Short term effects of topical latanoprost 0.005%) on tear film

Key Findings & Data:Material and Methods: 20 eyes of 20 patients who had been diagnosed as primary open angle glaucoma and undergone anti-glaucoma treatment, were included in this study.

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Conclusion & Impact:Conclusion: Topical latanoprost (0.005%) may increase tear break-up time in short term use.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Purpose: To investigate effects of topical latanoprost (0.005%) on tear film. Material and Methods: 20 eyes of 20 patients who had been diagnosed as primary open angle glaucoma and undergone anti-glaucoma treatment, were included in this study. Basal Schirmer test, tear break-up time, Rose Bengal, and ocular surface disease index were applied for all of the cases before topical latanoprost therapy. All of the tests were repeated in 1st, 2nd and 3rd month of the treatment. All results were evaluated with nonparametric Wilcoxon test by SPSS 13.0. Results: Mean age was 51.8±6.4 (SD) (12\8 Female\Male). Mean scores were established as Schirmer 9.5±3.3 mm, tear break-up time 12.4±3 sec, Rose Bengal 3.85±2, ocular surface disease index 49.53±20 before the terapy. There’s no significant changes in Schirmer, Rose Bengal and ocular surface disease index score in 1st, 2nd and 3rd month of the treatment but a significant increase was observed in tear break-up time 13.6±2 (p=0.007) at the 2nd and 13.9±1.8 (p=0.004) 3rd month. Conclusion: Topical latanoprost (0.005%) may increase tear break-up time in short term use.

Özet

Amaç: Topikal latanoprostun (%0.005) kullanımının gözyaşı filmine etkilerini araştırmak. Gereç ve Yöntem: Çalışmaya primer açık açılı glokom tanısı yeni koyulup tedaviye başlanan 20 olgunun 20 gözü dahil edildi. Topikal latanoprost (%0.005) tedavisi başlamadan önce tüm olgulara bazal schirmer, gözyaşı kırılma zamanı, rose bengal testi ve oküler yüzey hastalığı indeksi skorlaması yapıldı. Tedavinin devamında 1, 2 ve 3. aylarda aynı testler tekrar yapıldı. Tüm sonuçlar SPSS 13.0 ile non parametrik Wilcoxon testi ile değerlendirildi. Bulgular: Olguların yaş ortalaması 51.8±6.4 (SD) (12\8 Kadın\ Erkek) idi. Tedavi başlamadan önce olguların ortalama Schirmer 9.5±3.3 mm, gözyaşı kırılma zamanı 12.4±3 sn, Rose Bengal skoru 3.85 ±2, oküler yüzey hastalığı indeksi skoru 49.53±20 olarak saptandı. Olguların 1, 2 ve 3. ayda yapılan takiplerinde schirmer testi, Rose Bengal ve oküler yüzey hastalığı indeksi skorunda anlamlı bir bulgu tespit edilemedi. Göz yaşı kırılma zamanında ise anlamlı bir artış olduğu [2. ay 13.6±2 (p=0.007), 3. ay 13.9±1.8 (p=0.004)] gözlemlendi. Sonuç: Topikal latanoprostun (%0.005) kısa dönem kullanımı gözyaşı kırılma zamanının uzamasına neden olabilmektedir.

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Cite This Article

YILDIZ, A. A., BARDAK, Y., TIĞ, U. Ş. (2010). Short term effects of topical latanoprost 0.005%) on tear film. Glokom Katarakt, Cilt: 5 - Sayı: 1, 38–42. https://ajindex.com/articles/226571

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