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Dergiler / Medicine Science / 2021 / Cilt: 10 - Sayı: 2

Association between IL-4 gene polymorphisms and IL-4 serum levels in patients with allergic rhinitis

Mehmet Berkoz
Ufuk Duzenli
Yaser Said Cetin
Huseyin Ozkan
Nazim Bozan
Sayfa
462–468
Yayın Tarihi
2022-11-06
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Genetic factors play a major role in the formation of allergic rhinitis.
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Temel Bulgular & Veri:We aimed to analyse the relation between susceptibility to allergic rhinitis and IL-4 C-590T and C+33T polymorphisms.
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Sonuç & Katkı:As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Genetic factors play a major role in the formation of allergic rhinitis. The most studied genes for the investigation of the genetic origin of allergic rhinitis are the cytokine genes. We aimed to analyse the relation between susceptibility to allergic rhinitis and IL-4 C-590T and C+33T polymorphisms. For this aim, serum IL-4 levels and IL-4 C-590T and C+33T polymorphisms of 211 allergic rhinitis cases and 232 healthy individuals (control group) were analysed. We found that the individuals carrying IL-4 +33T allele and IL-4 -590TT and +33TT genotypes were much more predisposed to allergic rhinitis than the individuals carrying CC wild type genotypes. Our results also suggest that serum IL-4 levels of control group carrying the IL-4 -590 CT and TT genotypes and T allele and IL-4 +33 CT and TT genotypes, and T allele were significantly higher than the CC genotypes and T alleles carriers. As a result, it is possible to say that IL-4 C-590T and C+33T polymorphisms may increase the susceptibility of allergic rhinitis because of their lowering of IL-4 levels in serum.

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Bu Makaleye Atıf Yap

Berkoz, M., Duzenli, U., Cetin, Y. S., Ozkan, H., Bozan, N. (2022). Association between IL-4 gene polymorphisms and IL-4 serum levels in patients with allergic rhinitis. Medicine Science, Cilt: 10 - Sayı: 2, 462–468. https://ajindex.com/articles/653163

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Kaynakça (14)

  1. Julian OC, Lopez-Belio M, Dye WS, et al. The median sternal incision in intracardiac surgery with extracorporeal circulation: A general evaluation of its use in heart surgery. Surgery. 1957;42:753–61.
  2. Gatti G, Benussi B, Brunetti D, et al. The fate of patients having deep sternal infection after bilateral internal thoracic artery grafting in the negative pressure wound therapy era. Int J Cardiol. 2018;269:67–74.
  3. Bonacchi M, Prifti E, Bugetti M, et al. Deep sternal infections after in situ bilateral internal thoracic artery grafting for left ventricular myocardial revascularization: Predictors and influence on 20-year outcomes. J Thoracic Dis. 2018;10:5208–21.
  4. Reser D, Caliskan E, Tolboom H, et al. Median Sternotomy. Multimedia manual of cardiothoracic surgery. MMCTS. 2015;2015.
  5. Brandenburg VM, Vervloet MG, Marx N. The role of vitamin D in cardiovascular disease: From present evidence to future perspectives. Atherosclerosis. 2012;225:253–63.
  6. Skaaby T, Thuesen BH, Linneberg A. Vitamin D, cardiovascular disease and risk factors. Adv Exp Med Biol. 2017;996:221-30.
  7. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: When to test and how to treat. Vol. 85, Mayo Clinic Proceedings. Elsevier Ltd. 2010. p.752–8.
  8. Lips P, Bouillon R, van Schoor NM, et al. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010;73:277-85.
  9. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metabol. (Oxf). 2011;7:1911–30.
  10. Bejko J, Tarzia V, de Franceschi M, et al. Nitinol flexigrip sternal closure system and chest wound infections: Insight from a comparative analysis of complications and costs. Ann Thorac Surg. 2012;94:1848-53.
  11. Raman J, Lehmann S, Zehr K, et al. Sternal closure with rigid plate fixation versus wire closure: A randomized controlled multicenter trial. Ann Thorac Surg. 2012;94:1854-61.
  12. Schindeler A, McDonald MM, Bokko P, et al. Bone remodeling during fracture repair: The cellular picture. Vol. 19, Seminars in Cell and Developmental Biology. Elsevier Ltd. 2008. p. 459–66.
  13. Lee BNR, Kim TH, Jun JB, et al. Upregulation of interleukin-1β production by 1,25-Dihydroxyvitamin D3 in activated human macrophages. Mol Bio Rep. 2011;38:2193–201.
  14. Zarrabeitia MT, Riancho JA, Amado JA, et al. Effect of calcitriol on the secretion of prostaglandin E2, interleukin 1, and tumor necrosis factor α by human monocytes. Bone. 1992;13