Journals / Medical Network Klinik Bilimler Kadın Doğum / 1996 / Cilt: 2 - Sayı: 8

The metabolic changes in women who use long term gonadotropin releasing hormone for endometriosis treatment

Endometriozis nedeniyle uzun süreli gonadotropin releasing hormon agonist kullanan hastalardaki metabolik değişiklikler

Pages
102–104
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We concider D-Triptorelin to be an effective drug in the treatment of endometriosis with a low incidence of relevant side effects.

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the effects of the GnRH agonist D-Triptorelin (Decapeptyl 3.75 mg., Ferring.Switzenand) on endometriosis, 42 patients were treated with it intramuscularly over 6 months after histological verification of the disease.
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Key Findings & Data:As shown by the follow up operation at the e nd of the treatment, 72.2 % of cases showed regression of implants, whereas adhe¬sions se emed to be unaffected.
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Conclusion & Impact:We concider D-Triptorelin to be an effective drug in the treatment of endometriosis with a low incidence of relevant side effects.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

To investigate the effects of the GnRH agonist D-Triptorelin (Decapeptyl 3.75 mg., Ferring.Switzenand) on endometriosis, 42 patients were treated with it intramuscularly over 6 months after histological verification of the disease. As shown by the follow up operation at the e nd of the treatment, 72.2 % of cases showed regression of implants, whereas adhe¬sions se emed to be unaffected. Negative methabolic effects were absent in terms of hematology, clotting system, liver enzymes, re¬nal parameters and lipid methabolism. Remarcable was a significant increase of high density lipoprotein cholesterol (HDL). Subjec¬tive complaints were mostly attributed to the therapy induced hipoestrogentsm. We concider D-Triptorelin to be an effective drug in the treatment of endometriosis with a low incidence of relevant side effects.

Özet

İnsanlarda, Gn RH agonisûerinin tekrarlayın şekûde kullanılması gonadotropinlertn "down" regülasyonuna neden olmaktadır ve bu¬nun sonuçlan yalnız endokrin değil, aynı zamanda rrwtaboUktir. Uzun etktt.1 bir GnRH analoğlu olan D-Triptorelin (Decapeptyl 3.75mg, Ferring, tsviçre)Üe endometriozis tedavisi alan, altıncı ayın sonunda ikinci bakış laparaskoplsiyle endometriozisin vergiye edildiği 42 hastada: tam kan sayımı, koagülasyon profili lipid, kemik ve karaciğer metabolizmaları, renal parametreler çalışd-duAtiı ay sûreyle tedavi alan bu hastaların: karaciğer enzimleri, renal ve hematolojik parametreleri, koagülasyon profilleri, lipid dansitell lipoprotein kolesterol" de (HDL) önemli bir araş olmaktaydı. Sübjektif yakınmalar tedaviyle indûklenen hipoestrojenizme bağlandı. D-Trlptorelin yan etkilerinin azlığı ile endometriozis tedavisinde etkili bir ilaçtır.

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Cite This Article

ARSLAN, S., UĞUR, M., YEŞİLYURT, H., ŞAHİN, Y., GÖKMEN, O. (1996). The metabolic changes in women who use long term gonadotropin releasing hormone for endometriosis treatment. Medical Network Klinik Bilimler Kadın Doğum, Cilt: 2 - Sayı: 8, 102–104. https://ajindex.com/articles/282969