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Journals / İzmir Tepecik Eğitim Hastanesi Dergisi / 2008 / Cilt: 18 - Sayı: 2

The effect of uncomplicated percutaneus coronary intervention on brachial artery flow mediated dilatation in patients with stable angina pectoris

Stabil angina pektorisi olan hastalarda komplikasyonsuz perkütan koroner girişiminin brakiyal arterin akımla uyarılan dilatasyonu üzerine etkisi

Selçuk PALA
Mustafa AKÇAKOYUN
Ramazan KARGIN
Zekeriya KAYA
Cevat KIRMA
Özlem ESEN
Yunus EMİROĞLU
Hekim KARAPINAR
Pages
0–0
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Although there were a slight increase in serum hs-CRP levels following uncomplicated percutaneous coronary intervention of patients with stable angina pectoris, brachial artery flow mediated dilation was not impaired.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: It is well known that systemic inflammation impairs endothelial function.
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Key Findings & Data:MATETRIAL AND METHOD: Forty patients with stable angina pectoris (SAP), (30 male, 10 female, mean age: 56±10 years) with normal basal inflammation markers who had uncomplicated PCI were admitted to study. hs-CRP and BAFMD were measured before and 48 hours after PCI.
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Conclusion & Impact:CONCLUSION: Although there were a slight increase in serum hs-CRP levels following uncomplicated percutaneous coronary intervention of patients with stable angina pectoris, brachial artery flow mediated dilation was not impaired.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: It is well known that systemic inflammation impairs endothelial function. However, it is not clear whether uncomplicated percutaneus coronary intervention (PCI) causes endothelial dysfunction. The aim of this study was to investigate the effects of uncomplicated PCI on systemic inflammation and brachial artery flow mediated dilation (BAFMD) in patients with stable angina pectoris. MATETRIAL AND METHOD: Forty patients with stable angina pectoris (SAP), (30 male, 10 female, mean age: 56±10 years) with normal basal inflammation markers who had uncomplicated PCI were admitted to study. hs-CRP and BAFMD were measured before and 48 hours after PCI. RESULTS: There was a slight increase in hs-CRP levels after PCI (0,243 ±0,105 vs 0,434 ±0,130 mg/dl, p<0,0001). However, there were no statistically significant differences in BAFMD before and after PCI (%7,5 ±2,2 vs %7,1 ± 2,6, p>0,05). CONCLUSION: Although there were a slight increase in serum hs-CRP levels following uncomplicated percutaneous coronary intervention of patients with stable angina pectoris, brachial artery flow mediated dilation was not impaired.

Özet

AMAÇ: Sistemik inflamasyonun endotel işlevini bozduğu bilinmektedir. Bununla beraber, komplikasyonsuz perkütan koroner girişim (PKG)'in endotel işlevini bozup bozmadığı kesin olarak bilinmemektedir. Bu çalışmada stabil anjina pektorisi (SAP) olan hastalarda yapılan komplikasyonsuz PKG'in sistemik inflamasyon ve brakiyal arterin akımla uyarılan vazodilatasyonu (AUV) üzerine etkisi araştırılmıştır. GEREÇ VE YÖNTEM: PKG yapılan ve temel inflamasyon markırları normal bulunan, stabil anjina pektoris (SAP) kliniği olan 40 hasta (30 erkek 10 kadın, yaş ortalaması 56±10) ile çalışma tamamlandı. hs-CRP ve brakiyal arter AUV'u PKG öncesi ve PKG'den 48 saat sonra ölçüldü. BULGULAR: PKG sonrası hs-CRP düzeylerinde hafif artış izlendi (0,243 ±0,105 mg/dl ve 0,434 ±0,130 mg/dl, p 0,05). SONUÇ: Stabil anjina pektorisli hastalarda yapılan komplikasyonsuz perkütan koroner girişim sonrası, serum hs-CRP düzeylerinde hafif düzeyde artış olmakla birlikte brakiyal arterin akımla uyarılan dilatasyonu bozulmamaktadır.

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Cite This Article

PALA, S., AKÇAKOYUN, M., KARGIN, R., KAYA, Z., KIRMA, C., ESEN, Ö., EMİROĞLU, Y., KARAPINAR, H. (2008). The effect of uncomplicated percutaneus coronary intervention on brachial artery flow mediated dilatation in patients with stable angina pectoris. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 18 - Sayı: 2, 0–0. https://ajindex.com/articles/268454

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