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Journals / Medicine Science / 2021 / Cilt: 10 - Sayı: 2

Association between IL-4 gene polymorphisms and IL-4 serum levels in patients with allergic rhinitis

Mehmet Berkoz
Ufuk Duzenli
Yaser Said Cetin
Huseyin Ozkan
Nazim Bozan
Pages
462–468
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Genetic factors play a major role in the formation of allergic rhinitis.
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Key Findings & Data:We aimed to analyse the relation between susceptibility to allergic rhinitis and IL-4 C-590T and C+33T polymorphisms.
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Conclusion & Impact:As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Genetic factors play a major role in the formation of allergic rhinitis. The most studied genes for the investigation of the genetic origin of allergic rhinitis are the cytokine genes. We aimed to analyse the relation between susceptibility to allergic rhinitis and IL-4 C-590T and C+33T polymorphisms. For this aim, serum IL-4 levels and IL-4 C-590T and C+33T polymorphisms of 211 allergic rhinitis cases and 232 healthy individuals (control group) were analysed. We found that the individuals carrying IL-4 +33T allele and IL-4 -590TT and +33TT genotypes were much more predisposed to allergic rhinitis than the individuals carrying CC wild type genotypes. Our results also suggest that serum IL-4 levels of control group carrying the IL-4 -590 CT and TT genotypes and T allele and IL-4 +33 CT and TT genotypes, and T allele were significantly higher than the CC genotypes and T alleles carriers. As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.

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Cite This Article

Berkoz, M., Duzenli, U., Cetin, Y. S., Ozkan, H., Bozan, N. (2022). Association between IL-4 gene polymorphisms and IL-4 serum levels in patients with allergic rhinitis. Medicine Science, Cilt: 10 - Sayı: 2, 462–468. https://ajindex.com/articles/653163

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