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Journals / Medicine Science / 2020 / Cilt: 9 - Sayı: 2

The relation between lead exposure and inflammation / endothelial dysfunction

Lütfiye TUTKUN
Meside GÜNDÜZÖZ
Özgür ÖZTAN
VUGAR ALİ TÜRKSOY
Mehmet Erdem ALAGÜNEY
Servet Birgin İRİTAŞ
Pages
468–472
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Association between lead exposure and markers of cardiovascular injury may help to predict cardiovascular effects of lead earlier and to protect workers who are exposed to lead.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pb exposure is a well-known risk factor for inflammation including vessels.
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Key Findings & Data:There was a significant correlation between blood lead levels and vascular cell adhesion molecule-1 (VCAM-1).
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Conclusion & Impact:Association between lead exposure and markers of cardiovascular injury may help to predict cardiovascular effects of lead earlier and to protect workers who are exposed to lead.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Pb exposure is a well-known risk factor for inflammation including vessels. In our study, we aimed to investigate the relationship between Pb levels of exposed workers and the severity of inflammation/endothelial dysfunction. We analyzed the correlation between blood lead level and the markers of endothelial damage. There was a significant correlation between blood lead levels and vascular cell adhesion molecule-1 (VCAM-1). Elevated levels of blood lead also show correlation with soluble CD40 ligand (sCD40L). The strongest correlation was with sE-selectin. Association between lead exposure and markers of cardiovascular injury may help to predict cardiovascular effects of lead earlier and to protect workers who are exposed to lead.

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Cite This Article

TUTKUN, L., GÜNDÜZÖZ, M., ÖZTAN, Ö., TÜRKSOY, V. A., ALAGÜNEY, M. E., İRİTAŞ, S. B. (2020). The relation between lead exposure and inflammation / endothelial dysfunction. Medicine Science, Cilt: 9 - Sayı: 2, 468–472. https://ajindex.com/articles/272618

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References (14)

  1. Yusuf S, Ounpuu S. Tackling the growing burden of atherosclerotic cardiovascular diseases. Eur J Cardiovasc Prev Rehabil. 2003;10:236-9
  2. Kim H, Kim S, Han S, et al. Prevalence and incidence of atherosclerotic cardiovascular disease and its risk factors in Korea: a natiowide populationbased study. BMC Pub Health. 2019;19:1112
  3. Amer MS, Khater MS, Omar OH, et al. Association between Framingham score and subclinical atherosclerosis among elderly with both type 2 diabetes mellitus and healthy subjects. Am J Cardiovasc Dis. 2014;4:14-9
  4. Arsenault J, Rana JS, Lemieux I, et al. Physical activity, the Framingham risk score and risk of coronary heart diseases in men and women of the EPIC-Norfolk study. Atherosclerosis. 2010;209:261-5
  5. Ji X, Leng X, Dong Y, et al. Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review. Ann Transl Med. 2019;7:632
  6. Bress AP, Colantonio LD, Booth JN, et al. Modifiable risk factors versus age on developing high predicted cardiovascular disease risk in blacks. J Am Heart Assoc. 2017;6:pii:e005054
  7. Stefanidis C, Antoniou CK, Tsiachris D, et al. Coronary atherosclerotic vulnerable plaque: Current perspectives. 2017;6:e005543
  8. Nakagawa K, Nakashima Y. Pathological intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells. Atherosclerosis. 2018;274:235-42
  9. Back M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nar Rev Cardiol. 2019;16:389-406
  10. Hicken MT, Adar SD, Hajat A, et al. Air pollution, cardiovascular outcomes, and social disadvantage: The Multiethnic Study of Atherosclerosis. Epidemiology. 2016;27:42-50
  11. Asgary S, Movahedian A, Keshvari M, et al. Serum levels of lead, mercury and cadmium in relation to coronary artery disease in the elderly: A crosssectional study. Chemosphere. 2017;180:540-4
  12. Barry V, Steenland K. Lead exposure and mortality among US workers in a surveillance program: Results from 100 additional years of follow-up. Environ Res. 2019;177:108625
  13. Hwang SJ, Ballantyne CM, Sharrett AR, et al. Circulating adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart diseases cases: The Atherosclerosis Risk in Communities (ARIC) study. Circulation. 1997;96:4219-25
  14. Peter K, Weirich U, Nordt TK, et al. Soluble vascular cell adhesion