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Journals / Gülhane Tıp Dergisi / 2005 / Cilt: 47 - Sayı: 1

A case of syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxicity

Flekainide tedavisine bağlı hepatotoksisite ve kronik "pacing" eşiğinin yükselmesi sonucu senkop'la seyreden bir olgu

Basri AMASYALI
Sedat KÖSE
Sait DEMİRKOL
Hürkan KURŞAKLIOĞLU
Turgay ÇELİK
Ersoy IŞIK
Pages
73–76
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report a case presenting with syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxcitiy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:It is known that several pharmacologic agents have deleterious effect on pacing threshold.
📊
Key Findings & Data:Although pacemaker capture loss due to flecainide treatment, one of these pharmacologic agents, has been reported in the literature, in our best knowledge there are no reports of a case with concomitant hepatotoxicity.
💡
Conclusion & Impact:We report a case presenting with syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxcitiy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Senkop · Flekainid · Kalp pili

Abstract

It is known that several pharmacologic agents have deleterious effect on pacing threshold. Although pacemaker capture loss due to flecainide treatment, one of these pharmacologic agents, has been reported in the literature, in our best knowledge there are no reports of a case with concomitant hepatotoxicity. We report a case presenting with syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxcitiy.

Özet

Birçok farmakolojik ajanın, kalp pili eşik düzeylerini olumsuz yönde etkiledikleri bilinmektedir. Bu ajanlardan biri olan flecainide alımına bağlı kronik kalp pili eşik yükselmesi sonucu, kalp pili "capture" kaybı literatürde bildirilmiş olsa da, bildiğimiz kadarıyla hepatotoksisite'nin de eşlik ettiği bir olgu bildirilmiş değildir. Bu yazıda, flecainide kullanımına bağlı karaciğer toksisitesi ve kalıcı pili eşik yükselmesi sonrası, senkop gelişen idiyopatik hipertrofik subaortik stenozlu bir olgu sunulmaktadır.

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Cite This Article

AMASYALI, B., KÖSE, S., DEMİRKOL, S., KURŞAKLIOĞLU, H., ÇELİK, T., IŞIK, E. (2005). A case of syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxicity. Gülhane Tıp Dergisi, Cilt: 47 - Sayı: 1, 73–76. https://ajindex.com/articles/225679

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References (9)

  1. Huang, S.K., Hedberg, P.S., Marcus, F.I.: Effects of antiarrhythmic drugs on the chronic pacing threshold and the endocardial R wave amplitude in the conscious dog. Pacing Clin Electrophysiol 9:660-669, 1986
  2. Hellestrand, K.J., Nathan, A.W., Bexton, R.S., Camm, A.J.: Electrophysiologic effects of flecainide acetate on sinus node function, anomalous atrioventricular connections, and pacemaker thresholds.Am J Cardiol 53:30B- 38B, 1984
  3. Hellestrand, K,J., Burnett, P.J., Milne, J.R., Bexton, R.S., Nathan, A.W., Camm, A.J.: Effect of the antiarrhythmic agent flecainide acetate on acute and chronic pacing thresholds.Pacing Clin Electrophysiol 6:892-899, 1983
  4. Walker, P.R., Papouchado, M., James, M.A., Clarke, L.M.: Pacing failure due to flecainide acetate. Pacing Clin Electrophysiol 8:900-902, 1985
  5. Fornieles-Perez, H., Montoya-Garcia, M., Levine, P.A., Sanz, O.: Documentation of acute rise in ventricular capture thresholds associated with flecainide acetate. Pacing Clin Electrophysiol 25:871-872, 2002
  6. Antonelli, D., Freedberg, N.A., Rosenfeld, T.: Acute loss of capture due to flecainide acetate: Pacing Clin Electrophysiol 24:1170, 2001
  7. Estes, NAM3., Garan, H., Ruskin, J.N.: Electrophysiological properties of flecainide acetate: Am J Cardiol 53(Suppl): 26B-29B, 1984
  8. Hook, B.G., Perlman, R.L., Callans, D.J., Hanna, M.S., Kleiman, R.B., Flores, B.T., Marchlinski, F.E.: Acute and chronic cycle length dependent increase in ventricular pacing threshold. Pacing Clin Electrophysiol 15:1437-1444, 1992
  9. Lynch, M.J., Gerostamoulos, J.: Flecainide toxicity: cause and contribution to death. Legal Medicine 3:233-236, 2001.