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Journals / Namık Kemal Tıp Dergisi / 2018 / Cilt: 6 - Sayı: 2

Vitamin D Eksikliği Koroner Arter Hastalığı İçin Öngördürücü müdür?

CAN VITAMIN D DEFICIENCY PREDICT CORONARY ARTERY DISEASE?

ŞEREF ALPSOY
AYDIN AKYÜZ
DEMET ÖZKARAMANLI GÜR
BİROL TOPÇU
Hasan DEĞİRMENCİ
Pages
45–52
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Sigara, hipertansiyon, DDL-K ve D vitamin KAH'ın belirleyicisidirler.

📌 3 Key Takeaways

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Objective & Hypothesis:Amaç: D vitamininin ve koroner arter hastalığının (KAH) ilişkisiyle ilgili ortaya çıkan verilere dayanarak, KAH'da D vitamini ile C-reaktif protein (CRP) ile temsil edilen inflamasyon ve serum lipid profili arasında ilişki bulunup bulunmadığını araştırdık.
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Key Findings & Data:Materyal ve Metot: Yeni KAH tanısı konmuş 115 hasta ve 62 sağlıklı birey çalışmaya alındı.
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Conclusion & Impact:Sigara, hipertansiyon, DDL-K ve D vitamin KAH'ın belirleyicisidirler.
🔬Design:Research Article
📍Scope:115 hasta
⚙️Variables:Domain Parameters

Abstract

Amaç: D vitamininin ve koroner arter hastalığının (KAH) ilişkisiyle ilgili ortaya çıkan verilere dayanarak, KAH'da D vitamini ile C-reaktif protein (CRP) ile temsil edilen inflamasyon ve serum lipid profili arasında ilişki bulunup bulunmadığını araştırdık. Materyal ve Metot: Yeni KAH tanısı konmuş 115 hasta ve 62 sağlıklı birey çalışmaya alındı. Kan lipidleri, CRP ve D vitamini düzeyleri ölçüldü ve hasta ve kontrol gruplarının değerleri karşılaştırıldı. Bulgular: Hasta grubunda düşük dansiteli lipoprotein kolesterol (DDL-K), CRP ve trigliserit düzeyleri yüksek, vitamin D ve yüksek dansiteli lipoprotein kolesterol (YDLK) düşüktü. Vitamin D ile YDL-K arasında pozitif korelasyon (r=0.328; p<0.001), vitamin D ile CRP arasında negatif korelasyon (r=-0.484; p<0.001) vardı. Multivariate lojistik regresyon analizinde, sigara (p=0.001, OR = 5.301; 95% CI = 2.215 – 12.687), hipertansiyon varlığı (p=0.040, OR = 2.355; 95% CI=1.039 – 5.336), DDL-K düzeyi (p=0.048, OR =1.021, 95% CI=1.000 – 1.042) ve vitamin D düzeyi (p=0.001, OR = 0.937, 95% CI = 0.902 – 0.973) KAH belirleyicisi olarak bulundular. Sonuç: Azalmış D vitamini seviyeleri, KAH'da düşük YDL-K ve yüksek CRP seviyeleri ile ilişkilidir. Sigara, hipertansiyon, DDL-K ve D vitamin KAH'ın belirleyicisidirler.

Özet

Aim: On the basis of emerging data about the association of vitamin D and coronary artery disease (CAD), we investigated whether a relationship exists among vitamin D, inflammation represented by C-reactive protein (CRP), and serum lipid profile in CAD. Materials and Methods: Patients with newly diagnosed CAD (n = 115) and 62 healthy subjects were enrolled in the study. Blood lipids, CRP, and vitamin D levels were measured, and the patient and control groups’ values were compared. Results: The low-density lipoprotein cholesterol (LDL-C), triglyceride, and CRP levels were higher, and vitamin D and high-density lipoprotein cholesterol (HDL-C) levels were lower in the patient group. A positive correlation was found between the vitamin D and HDL-C levels (r=0.328; p<0.001) and a negative correlation was seen between vitamin D and CRP (r= -0.484; p<0.001). In the multivariate logistic regression analysis, smoking (p=0.001, OR = 5.301; 95% CI = 2.215 – 12.687), the presence of hypertension (p=0.040, OR = 2.355; 95% CI=1.039 – 5.336), LDL-C level (p=0.048, OR =1.021, 95% CI=1.000 – 1.042) and vitamin D level (p=0.001, OR = 0.937, 95% CI = 0.902 – 0.973) were found to be predictors of CAD. Conclusion: Decreased level of vitamin D is associated with presence and CAD. Decreased vitamin D levels are associated with low HDL-C and high CRP levels in CAD. Smoking, hypertension, LDL-C and vitamin D are predictors of CAD.

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Cite This Article

ALPSOY, Ş., AKYÜZ, A., GÜR, D. Ö., TOPÇU, B., DEĞİRMENCİ, H. (2018). Vitamin D Eksikliği Koroner Arter Hastalığı İçin Öngördürücü müdür?. Namık Kemal Tıp Dergisi, Cilt: 6 - Sayı: 2, 45–52. https://ajindex.com/articles/289010

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