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Journals / Türk Kardiyoloji Derneği Arşivi / 2011 / Cilt: 39 - Sayı: 4

The relation of serum monocyte chemoattractant protein-1 level with coronary atherosclerotic burden and collateral degree in stable coronary artery disease

Serum monosit kemoatraktan protein-1 düzeyinin kararlı koroner arter hastalığında koroner aterosklerotik yük ve kolateral derecesi ile ilişkisi

Timur TİMURKAYNAK
Neslihan BUKAN
Salih TOPAL
Uğur ERÇİN
Asife ŞAHİNARSLAN
Sinan Altan KOCAMAN
Pages
269–275
Publication Date
2022-11-05
DOI
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The patients were divided into four groups: those with normal coronary arteries (NCA); those with coronary lesions of

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Objective & Hypothesis:Objectives: We investigated whether serum monocyte chemoattractant protein-1 (MCP-1) level predicted coronary atherosclerotic burden in patients with stable coronary artery disease and its relationship with coronary collateral grade.Study design: We prospectively included 196 patients (103 males, 93 females; mean age 59±11 years) who underwent coronary angiography for stable angina pectoris.
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Key Findings & Data:Serum MCP-1 levels were determined before coronary angiography.
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Conclusion & Impact:The patients were divided into four groups: those with normal coronary arteries (NCA); those with coronary lesions of
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We investigated whether serum monocyte chemoattractant protein-1 (MCP-1) level predicted coronary atherosclerotic burden in patients with stable coronary artery disease and its relationship with coronary collateral grade.Study design: We prospectively included 196 patients (103 males, 93 females; mean age 59±11 years) who underwent coronary angiography for stable angina pectoris. Serum MCP-1 levels were determined before coronary angiography. Coronary atherosclerotic burden was measured by the Gensini score, and coronary collateral development was assessed by the Rentrop classification. The patients were divided into four groups: those with normal coronary arteries (NCA); those with coronary lesions of

Özet

Amaç: Bu çalışmada serum monosit kemoatraktan protein-1 (MCP-1) düzeyinin kararlı koroner arter hastalarında koroner ateroskleroz yükünü yansıtıp yansıtmadığı ve bu durumun koroner kolateral derecesi ile ilişkisi araştırıldı. Çalışma planı: Kararlı angina pektorisi olan ve koroner anjiyografi yapılan 196 hasta (103 erkek, 93 kadın; ort. yaş 59±11) ileriye dönük olarak çalışmaya alındı. Serum MCP-1 düzeyleri anjiyografiden önce ölçüldü. Her bir hastada koroner ateroskleroz derecesi Gensini skoru, koroner kolateral gelişimi ise Rentrop sınıflandırmasına göre belirlendi. Hastalar, dört grupta değerlendirildi: Anjiyografik olarak normal koroner arterleri olanlar (NKA); lüminal daralmanın =%70 lüminal daralma ile birlikte kolateral gelişimi iyi ve kötü olan hastalar. Bulgular: Serum MCP-1 düzeyi koroner lezyon saptanan hastalarda, NKA saptanan hastalara göre daha yüksek bulundu (129±130 ve 102±55 pg/ml, p=0.048). Serum MCP-1 düzeyi, NKA olanlar, lüminal daralmanın 0.05). Sonuç: Çalışmamız, serum MCP-1 düzeyinin koroner arter hastalarında yüksek olduğunu, ancak diğer risk faktörlerinden bağımsız olarak koroner aterosklerotik yük ile ilişkili olmadığını göstermiştir. Öte yandan, kolateral gelişimi iyi olan hastalarda MCP-1 düzeyinin belirgin yüksekliği de araştırılması gereken bir konudur

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Cite This Article

TİMURKAYNAK, T., BUKAN, N., TOPAL, S., ERÇİN, U., ŞAHİNARSLAN, A., KOCAMAN, S. A. (2022). The relation of serum monocyte chemoattractant protein-1 level with coronary atherosclerotic burden and collateral degree in stable coronary artery disease. Türk Kardiyoloji Derneği Arşivi, Cilt: 39 - Sayı: 4, 269–275. https://ajindex.com/articles/633207

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