Journals / Nöropsikiyatri Arşivi / 2010 / Cilt: 47 - Sayı: 2

Migraine, white matter lesions and subarachnoid hemorrhage: Analysis of a large pedigree

Migren, ak madde lezyonları ve subaraknoid kanama: Geniş bir aile ağacının analizi

Pages
162–165
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Herein, for the first time, we report the association of this condition with familial SAH in a large pedigree.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Patients with migraine are at increased risk for white matter hyperintensities detected on magnetic resonance imaging (MRI).
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Key Findings & Data:A 46-year-old woman had a history of migraine with and without aura for 20 years.
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Conclusion & Impact:Herein, for the first time, we report the association of this condition with familial SAH in a large pedigree.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Patients with migraine are at increased risk for white matter hyperintensities detected on magnetic resonance imaging (MRI). A 46-year-old woman had a history of migraine with and without aura for 20 years. Bilateral prominent hyperintense lesions were seen in centrum semiovale, posterior corona radiata, frontal white matter and periventricular regions on her T2- and FLAIR-weighted cranial MRIs. Thirteen members of her family, including her son, had a history of migraine and similar brain MRI lesions. Furthermore, three family members had a history of subarachnoid hemorrhage (SAH) and one member had intracranial aneurysm. Our current knowledge on associations, investigation plan and treatment of patients with migraine with white matter lesions of unknown significance is limited. Herein, for the first time, we report the association of this condition with familial SAH in a large pedigree.

Özet

Migrenli hastalarda manyetik rezonans görüntülemede (MRG) ak madde hiperintensitelerin saptanma ihtimali artmıştır. Kırk altı yaşındaki kadın hastanın 20 yıldır auralı ve aurasız migreni vardı. T2 ve FLAIR ağırlıklı MRG kesitlerinde belirgin iki yanlı sentrum semiovale, posterior korona radiata, frontal ak madde ve periventriküler bölgelerde hiperintens lezyonlar görüldü. On üç aile bireyinde migren öyküsü vardı ve benzer MRG lezyonları migrenli oğlunda da görüldü. İlginç olarak üç aile bireyinde subaraknoid kanama (SAK) ve bir aile bireyinde intrakranyal anevrizma öyküsü mevcuttu. Önemi bilinmeyen ak madde lezyonları olan migrenli hastaların ilişkili olduğu durumlar, inceleme planı ve tedavileri konusundaki bugünkü bilgilerimiz sınırlıdır. Bu durumun ailesel SAK ile birlikteliği ilk kez bu çalışmada geniş bir ailede bildirilmiştir.

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Cite This Article

MATUR, Z., POYRAZ, M., UYGUNER, O., KAYSERİLİ, H., GÜVELİ, B., KAYHAN, B. (2010). Migraine, white matter lesions and subarachnoid hemorrhage: Analysis of a large pedigree. Nöropsikiyatri Arşivi, Cilt: 47 - Sayı: 2, 162–165. https://ajindex.com/articles/292726

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