SavedAdd your journal

Journals / Glokom Katarakt / 2013 / Cilt: 8 - Sayı: 3

Cyclosporine a, systemic and topical fresh-frozen plasma treatment of ligneous conjunctivitis

Odunsu konjonktivitte topikal siklosporin a, topikal ve sistemik taze donmuş plazma tedavisi

Zeynep ALKIN
NİHAT SAYIN
Abdullah ÖZKAYA
Ece KRANDİ UZUN
Ahmet Taylan YAZICI
Ahmet DEMİROK
Pages
199–204
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Topical 1% cyclosporin A, topical and systemic FFP therapies may be helpful to reduce the symptoms and to prevent the recurrences in cases with ligneous conjunctivitis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ligneous conjonctivitis is a rare disorder which is characterized by the formation of membranes on the palpebral conjunc- tiva.
📊
Key Findings & Data:We aimed to report three patients with ligneous conjonctivitis; a 5 year-old girl, and two sisters who are 19 and 23 years-old.
💡
Conclusion & Impact:Topical 1% cyclosporin A, topical and systemic FFP therapies may be helpful to reduce the symptoms and to prevent the recurrences in cases with ligneous conjunctivitis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Ligneous conjonctivitis is a rare disorder which is characterized by the formation of membranes on the palpebral conjunc- tiva. We aimed to report three patients with ligneous conjonctivitis; a 5 year-old girl, and two sisters who are 19 and 23 years-old. All the three patients were presented with complaints of discharge, redness and membranes on the lids. Both of the sisters had vascularized leukoma in their right eyes. Furthermore, the sisters had also hepatosplenomegaly and gingi- vitis. Clinical and symptomatic recovery, and a decrease in the formation of newly formed membranes were obtained with topical 1% cyclosporin, topical and systemic fresh frozen plasma (FFP) therapies in all the three cases; however, no regres- sion was observed in pre-existing membranes. Topical 1% cyclosporin A, topical and systemic FFP therapies may be helpful to reduce the symptoms and to prevent the recurrences in cases with ligneous conjunctivitis.

Özet

Odunsu konjonktivit nadir görülen; palpebral konjonktivada tekrarlayıcı membranlarla seyreden bir hastalıktır. Burada biri 5 yaşında ve diğer ikisi kardeş olan 19 ve 23 yaşlarında lignöz konjonktivitli üç bayan olguyu sunmayı amaçladık. Űç olgu da kliniğimize sulanma, kızarıklık ve kapaklarda zar oluşumu şikayetleri ile başvurdu. İki kız kardeşin sağ gözlerin- de kornea santralinde vaskülarize lökom mevcuttu. Bu iki olguda ayrıca hepatosplenomegali ve gingivit de vardı. Topikal %1’lik siklosporin, topikal ve sistemik taze donmuş plazma (TDP) tedavisi ile her üç olguda da klinik ve semptomatik iyileşme ile yeni zarların oluşumunda azalma olmasına karşın; mevcut olan zarlarda bir gerileme görülmedi. Topikal %1 siklosporin A, topikal ve sistemik TDP tedavileri membranların tekrarı ve semptomatik iyileşme sağlanmasında odunsu konjonktivit olgularında yardımcı olabilir.

🔖

Cite This Article

ALKIN, Z., SAYIN, N., ÖZKAYA, A., UZUN, E. K., YAZICI, A. T., DEMİROK, A. (2013). Cyclosporine a, systemic and topical fresh-frozen plasma treatment of ligneous conjunctivitis. Glokom Katarakt, Cilt: 8 - Sayı: 3, 199–204. https://ajindex.com/articles/213650

References (19)

  1. Schwarz GS, Holland EJ. Induction of ligneous conjunctivitis by conjunctival surgery. Am J Ophthalmol 1995;120:253-54
  2. Bierly JR, Blandford DL, Weeks JA et al. Ligneous conjunctivitis as a complication following strabismus surgery. J Pediatr Ophthalmol Strabismus 1994;31:99-103
  3. Verhoeff FH: A case of ligneous conjunctivitis Now 36 Years in Duration. Am J Ophthalmol 1958;45:246-51
  4. Winter FC and Michler RR. Chronic Membranous Conjunctivitis. AMA Arch Ophthalmol 1953;49:161-3
  5. Eagle RC, Brooks JS, Katowitz JA et al. Fibrin as a major constituent of ligneous conjunctivitis. Am J Ophthalmol.1986;101:493-4
  6. Cooper TJ, Kazdan JJ, Cutz E. Ligneous conjunctivitis with tracheal obstruction. A case report with light and electron microscopy findings. Can J Ophthalmol 1979;14:57-62
  7. De Cock R, Ficker LA, Dart JG et al. Topical heparin in the treatment of ligneous conjunctivitis. Ophthalmology 1995;102:1654-9
  8. Firat T. A new method fort he treatment of ligneous conjunctivitis. Turk J Pediatr 1969;11:31-7
  9. Francois J, Victoria-Troncoso V. Treatment of ligneous conjunctivitis. Am Ophthalmol 1968;65:674-8
  10. Klammt J, Kobelt L, Aktas D et al. Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity. Thromb Haemost. 2011;105:454-60
  11. Coskun M, Ayintap E, Keskin U ve ark. Lignöz konjonktivitte membran eksizyonu sonrası topikal siklosporin a kullanılan iki Olgu. T Klin Ophthalmol 2011;20:162-5
  12. Schott D, Dempfle CE, Beck P et al. Therapy with a purified plasminogen concantrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. N Engl J Med 1998;339:1679-86
  13. Rubin BI, Holland EJ, De Smet MD et al. Response of reactivated ligneous conjunctivitis to topical cyclosporine. Am J Ophthalmol 1991;112:95-6
  14. Holland EJ, Olsen TW, Ketcham JM et al. Topical cyclosporin A in the treatment of anterior segment inflamatory disease. Cornea 1993;12:413-9
  15. Borel MG. Un nouveau syndrome palpebral. Bull Soc Fr Ophthalmol 1933;46:168-180
  16. Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol 2003;48:369- 88
  17. Gokbuget AY, Mutlu S, Scully C et al. Amyloidaceous ulcerated gingival hyperplasia: a newly described entity related to ligneous conjunctivitis. J Oral Pathol Med 1997;26:100-4
  18. David G. Heidemenn, MD, George A. Et al. Treatment of ligneous conjunctivitis with topical plazmin and topical plazminogen. Cornea 2003;22:760-2
  19. Caputo R, Pu