Journals / European Oral Research / 2014 / Cilt: 48 - Sayı: 2

Leukocyte and Platelet Rich Fibrin: Characteristics and Clinical Applications in Dentistry

LÖKOSİT VE TROMBOSİTTEN ZENGİN FİBRİNİN ÖZELLİKLERİ VE DİŞ HEKİMLİĞİNDE KULLANIM ALANLARI

Pages
73–83
Publication Date
2014-06-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Frequency of L-PRF usage in dentistry is increasing, because of its positive effects on soft tissue and bone healing.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Several platelet concentrates are avaliable in different techniques; however, their biological contents vary from one to another.
📊
Key Findings & Data:Leukocyte platelet-rich fibrin (L-PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling.
💡
Conclusion & Impact:Frequency of L-PRF usage in dentistry is increasing, because of its positive effects on soft tissue and bone healing.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Trombositten zengin fibrin · yara iyileşmesi · büyüme faktörü

Abstract

Several platelet concentrates are avaliable in different techniques; however, their biological contents vary from one to another. Leukocyte platelet-rich fibrin (L-PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. Although plateletderived growth factors play an important role in biology of PRF, fibrin organization and the leukocyte content are other two key variables. Due to the growth factor and cell content, L-PRF has a positive effect on natural wound healing. Frequency of L-PRF usage in dentistry is increasing, because of its positive effects on soft tissue and bone healing.

Özet

Günümüzde çeşitli tekniklerle elde edilen farklı trombosit konsantrasyonları bulunmaktadır. Benzer isimlerle anılsa bile, bu konsantrasyonların biyolojik içerikleri farklıdır. Lökosit ve trombositten zengin fibrin (L-TZF), kan kaynaklı trombosit konsantrasyonları arasında en son geliştirilenidir. Herhangi bir antikoagülan ajana gerek duyulmadan hazırlanan L-TZF’nin eldesi kolaydır. L-TZF’nin biyolojisinde her ne kadar trombosit kaynaklı büyüme faktörleri önemli bir rol oynasa da, fibrin organizasyonu ve lökosit içeriği de diğer iki anahtar değişkenini oluşturur. Bu nedenle L-TZF, içeriğinde bulunan büyüme faktörleri ve hücreler sayesinde doğal yara iyileşmesini olumlu yönde etkiler. Yumuşak doku ve kemik iyileşmesi üzerindeki olumlu özellikleri nedeniyle günümüzde L-TZF’nin diş hekimliği alanında kullanım sıklığı giderek artmaktadır.

🔖

Cite This Article

EREN, G., ATİLLA, G. (2014). Leukocyte and Platelet Rich Fibrin: Characteristics and Clinical Applications in Dentistry. European Oral Research, Cilt: 48 - Sayı: 2, 73–83. https://ajindex.com/articles/243182

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost 2006;4(5):932-9.
  2. Carlson NE, Roach RB Jr. Platelet rich plasma: clinical applications in dentistry. J Am Dent Assoc 2002;133(10):1383-6.
  3. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85(6):638-46.
  4. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet cancentrates: from pure plateletrich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27(3):158-67. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14(4):529-35.
  5. Tamimi FM, Montalvo S, Tresguerres I, Blanco Jerez L. A comparative study of two methods for obtaining plateletrich plasma. J Oral Maxillofac Surg 2007;65(6):1084-93.
  6. Clausen, C, Hermund NU, Donatsky O, Nielsen H, Osther K. Homologous activated platelets stimulate differentiation and proliferation of primary human bone cells. Cells Tissues Organs 2006;184(2):68–75.
  7. Krasna, M, Domanović D, Tomsic A, Svajger U, Jeras M. Platelet gel stimulates proliferation of human dermal fibroblasts in vitro. Acta Dermatovenerol Alp Panonica Adriat 2007;16(3):105–10.
  8. Anitua, E, Andía I, Sanchez M, Azofra J, del Mar Zalduendo M, de la Fuente M, Nurden P, Nurden AT. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 2005;23(2):281–6.
  9. Akeda, K, An HS, Okuma M, Attawia M, Miyamoto K, Thonar EJ, Lenz ME, Sah RL, Masuda K. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage 2006;14(12):1272–80.
  10. Okuda, K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H, Wolff LF, Yoshie H. Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol 2003;74(6):849–57.
  11. Lucarelli, E, Beccheroni A, Donati D, Sangiorgi L, Cenacchi A, Del Vento AM, Meotti C, Bertoja AZ, Giardino R, Fornasari PM, Mercuri M, Picci P. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003;24(18):3095–100.
  12. Cenni, E, Ciapetti G, Pagani S, Perut F, Giunti A, Baldini N. Effects