in combination with fibrinolytic treatment on patients with acute ST segment elevation myocardial infarction as the initial antitrombotic dose was found to be safe.
📌 3 Key Takeaways
Abstract
Aim: In this study, our aim is to investigate the safety of high dose intravenous enoxaparin in combination with fibrinolytic treatment on patients with acute ST segment elevation myocardial infarction. Material and Method: 33 patient who admitted to our hospital with the ST segment elevation myocardial infarction and undergone to fibrinolytic treatment were included in the study. All the patients were administered high dose intravenous enoxaparin as the intial antitrombotic dose. We evaluated the degree of ST segment resolution after the fibrinolytic treatment and determined the TIMI flow at the coronary angiography. The bleeding complications were also evaluated. Results: The ST segment resolution after the fibrinolytic treatment was 81.8%. At coronary angiography we detected TIMI 3 flow in 20 patients (60.6%), TIMI 2 flow in 9 patients (27.2%), TIMI 1 flow in 2 patients (6.1%) and TIMI 0 flow in 2 patients (6.1%). Web did not observe major hemorhage in any patients according to TIMI criteria but; minor hemorhage ratio was 12.1%. Conclusion: High dose intravenous enoxaparin in combination with fibrinolytic treatment on patients with acute ST segment elevation myocardial infarction as the initial antitrombotic dose was found to be safe.
Özet
Amaç: ST segment elevasyonu miyokard infarktüsünde fibrinolitik tedaviye ek olarak yüksek doz intravenöz enoksaparin verilmesinin güvenirliğini saptamak. Gereç ve Yöntem: 1 Haziran 2002-1 Nisan 2003 tarihleri arasında kliniğimize ST segment elevasyonlu miyokard infarktüsü ile başvuran ve fibrinolitik tedavi alan hastalardan başlangıç dozu olarak yüksek doz intravenöz enoksaparin uygulanan 33 hasta çalışmaya dahil edildi. Bu hastalarda fibrinolitik sonrası ST segment rezolüsyonu ve koroner anjiografide infarktan sorumlu arterin TIMI sınıflandırmasına göre açıklık oranı belirlendi ve kanama komplikasyonu değerlendirildi. Bulgular: Fibrinolitik sonrası ST segment rezolüsyonu oranı %81.8 bulundu. Koroner anjiografi yapılan 33 hastadan 20'sinde TIMI 3 akım (%60.6), 9'unda TIMI 2 akım (%27.2), 2'sinde TIMI 1 akım (%6.1)ve 2'sinde de TIMI 0 akım (%6.1) izlendi. Hiç bir hastada TIMI kriterlerine göre majör kanama izlenmezken, minör kanama oranı % 12.1 olarak saptandı. Sonuç: ST segment elevasyonlu miyokard infarktüsü tanısı ile fibrinolitik tedavi uygulanan hastalara, yükleme dozu olarak yüksek doz intravenöz enoksaparin uygulamak güvenlidir.