SavedAdd your journal

Journals / Glokom Katarakt / 2011 / Cilt: 6 - Sayı: 4

Affect of ıntraocular pressure change on ocular pulse amplitude in normal and glaucomatous eyes

Normal ve glokomlu olgularda göz içi basınç değişiminin oküler nabız basıncı üzerindeki etkisi

Ebru CÖMERT
Ümit BEDEN
Mehtap ÖZARSLAN
Barış SÖNMEZ
İhsan ÖGE
Dilek ERKAN
Pages
230–234
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Normal eyes had insignificantly lower OPA values, which decrease significantly more than in glaucomatous eyes with IOP lowering. (p=0.04) Conclusion: IOP change has a more effect on OPA in normal than in glaucomatous eyes statistically.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: To assess the affect of intraocular pressure (IOP) change on ocular pulse amplitude (OPA) in normal and glaucomatous eyes.
📊
Key Findings & Data:Materials and Methods: IOP and OPA of 55 eyes with open angle glaucoma and 51 control eyes were recorded both before and after topical application of apraclonidin or dorzolamide so as to measure baseline and differential OPA in normal and glaucomatous eyes by using dynamic contour tonometers.
💡
Conclusion & Impact:Normal eyes had insignificantly lower OPA values, which decrease significantly more than in glaucomatous eyes with IOP lowering. (p=0.04) Conclusion: IOP change has a more effect on OPA in normal than in glaucomatous eyes statistically.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To assess the affect of intraocular pressure (IOP) change on ocular pulse amplitude (OPA) in normal and glaucomatous eyes. Materials and Methods: IOP and OPA of 55 eyes with open angle glaucoma and 51 control eyes were recorded both before and after topical application of apraclonidin or dorzolamide so as to measure baseline and differential OPA in normal and glaucomatous eyes by using dynamic contour tonometers. Results: In glaucomatous and normal eyes, the mean measurement of IOP was 16.42±2.88 and 15.44±2.66 mmHg (p=0.07), the mean OPA measurement was 2.48±0.79 and 2.32±0.73 mmHg (p=0.48) respectively. After the topical antiglaucomatous drug application, IOP was 14.54±2.27 mmHg with a decrease of 10.70%±10.00 in glaucomatous eyes and 12.59±2.82 mmHg with a decrease of 16.10%±8.80 in normal eyes (p=0.01). With IOP change, OPA became 2.14±0.77 mmHg with a decrease of 13.96%±17.30 in glaucomatous eyes and 1.82±0.70 mmHg with a decrease of 19.90%±22.20 in normal eyes. Normal eyes had insignificantly lower OPA values, which decrease significantly more than in glaucomatous eyes with IOP lowering. (p=0.04) Conclusion: IOP change has a more effect on OPA in normal than in glaucomatous eyes statistically.

Özet

Amaç: Primer açık açılı glokom hastaları ile sağlıklı bireylerde göz içi basınç (GİB) değişikliğinin oküler nabız basıncı (ONB) üzerindeki etkisinin incelenmesi. Gereç ve Yöntem: Primer açık açılı glokomu olan 55 hasta ve 51 sağlıklı bireyin dinamik kontur tonometre (DKT) ile ölçülen bazal GİB ve ONB değerleri ve topikal aproklonidin veya dorzolamid uygulaması sonrasında elde edilen ONB değerleri kaydedildi. Bulgular: Glokom ve kontrol grubundaki ortalama GİB değerleri 16.42±2.88 ve 15.44±2.66 mmHg (p=0.07), ortalama ONB değerleri ise sırası ile 2.48±0.79 ve 2.32±0.73 mmHg (p=0.48) idi. Topikal antiglokomatöz uygulamasının ardından GİB değerleri glokom grubunda %10.70±10.00 azalarak ortalama 14.54±2.27 mmHg olurken, kontrol grubunda %16.10±8.80 azalarak ortalama 12.59±2.82 mmHg oldu. Kontrol grubunda saptanan yüzde değişim glokom grubundan anlamlı yüksekti (p=0.01). GİB'ındaki bu düşüş sonrası ONB'ı glokom grubunda %13.96±17.30 azalarak 2.14±0.77, kontrol grubunda %19.90±22.20 azalarak 1.82±0.70 mmHg oldu. Kontrol grubunda saptanan ONB yüzde değişimi glokom grubundan anlamlı yüksekti (p=0.04), (Tablo 2). Bununla birlikte GİB değişimi ile ONB değişimi arasında anlamlı bir korelasyon saptanamadı. Sonuç: Normal bireylerde GİB değişimi, ONB üzerinde glokomatöz hastalarda görülenden istatistiksel anlamlılıkta daha fazla bir etkiye sahiptir.

🔖

Cite This Article

CÖMERT, E., BEDEN, Ü., ÖZARSLAN, M., SÖNMEZ, B., ÖGE, İ., ERKAN, D. (2011). Affect of ıntraocular pressure change on ocular pulse amplitude in normal and glaucomatous eyes. Glokom Katarakt, Cilt: 6 - Sayı: 4, 230–234. https://ajindex.com/articles/226505

References (16)

  1. Allingham RR, Damji K, Freedman S, et al.: Clinical epidemiology of glaucoma. In: Shields’ Textbook of Glaucoma 5th ed. Philadelphia: Lippincott Williams and Wilkins. 2005:170-190
  2. Flammer J, Orgul S, Costa VP, et al.: The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359-393
  3. Trew DR, Smith SE.: Postural studies in pulsatile ocular blood flow: II. Chronic open angle glaucoma. Br J Ophthalmol. 1991;75:71-75
  4. Hoffmann EM, Grus FH, Pfeiffer N.: Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry. BMC Ophthalmol. 2004;4:4
  5. Langham ME, To’Mey KF.: A clinical procedure for the measurements of the ocular pulse pressure relationship and ophthalmic arterial pressure. Exp Eye Res. 1978;27:17-25
  6. Silver DM, Farrell RA.: Validity of pulsatile ocular blood flow measurements. Surv Ophthalmol. 1994;38:72-80
  7. Ehongo A, de Maertelaer V, Cullus P, et al.: Correlation between corneal hysteresis, corneal resistance factor, and ocular pulse amplitude in healty subjects. J Fr Ophthalmol. 2008;31:999-1005
  8. Perkins ES.: The ocular pulse. Curr Eye Res. 1981;1:19-23
  9. Silver DM, Geyer O.: Pressure volume relation for the living human eye. Curr Eye Res. 2000;20:115-120
  10. Schmidt KG, Rückmann Av, Pillunat LE. Topical carbonic anhydrase inhibition increases ocular pulse amplitude in high tension primary open angle glaucoma. Br J Ophthalmol. 1998; 82: 758-762
  11. Georgopoulos GT, Diestelhorst M, Fisher R, et al. The short-term effect of latanoprost on intraocular pressure and pulsatile ocular blood flow. Acta Ophthalmol. 2002;80:54-58
  12. Schmidt KG, Dick B, von Ruckmann A, et al. Ocular pulse amplitude and local carbonic anhydrase inhibition. Ophthalmologe. 1997;94:659-664
  13. Schmidt KG, von Ruckmann A, Becker R, et al.: Ocular pulse amplitude intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma. Klin Monatsbl Augenheilkd. 1999;215:361-366
  14. Fuchsjager-Mayrl G, Wally B, Rainer G, et al.: Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. Br J Ophthalmol. 2005;89:1293-1297
  15. Stalmans I, Haris A, Vanbellingen Wv, et al.: Ocular pulse amplitude in normal tension and primary open angle glaucoma. J Glaucoma. 2008;17:403-407
  16. Punjabi OS, Ho HK, Kniestedt C, et al.: Intraocular pressure and ocular pulse amplitude comparisons in differ