Journals / Glokom Katarakt / 2011 / Cilt: 6 - Sayı: 4

Retinal nerve fiber layer thickness obtained by optical coherence tomography in healthy preschool age children

Okul öncesi yaş grubundaki sağlıklı çocuklarda optik koherens tomografi ile elde edilen retina sinir lifi kalınlığı

Pages
239–245
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Age, axial length, and optic disc morphology of the children may affect the measurements whereas no significant effect of gender on the measurements.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To determine the normative values of retinal nerve fiber layer (RNFL) thicknesses obtained by optical coherence tomography (OCT) in healthy preschool age children and to investigate the effects of age, sex, axial length, and optic disc morphology on the measurements.
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Key Findings & Data:Materials and Methods: One hundred and seventy two eyes of 111 healthy children with age between 3 and 6 were measured for optic disc morphology and RNFL thicknesses by OCT.
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Conclusion & Impact:Age, axial length, and optic disc morphology of the children may affect the measurements whereas no significant effect of gender on the measurements.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To determine the normative values of retinal nerve fiber layer (RNFL) thicknesses obtained by optical coherence tomography (OCT) in healthy preschool age children and to investigate the effects of age, sex, axial length, and optic disc morphology on the measurements. Materials and Methods: One hundred and seventy two eyes of 111 healthy children with age between 3 and 6 were measured for optic disc morphology and RNFL thicknesses by OCT. The measurement of axial length and routine eye examination were performed in all eyes. Data was statistically analyzed. Results: Fifty three of 111 healthy children were female and 58 were male. The mean age of the children was 57.48±11.87months. The means of Global RNFL (G-RNFL), superior RNFL (S-RNFL), inferior RNFL (I-RNFL), temporal RNFL (T-RNFL), and nasal RNFL (N-RNFL) were 105.5±11.5 μm; 131.08±19.14 μm; 132.38±20.10 μm; 76.0±14.90 μm and 82.88±17.85 μm, respectively. Girls' RNFL was thinner than the boys', but this difference was not statistically significant. There were negative correlations between age and all parameters of RNFL measurement except nasal RNFL. The only parameter, that has statistically significant correlation between age, was T-RNFL (r=-0,.213, p=0.011). Also,there were statistically significant negative correlations between axial length and the thicknesses of S-RNFL, I-RNFL, and G-RNFL (r=-0.245, p=0.004; r=-0.243, p=0.004; r=-0.255, p=0.002; respectively). Positive correlations between rim area and the thicknesses of S-RNFL, I-RNFL, and G-RNFL were significant (r=0.205, p=0.015; r=0.183, p=0.03; r=0.251, p=0.003; respectively). Conclusion: The normative values of RNFL thicknesses in preschool age children were found thinner than the black and Asian children's values, and similar to white children's. Age, axial length, and optic disc morphology of the children may affect the measurements whereas no significant effect of gender on the measurements.

Özet

Amaç: Okul öncesi yaş grubundaki sağlıklı çocuklarda optik koherens tomografi (OKT) ile elde edilen retina sinir lifi tabakası(RSLT) kalınlığının normatif değerlerini belirlemek ve yaş, optik disk morfolojisi, aksiyel uzunluk ve cinsiyetin ölçümler üzerindeki etkilerini incelemek. Gereç ve Yöntem: Yaşları 3 ile 6 arasında değişen 111 sağlıklı çocuğun 172 gözü çalışmaya alınarak OKT ile optik disk morfolojisi ve RSLT kalınlıkları incelendi. Tüm olgulara, rutin göz muayenesi ile birlikte aksiyel uzunluk ölçümü yapıldı. Elde edilen veriler istatistiksel olarak değerlendirildi. Bulgular: Çalışmaya alınan 111 çocuğun 53'ü kız (%47.7), 58'i erkek (%52.3) olup, yaş ortalaması 57.48±11.87 aydı (30 ile 80 ay arası). Elde edilen ortalama (global) RSLT kalınlığı 105.5±11.5 μm olup; superior (S-RSLT), inferior (I-RSLT), temporal(T-RSLT) ve nazal (N-RSLT) RSLT kalınlıklarının ortalaması sırasıyla; 131.08±19.14 μm, 132.38±20.10 μm, 76.04±14.90 μm ve 82.88±17.85 μm olarak tespit edildi. RSLT kalınlığı, kız çocuklarda erkeklerden daha inceydi, fakat fark istatistiksel olarak anlamlı bulunmadı. Nazal kadran dışındaki tüm RSLT kalınlık parametreleri ile yaş arasında zayıf bir negatif ilişki saptandı. İstatistiksel olarak anlamlılık sadece yaş ile temporal RSLT kalınlığı arasındaydı (r=-0.213, p=0.011). Aksiyel uzunluk ile S-RSLT, I-RSLT ve ort-RSLT kalınlık değerleri arasında istatistiksel olarak anlamlı negatif bir ilişki saptandı (sırasıyla; r=-0.245, P=0.004; r=-0.243, p=0.004; r=-0.255, P=0.002). Rim alanı ile superior, inferior ve ort. RSLT kalınlıkları arasında istatistiksel olarak anlamlı pozitif ilişki bulundu (sırasıyla; r=0.205, p=0.015; r=0.183, p=0.03; r=0.251, p=0.003). Sonuç: Çalışmamızda yer alan okul öncesi yaş grubundaki sağlıklı çocukların RSLT kalınlık değerlerinin, siyah ve uzak doğulu çocuklardan daha ince ve beyaz çocukların değerlerine daha yakın olduğu saptandı. Yaş, aksiyel uzunluk ve optik disk morfolojisinin ölçümler üzerinde etkisi olduğu görülürken, cinsiyetin ölçümler üzerinde anlamlı etkisinin olmadığı tespit edildi.

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Cite This Article

YETER, V., ARITÜRK, N. (2011). Retinal nerve fiber layer thickness obtained by optical coherence tomography in healthy preschool age children. Glokom Katarakt, Cilt: 6 - Sayı: 4, 239–245. https://ajindex.com/articles/226507

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