Hematologic, immunologic and bıochemical evaluation in normal tension glaucoma

Objective & Hypothesis:Purpose: To purpose of our study was to evaluate possible hematologic, immunologic and biochemical findings in normal tension glaucoma (NTG) cases.

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Key Findings & Data:Material and Methods: The study groups included 32 patients who were followed at the Glaucoma Section of Ankara University Department of Ophthalmology between April 2005-December 2007.

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Conclusion & Impact:High levels of lipids in NTG patients, considered that several mechanisms play a role together in the patogenesis.

🔬Design:Research Article

📍Scope:2005 Verileri

⚙️Variables:Domain Parameters

Abstract

Purpose: To purpose of our study was to evaluate possible hematologic, immunologic and biochemical findings in normal tension glaucoma (NTG) cases. Material and Methods: The study groups included 32 patients who were followed at the Glaucoma Section of Ankara University Department of Ophthalmology between April 2005-December 2007. The control group consisted of 26 subjects who had no ocular disease. Blood samples were taken in the appropriate tubes from all participants for complete blood count, lipid profile, coagulation tests and immunological tests. Results: In NTG cases, mean thrombocyte, mean low density lipoprotein (LDL), and mean total cholesterol levels were significantly higher than control group (p=0.041, 0.047, 0.046 respectively). Furthermore, number of patients whose LDL, very low density lipoprotein (VLDL), and total cholesterol levels are higher than normal levels, was significiantly higher in NTG group (p=0.043, p=0.025, p=0.048 respectively). Conclusions: NTG etiopatogenesis is not completely understood recently. High levels of lipids in NTG patients, considered that several mechanisms play a role together in the patogenesis.

Özet

Amaç: Normal basınçlı glokom (NBG) olgularında olası hematolojik, immünolojik ve biyokimyasal belirteçlerin değerlendirilmesi. Gereç ve Yöntem: Ankara Üniversitesi Göz Hastalıkları Anabilim Dalı Glokom Biriminde Nisan 2005-Aralık 2007 tarihleri arasında tanı konan ve takip edilen 32 NBG olgusu ve bilinen bir göz hastalığı olmayan, rutin kontrol için polikliniğe başvuran 26 olgu, kontrol grubu olarak çalışmaya alındı. Tüm katılımcılardan tam kan sayımı, lipid profili, koagulasyon testleri, immunolojik testler için uygun tüplere kan örnekleri alındı. Bulgular: NBG'lu hastalarda trombosit, düşük yoğunluklu lipoprotein (LDL) ve total kolesterol ortalama düzeyleri kontrol grubundan anlamlı şekilde yüksek bulundu (sırasıyla p=0.041, 0.047, 0.046). Ayrıca LDL, çok düşük yoğunluklu lipoprotein (VLDL), total kolesterol düzeyleri normal sınırdan yüksek olan kişi sayısı da NBG grubunda anlamlı şekilde daha yüksekti (sırasıyla p=0.043, p=0.025, p=0.048). Sonuç: NBG etiyopatogenezi henüz tam olarak anlaşılamamıştır. Lipid değerlerinin NBG'lu hastalarda yüksek olması, patogenezde birçok mekanizmanın birlikte rol oynadığını düşündürmektedir.

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Cite This Article

İNCEL, O., TEKELİ, O., TURAÇLI, E. (2010). Hematologic, immunologic and bıochemical evaluation in normal tension glaucoma. Glokom Katarakt, Cilt: 5 - Sayı: 4, 223–227. https://ajindex.com/articles/226544

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