Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2015 / Cilt: 12 - Sayı: 2

Evaluation Of The Retinal Nerve Fiber Layer And Macular Thickness In Patients With Transient Monocular Blindness

Geçici Görme Kaybı Olgularında Optik Koherens Tomografi İle Retina Sinir Lifi Ve Makülanın Değerlendirilmesi

Pages
269–273
Publication Date
2015-08-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies with larger sample size in which OCT findings of patients with TMB are evaluated would be beneficial to obtain detailed information.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Chronic cerebral hypoperfusion was observed in patients with transient ischemic attack.
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Key Findings & Data:Transient monocular blindness (TMB) accounts for 25% of transient ischemic attacks.
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Conclusion & Impact:Further studies with larger sample size in which OCT findings of patients with TMB are evaluated would be beneficial to obtain detailed information.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Geçici İskemik Atak · Geçici Görme Kaybı (Amarozis Fugaks) · Optik Koherens Tomografi

Abstract

Background: Chronic cerebral hypoperfusion was observed in patients with transient ischemic attack. In order to prevent a subsequent ischemic stroke, early diagnosis and proper management of transient ischemic attack are essential. Transient monocular blindness (TMB) accounts for 25% of transient ischemic attacks. Ischemic TMB occurs in the internal carotid territory and is a risk for ischemic stroke. Among patients with TMB, 27-67% of them had carotid artery stenosis and associated with a risk of ischemic stroke. Optical coherence tomography (OCT) which is widely used in ophthalmology is a noninvasive and easy technique that allows imaging of the retinal nerve fiber layer thickness (RNFT) and macular volume. In the present study, we aimed to evaluate the OCT findings of RNFT, central foveal thickness (CFT) and macular volume of patients with TMB. Methods: This is a prospective, comparative study of the 14 patients with TMB and 16 age and sex-matched healthy subjects. After routine eye examination; RNFT, macular volume and CFT measurements were performed by OCT. Results: There was no significant difference between two groups in respect of age and sex (p=0,60 and p=0,71 respectively). In our study group, the mean total RNFT was significantly higher in comparison to the control (p=0,008). In respect to sectoral evaluation, RNFT did not differ significantly between the study and 3 the control group (p>0,05). The mean macular volume was 8,6±0,2 mm in the control group and it was 3 9,0±0,6 mm in the study group and this was significantly higher (p<0,001). Similarly, the CFT was 264,2±32,9 μm in the control group and it was 309,2±64,9 μm in the study group and this was significantly higher (p<0,001). Conclusion: In the present study, the total RNFT, macular volume and CFT were found to be higher in patients with TMB compared to the controls. Further studies with larger sample size in which OCT findings of patients with TMB are evaluated would be beneficial to obtain detailed information.

Özet

Amaç: Geçici iskemik atak olgularında kronik serebral hipoperfüzyonu saptanmıştır. Takip edebilecek iskemik serebrovasküler hastalık gelişimini engellemek için geçici iskemik atağın erken tanısının konması ve gerekli müdahalenin yapılması önemlidir. Geçici görme kaybı (GGK) geçici iskemik atakların %25'ini oluşturmaktadır. İskemiye bağlı oluşan GGK de internal karotid arterin perfüzyon alanında olup serebral iskemi için risk oluşturmaktadır. Geçici görme kaybı hastalarının %27-67'sinde zeminde karotis arter hastalığı vardır ve iskemik serebrovasküler hastalık açısından önemli bir risk oluşturur. Optik koherens tomografi (OKT), oftalmolojide yaygın olarak kullanılan retina sinir lifi kalınlığı (RSLK) ve maküler hacmin ölçüldüğü noninvasif, kolay bir yöntemdir. Çalışmamızda GGK tanısı alan olguların OKT ile RSLK, santral foveal kalınlık ve maküla hacminin değerlendirimesi amaçlanmıştır. Materyal ve Metod: Prospektif olarak yapılan bu çalışmaya 14 GGK hastası ve kontrol grubu olarak 16 sağlıklı birey dahil edilmiştir. Her iki gruba da rutin oftalmolojik muayeneyi takiben OKT kullanılarak RSLK, maküla hacmi ve santral foveal kalınlık ölçümleri alınmıştır. Bulgular: Yaş ve cinsiyet açısından iki grup arasında istatistiksel açıdan anlamlı bir farklılık yoktu (sırasıyla p=0,60 ve p=0,71). Çalışma grubunda total RSLK, kontrol grubu ile karşılaştırıldığında anlamlı olarak daha fazla olduğu görüldü (p=0,008). Fakat sektörlere göre RSLK değerlendirildiğinde hiç bir sektör için iki grup 3 arasında anlamlı fark olmadığı görüldü (p>0,05). Kontrol grubunun ortalama maküla hacmi 8,6±0,2 mm 3 iken çalışma grubunda bu değer 9,0±0,6 mm idi (p<0,001). Ortalama santral foveal kalınlık kontrol grubunda 264,2±32,9 μm iken çalışma grubunda 309,2±64,9 μm idi (p<0,001). Sonuç: Bu çalışmada GGK hastalarında total RSLK, total maküla hacminin ve santral foveal kalınlığın anlamlı bir şekilde artmış olduğu izlenmiştir. Daha geniş hasta serilerinde GGK tanısı alan olguların OKTverilerinin değerlendirilmesi daha detaylı bilgi sağlayacaktır.

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Cite This Article

GÖNCÜ, T., OĞUZ, H., AKAL, A., ÇAKMAK, S., ADIBELLİ, F. M., KOCATÜRK, Ö. (2015). Evaluation Of The Retinal Nerve Fiber Layer And Macular Thickness In Patients With Transient Monocular Blindness. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 12 - Sayı: 2, 269–273. https://ajindex.com/articles/22521

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