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Journals / Medicine Science / 2014 / Cilt: 3 - Sayı: 2

Frequency of Subclinic Hypothyroidism at the Patients That Are Using Valproic Acid

Mehmet İbrahim TURAN
Atilla ÇAYIR
İbrahim Selçuk ESİN
Yasemin ÇAYIR
Hüseyin TAN
Pages
1155–1161
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, SH is a common effect seen in children with epilepsy using VPA.

📌 3 Key Takeaways

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Objective & Hypothesis:Valproic acid is one of the most commonly used anti-epileptics in the treatment of childhood epilepsy.
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Key Findings & Data:Patients monitored with a diagnosis of idiopathic epilepsy, using valproic acid for longer than 12 months and who were seizure-free for at least 6 months were included in the study.
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Conclusion & Impact:In conclusion, SH is a common effect seen in children with epilepsy using VPA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Valproic acid is one of the most commonly used anti-epileptics in the treatment of childhood epilepsy. The aim of this study was to determine the risk factors for and incidence of subclinical hypothyroidism (SH) in children with idiopathic epilepsy using valproic acid (VPA). Patients monitored with a diagnosis of idiopathic epilepsy, using valproic acid for longer than 12 months and who were seizure-free for at least 6 months were included in the study. Levels of free thyroxine, free triiodothyronine and thyrotropin were measured. The results were then compared with those of the control group. Rates of SH in patients using VPA and the control group were 18.5% and 6.2%, respectively. The difference was statistically significant (P 0.01). In conclusion, SH is a common effect seen in children with epilepsy using VPA. It will be beneficial to measure thyroid functions at specific intervals

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Cite This Article

TURAN, M. İ., ÇAYIR, A., ESİN, İ. S., ÇAYIR, Y., TAN, H. (2014). Frequency of Subclinic Hypothyroidism at the Patients That Are Using Valproic Acid. Medicine Science, Cilt: 3 - Sayı: 2, 1155–1161. https://ajindex.com/articles/277847

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References (14)

  1. Bona G, Prodam F, Monzani A. Subclinical hypothyroidism in children: Natural history ind when to treat. J Clin Res Pediatr Endocrinol. 2013;5 Suppl 1:23-8
  2. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. Jama. 2004;291(2):228-38
  3. Demirkaya M, Sevinir B, Saglam H, Ozkan L, Akaci O. Thyroid functions in longterm survivors of pediatric hodgkin's lymphoma treated with chemotherapy and radiotherapy. J Clin Res Pediatr Endocrinol. 2011;3(2):89-94
  4. Hassan S, Qureshi W, Donthireddy V, Kuriakose P. Congenital von willebrand's disease and clinical hypothyroidism. Haemophilia. 2013;19(2):242-5
  5. Yan Z, Fan K, Fan Y, Wang X, Mao Q, Deng G, Wang Y. Thyroid dysfunction in chinese patients with chronic hepatitis c treated with interferon alpha: Incidence, longterm outcome and predictive factors. Hepat Mon. 2012;12(9):e6390
  6. Cetinkaya S, Kendirci HN, Agladioglu SY, Bas VN, Ozdemir S, Bozkurt C, Aycan Z. Hypothyroidism due to hepatic hemangioendothelioma: A case report. J Clin Res Pediatr Endocrinol. 2010;2(3):126-30
  7. Kosova F, Cetin B, Akinci M, Aslan S, Seki A, Pirhan Y, Ari Z. Serum copper levels in benign and malignant thyroid diseases. Bratisl Lek Listy. 2012;113(12):718-20
  8. Rylance GW. Treatment of epilepsy and febrile convulsions in children. Lancet. 1990;336(8713):488-91
  9. Perucca E. The new generation of antiepileptic drugs: Advantages and disadvantages. Br J Clin Pharmacol. 1996;42(5):531-43
  10. Beydoun A, D'Souza J. Treatment of idiopathic generalized epilepsy - a review of the evidence. Expert Opin Pharmacother. 2012;13(9):1283-98
  11. Verrotti A, la Torre R, Trotta D, Mohn A, Chiarelli F. Valproate-induced insulin resistance and obesity in children. Horm Res. 2009;71(3):125-31
  12. Mikati MA, Tarabay H, Khalil A, Rahi AC, El Banna D, Najjar S. Risk factors for development of subclinical hypothyroidism during valproic acid therapy. J Pediatr. 2007;151(2):178-81
  13. Verrotti A, Laus M, Scardapane A, Franzoni E, Chiarelli F. Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate. Eur J Endocrinol. 2009;160(1):81-6
  14. Sahu JK, Gulati S, Kabra M, Arya R, Sharma R, Gupta N, Kaleekal T, Reeta K, Gupta YK. Evaluation of subclinical hypothyroidism in ambulatory children with controlled epilepsy on valproate mo