Journals / Astım Allerji İmmünoloji / 2009 / Cilt: 7 - Sayı: 1

Should thyroid function tests and thyroid autoantibodies be investigated in chronic urticaria?

Kronik ürtikerde tiroid fonksiyon testleri ve tiroid otoantikorları istenmeli mi?

Pages
39–43
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In our study as no significant difference was found in thyroid hormone levels and autoantibodies between the patient and control groups except FT3, we recommend the investigation of the levels of thyroid hormones and antibodies in chronic urticaria patients if they have a clinical finding of thyroid disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Drugs, foods, infections and internal organ diseases are some of the factors accused in etiopathogenesis of the chronic urticaria.
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Key Findings & Data:Frequency of autoimmune thyroid diseases has been reported to be increased in chronic urticaria.
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Conclusion & Impact:Conclusion: In our study as no significant difference was found in thyroid hormone levels and autoantibodies between the patient and control groups except FT3, we recommend the investigation of the levels of thyroid hormones and antibodies in chronic urticaria patients if they have a clinical finding of thyroid disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Drugs, foods, infections and internal organ diseases are some of the factors accused in etiopathogenesis of the chronic urticaria. In addition to this autoimmunity was considered to have a role in chronic urticaria. Frequency of autoimmune thyroid diseases has been reported to be increased in chronic urticaria. The aim of our study is to determine if there is an alteration in the levels of thyroid hormones and thyroid antibodies and if it is necessary to investigate them in chronic urticaria. Materials and Methods: Seventy seven patients with chronic urticaria and 71 healthy individuals as control group was included in the study. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), antithyroglobulin (AbTG), and antithyroidperoxidase antibody (AbT-PO) levels were measured in all of the subjects. Results: The levels of FT4, TSH and AbTPO and AbTG were not statistically different between two groups. The levels FT3 were found to be significantly increased in the patient group. No significant difference was found between the number of patients and controls who had abnormal levels of FT3, FT4, TSH, AbTPO, AbTG and AbTPO and/or AbTG levels. No correlation was found between the duration of disease and FT3, FT4, TSH, AbTPO and AbTG levels. Conclusion: In our study as no significant difference was found in thyroid hormone levels and autoantibodies between the patient and control groups except FT3, we recommend the investigation of the levels of thyroid hormones and antibodies in chronic urticaria patients if they have a clinical finding of thyroid disease.

Özet

Giriş: Kronik ürtiker etyopatogenezinde ilaçlar, yiyecekler, infeksiyonlar veya iç organ hastalıkları gibi çeşitli faktörler suçlanmaktadır. Ayrıca kronik ürtikerde otoimmünitenin rolü olduğu düşünülmektedir ve özellikle otoimmün tiroid hastalıklarının kronik ürtikerli hastalarda arttığı bildirilmektedir. Çalışmamızın amacı kronik ürtikerli hastalarda tiroid fonksiyon testleri ve tiroid antikorları düzeylerinde değişiklik olup olmadığını belirlemek ve bu tetkiklerin rutin olarak istenmesi gerekip gerekmediğini saptamaktır. Gereç ve Yöntem: Çalışmaya retrospektif olarak kronik ürtikerli 77 hasta ve kontrol grubu olarak 71 sağlıklı kişi alındı. Hasta ve kontrol grubunun serbest tiroksin (sT4), serbest triiodotironin (sT3), tiroid stimüle edici hormon (TSH), antitiroglobulin antikor (anti-TG) ve antitiroidperoksidaz antikor (anti-TPO) seviyeleri ölçüldü. Bulgular: Hasta ve kontrol grubu arasında sT4, TSH düzeyleri, anti-TPO ve anti-TG düzeyleri karşılaştırıldığında her iki grup arasında anlamlı farklılık saptanmadı. sT3 düzeyleri ise hasta grubunda anlamlı olarak yüksek bulundu. Ayrıca, hasta ve kontrol grupları arasında sT3, sT4, TSH, anti-TPO, anti-TG ve anti-TG ve/veya anti-TPO düzeyleri anormal olan kişilerin sayıları karşılaştırıldığında her iki grup arasında anlamlı farklılık saptanmadı. Hasta grubunda hastalık süresi ile sT3, sT4, TSH düzeyleri, anti-TPO ve anti-TG düzeyleri arasında anlamlı bir ilişki saptanmadı. Sonuç: Çalışmamızda tiroid hormonları ve otoantikor düzeylerinde sT3 düzeyi haricinde hasta ve kontrol grupları arasında anlamlı fark saptanmadı, bu nedenle kronik ürtikerli hastalarda ancak tiroid hastalığını düşündüren bulgular mevcutsa tiroid otoantikorları ve tiroid hormon düzeyleri bakılmasını önermekteyiz.

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Cite This Article

GÜL, Ü., ÇAKMAK, S., GÖNÜL, M., SOYLU, S., KILIÇ, A. (2009). Should thyroid function tests and thyroid autoantibodies be investigated in chronic urticaria?. Astım Allerji İmmünoloji, Cilt: 7 - Sayı: 1, 39–43. https://ajindex.com/articles/216224

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