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Journals / Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi / 2012 / Cilt: 7 - Sayı: 1

Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures

Asetonitril-Su İkili Karışımlarında Piroksikam ve Tenoksikam'ın Potansiyometrik pKa Tayini

Ebru Çubuk Demiralay
Hülya Yılmaz
Pages
34–44
Publication Date
2012-06-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ionization constant (pKa) is one among the parameter to be estimated with accuracy, irrespective of solubility constraints.
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Key Findings & Data:By using the potentiometric method, pKa values of piroxicam and tenoxicam have been determined in different percentage of acetonitrile-water binary mixtures (acetonitrile content between 30 and 45% in volume).
💡
Conclusion & Impact:The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Potansiyometrik titrasyonlar · Asetonitril · pKa

Abstract

Ionization constant (pKa) is one among the parameter to be estimated with accuracy, irrespective of solubility constraints. In the present study, acid-base behaviour of the piroxicam and tenoxicam was studied. By using the potentiometric method, pKa values of piroxicam and tenoxicam have been determined in different percentage of acetonitrile-water binary mixtures (acetonitrile content between 30 and 45% in volume). Aqueous pKa values of these compounds were calculated by mole fraction and Yasuda - Shedlovsky equations. The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages.

Özet

İyonlaşma sabiti (pKa) çözünebilirlik sınırlaması olmaksızın doğru tahmin edilebilen parametrelerden birisidir. Sunulan bu çalışmada, piroksikam ve tenoksikamın asit- baz davranışı çalışılmıştır. Potansiyometrik metot kullanılarak, piroksikam ve tenoksikamın pKa değerleri asetonitril-su ikili karışımlarının farklı yüzdelerinde tayin edilmiştir (asetonitril içeriği hacimce % 30 ile 45 arasında). Bu bileşiklerin sudaki pKa değerleri mol kesri ve Yasuda-Shedlovsky eşitlikleri kullanarak hesaplanmıştır. Deneysel pKa değerleri SPARC and Marvin Sketch paket programlarından türetilmiş tahmini değerlerle karşılaştırılmıştır.

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Cite This Article

Demiralay, E. Ç., Yılmaz, H. (2012). Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures. Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, Cilt: 7 - Sayı: 1, 34–44. https://ajindex.com/articles/261131

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