Journals / JAREM / 2019 / Cilt: 9 - Sayı: 1

Relationship Between Erectile Dysfunction, the Neutrophil-to-Lymphocyte Ratio, and the Platelet-to-Lymphocyte Ratio

Erektil Disfonksiyon ile Nötrofil Lenfosit Oranı ve Trombosit Lenfosit Oranı Arasındaki İlişki

Journal
JAREM
Pages
27–31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The NLR value may be related to ED, and it can give valuable information in patients with ED.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Various chronic diseases, including hypertension (HT), diabetes mellitus (DM), and coronary artery disease (CAD), together with the medications used in the treatment of these conditions, are considered a part of the erectile dysfunction (ED) etiology.
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Key Findings & Data:The NLR and PLR increase in systemic inflammation, certain gynecological and gastrointestinal cancers, CAD, various oncological diseases, and especially in acute coronary syndromes.
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Conclusion & Impact:The NLR value may be related to ED, and it can give valuable information in patients with ED.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Various chronic diseases, including hypertension (HT), diabetes mellitus (DM), and coronary artery disease (CAD), together with the medications used in the treatment of these conditions, are considered a part of the erectile dysfunction (ED) etiology. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) provide information about many diseases. The NLR and PLR increase in systemic inflammation, certain gynecological and gastrointestinal cancers, CAD, various oncological diseases, and especially in acute coronary syndromes. In this study, the relationship between PLR, NLR, and ED severity were examined in patients with ED. Methods: All data from patients were screened retrospectively. Body mass index, the International Index of Erectile Function-5 (IIEF-5) scores, age, fasting blood glucose, whole blood count, lipid, and hormone profile values were measured. The PLR and NLR values from both the patient and control groups were evaluated. The IIEF-5 questionnaire was used to measure the quality of erection in all the groups. A total of 131 patients with ED were divided into four groups: severe (34 patients), moderate (32 patients), mild-to-moderate (36 patients), and mild ED (29 patients). In addition, a control group was formed with 26 healthy men. Results: No statistically significant difference was observed between the groups in terms of the mean age, hypertension, smoking status, alcohol use, DM, CAD, and cholesterol and triglycerides levels. The mean PLR values were 125.3±41.4, 120.6 ±36.1, 118.2±50.4, 104.9±3.2, and 107.5±37.4 in the severe, moderate, mild-to-moderate, mild ED, and control groups, respectively. There was no significant difference in the PLR ratio among the ED groups and controls (p>0.05). The mean NLR values were 2.40±1.22, 2.34±0.88, 2.26±1.22, 2.1±0.87, and 1.76±0.7 in the severe, moderate, mild-to-moderate, mild ED, and control groups, respectively. Compared with the control group, this value was statistically significant for patients with all ED groups (p<0.05). Conclusion: The NLR value was found to be higher in patients with ED. The NLR value may be related to ED, and it can give valuable information in patients with ED.

Özet

Amaç: Erektil disfonksiyon (ED) etyolojisinde; hipertansiyon (HT), diabetes mellitus (DM) ve koroner arter hastalığı (KAH) dahil çeşitli kronik hastalıklar ile bu hastalıkların tedavisinde kullanılan ilaçlar olduğu düşünülmektedir. Nötrofil - lenfosit oranı (NLO) ve trombosit - lenfosit oranı (TLO) birçok hastalık hakkında bilgi vermektedir. NLO ve TLO, sistemik inflamasyon, bazı jinekolojik ve gastrointestinal kanserler, koroner arter hastalıkları, çeşitli onkolojik hastalıklar ve özellikle akut koroner sendromda artmaktadır. Bu çalışmada, ED hastalarında TLO, NLO ve ED şiddeti arasındaki ilişki araştırıldı. Yöntemler: Hastalardan alınan tüm veriler retrospektif olarak tarandı. Vücut kütle indeksi (VKİ), Uluslararası Erektil İşlev İndeksi-5 (IIEF-5) skorları, yaş, açlık kan şekeri, tam kan sayımı, lipit ve hormon profili değerleri ölçüldü. Hem hasta hem de kontrol gruplarından TLO ve NLO sonuçları değerlendirildi. Tüm gruplarda ereksiyon derecesini değerlendirmek için Uluslararası Erektil İşlev İndeks (IIEF-5) anketi kullanıldı. ED ile başvuran toplam 131 hasta; şiddetli ED (34 hasta), orta ED (32 hasta), hafif-orta ED (36 hasta) ve hafif ED (29 hasta) olmak üzere dört gruba ayrıldı. Ayrıca 26 sağlıklı erkek ile kontrol grubu oluşturuldu. Bulgular: Ortalama yaş, hipertansiyon, sigara içme durumu, alkol kullanımı, DM, KAH, ile kolesterol ve trigliserit düzeyleri açısından gruplar arasında istatistiksel olarak anlamlı bir fark yoktu. Ortalama TLO değeri şiddetli, orta, hafif-orta, hafif ED ve kontrol gruplarında sırasıyla 125,3±41,4, 120,6±36,1, 118,2±50,4, 104,9±34,2, 107,5±37,4 idi. ED grupları ve kontroller arasında TLO oranında anlamlı fark yoktu (p>0,05). Ortalama NLO değerleri sırasıyla şiddetli, orta, hafif-orta, hafif derecede ED ve kontrol gruplarında; 2,40±1,22, 2,34±0,88, 2,26±1,22, 2,1±0,87, 1,76±0,7 idi. Kontrol grubuyla karşılaştırıldığında, bu değerler tüm ED grubu hastalarda istatistiksel olarak anlamlı bulundu (p<0,05). Sonuç: ED hastalarında NLO değeri daha yüksek bulundu. NLO değeri ED ile ilişkili olabilir ve ED hastalarında değerli bilgiler verebilir.

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Cite This Article

KARABAKAN, M., BOZKURT, A. (2019). Relationship Between Erectile Dysfunction, the Neutrophil-to-Lymphocyte Ratio, and the Platelet-to-Lymphocyte Ratio. JAREM, Cilt: 9 - Sayı: 1, 27–31. https://ajindex.com/articles/270375

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