Journals / Gülhane Tıp Dergisi / 2012 / Cilt: 54 - Sayı: 3

İntrakraniyal tümörlerde stereotaktik radyocerrahi: Tek merkez deneyimi

Stereotactic radiosurgery for intracranial tumors: A single center experience

Pages
190–198
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Stereotactic radiosurgery offers a safe and effective treatment approach for intracranial benign/malignant lesions and functional disorders leading to improved local control, survival and quality of life.

📌 3 Key Takeaways

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Objective & Hypothesis:Stereotactic radiosurgery is being increasingly used for the treatment of both benign and malignant disorders such as brain metastasis, spinal cord tumors, intracranial blood vessel abnormalities and neurological/functional problems such as Parkinson’s disease, epilepsy, obsessive-compulsive disorder and trigeminal neuralgia.
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Key Findings & Data:More than 400 treatments have been performed using stereotactic radiosurgery between 1998 and 2010 for intracranial benign and malignant lesions along with functional disorders.
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Conclusion & Impact:Stereotactic radiosurgery offers a safe and effective treatment approach for intracranial benign/malignant lesions and functional disorders leading to improved local control, survival and quality of life.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Geriyedönük çalışma · Beyin neoplazmları · Radyocerrahi

Abstract

Stereotactic radiosurgery is being increasingly used for the treatment of both benign and malignant disorders such as brain metastasis, spinal cord tumors, intracranial blood vessel abnormalities and neurological/functional problems such as Parkinson’s disease, epilepsy, obsessive-compulsive disorder and trigeminal neuralgia. The purpose of this report was to present our experience at the Department of Radiation Oncology of Gulhane Military Medical Faculty using linear accelerator-based stereotactic radiosurgery technology and to examine the efficacy and safety of radiosurgery in the treatment of the most common intracranial tumors and functional disorders. More than 400 treatments have been performed using stereotactic radiosurgery between 1998 and 2010 for intracranial benign and malignant lesions along with functional disorders. In this study, patients treated using stereotactic radiosurgery were retrospectively examined to determine the radiosurgical parameters, duration of follow-up, treatment response and patient survival. Functional, radiological and clinical improvement was achieved in most of the patients treated using stereotactic radiosurgery either by improving local control, providing decompression, obliteration of pathologic vessels, or preventing hemorrhages. Stereotactic radiosurgery offers a safe and effective treatment approach for intracranial benign/malignant lesions and functional disorders leading to improved local control, survival and quality of life.

Özet

Stereotaktik radyocerrahi beyin metastazı, spinal kord tümörleri, intrakraniyal damar anomalileri gibi benign ve malign bozukluklar ile Parkinson hastalığı, epilepsi, obsesif kompulsif bozukluk ve trigeminal nevralji gibi nörolojik/fonksiyonel problemlerin tedavisinde giderek artan sıklıkta kullanılmaktadır. Bu çalışmanın amacı Gülhane Askeri Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı’nın lineer akseleratör-tabanlı stereotaktik radyocerrahi teknolojisi ile olan deneyimlerini sunmak ve en sık görülen intrakraniyal tümör ve fonksiyonel bozuklukların tedavisinde radyocerrahinin etkinliğini ve güvenirliğini araştırmaktır. İntrakraniyal benign ve malign lezyonlar ile fonksiyonel bozukluklukların 1998 ile 2010 yılları arasındaki stereotaktik radyocerrahisinde 400’den fazla tedavi uygulanmıştır. Bu çalışmada radyocerrahiyle tedavi edilen hastalar radyocerrahi parametreleri, tedavi sonrası takip süresi, tedavi cevabı ve sağkalım açısından retrospektif olarak incelenmiştir. Sterotaktik radyocerrahi ile tedavi edilmiş hastaların çoğunda lokal kontrolün düzelmesi, dekompresyon sağlanması, patolojik damarların obliterasyonu ve kanamanın önlenmesi ile fonksiyonel, radyolojik ve klinik iyileşme sağlanmıştır. Stereotaktik radyocerrahi intrakraniyal benign/malign lezyonlar ile fonksiyonel bozuklukların lokal kontrolünü, hasta sağkalımını ve hasta yaşam kalitesini artıran güvenilir ve etkili bir tedavi yaklaşımıdır.

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Cite This Article

DİNÇOĞLAN, F., SAĞER, Ö., GAMSIZ, H., UYSAL, B., DEMİRAL, S., DİRİCAN, B., OYSUL, K., SÜRENKÖK, S., ŞİRİN, S., BEYZADEOĞLU, M. (2012). İntrakraniyal tümörlerde stereotaktik radyocerrahi: Tek merkez deneyimi. Gülhane Tıp Dergisi, Cilt: 54 - Sayı: 3, 190–198. https://ajindex.com/articles/224823

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References (17)

  1. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 1951; 102: 316-319
  2. Kirn TF. Proton radiotherapy: some perspectives. JAMA 1988; 259: 787-788
  3. Skarsgard LD. Radiobiology with heavy charged particles: a historical review. Phys Med 1998; 14 (Suppl 1): 1-19
  4. Betti O, Derechinsky V. Hyperselective encephalic irradiation with a linear accelerator. Acta Neurochir 1984; 33: 385-390
  5. Columbo F, Benedetti A, Pozza F, et al. External stereotactic irradiation by linear accelerator. Neurosurgery 1985; 16: 154-160
  6. Luxton G, Petrovich Z, Joszef G, Nedzi LA, Apuzzo ML. Stereotactic radiosurgery: principles and comparison of treatment methods. Neurosurgery 1993; 32: 241-259
  7. Adler JR Jr, Colombo F, Heilbrun MP, Winston K. Toward an expanded view of radiosurgery. Neurosurgery 2004; 55: 1374-1376
  8. Pollock BE, Lunsford LD. A call to defi ne stereotactic radiosurgery. Neurosurgery 2004; 55: 1371-373
  9. Jayarao M, Chin LS. Robotics and its applications in stereotactic radiosurgery. Neurosurg Focus 2007; 23 (6): E6
  10. Andrews DW, Bednarz G, Evans JJ, Downes B. A review of 3 current radiosurgery systems. Surg Neurol 2006; 66 (6): 559-564
  11. Hazard L, Wang B, Skidmore TB, et al. Conformity of LINAC-based stereotactic radiosurgery using dynamic conformal arcs and micro-multileaf collimator. Int J Radiat Oncol Biol Phys 2009; 73: 562-570
  12. Chen JC, Girvigian MR. Stereotactic radiosurgery: instrumentation and theoretical aspects - part 1. Perm J 2005; 9: 23-26
  13. Jensen RJ, Wendland MM, Chern S, Shrieve DC. Novalis intensity-modulated radiosurgery: Methods for pretreatment planning. Neurosurgery 2008; 62: A2-A9
  14. Amendola BE, Wolf AL, Coy SR, Amendola M, Bloch L. Gamma knife radiosurgery in the treatment of patients with single and multiple brain metastases from carcinoma of the breast. Cancer J 2000; 6: 88-92
  15. Gerosa M, Nicolato A, Foroni R, et al. Gamma knife radiosurgery for brain metastases: a primary therapeutic option. J Neurosurg 2002; 97 (5 Suppl): 515-524
  16. Gerosa M, Nicolato A, Foroni R, Tomazzoli L, Bricolo A. Analysis of long-term outcomes and prognostic factors in patients with non-small cell lung cancer brain metastases treated by gamma knife radiosurgery. J Neurosurg 2005; 102 (Suppl): 75-80
  17. Hasegawa T, Kondziolka D, Flickinger JC, Germanwala A, Lunsford LD. Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy? Neurosurgery 2003; 52: 1318-1326. 18