Transient pseudothrombocytopenia in a neonate with congenital rubella infection

In case of low platelet counts in newborns, using EDTA as an anticoagulant, PTCP should always be excluded even when thrombocytopenia is explicable as in this case of congenital rubella infection to avoid unnecessary interventions.

📌 3 Key Takeaways

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Objective & Hypothesis:A newborn with congenital rubella infection and transient pseudothrombocytopenia (PTCP), an association which has not been reported before, is described.

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Key Findings & Data:Laboratory investigations revealed a thrombocyte count of 67,000/mm3 in EDTA anticoagulated blood, antirubella IgM positivity, normal coagulation tests.

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Conclusion & Impact:In case of low platelet counts in newborns, using EDTA as an anticoagulant, PTCP should always be excluded even when thrombocytopenia is explicable as in this case of congenital rubella infection to avoid unnecessary interventions.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Süt çocuğu · yenidoğan · Kızamıkçık

Abstract

A newborn with congenital rubella infection and transient pseudothrombocytopenia (PTCP), an association which has not been reported before, is described. The patient was a term neonate with petechia on the face, cardiac systolic murmur and splenomegaly. Laboratory investigations revealed a thrombocyte count of 67,000/mm3 in EDTA anticoagulated blood, antirubella IgM positivity, normal coagulation tests. Echocardiography revealed atrial septal defect, patent ductus arteriosus, mitral insufficiency, brain magnetic resonance imaging showed periventricular hyperintense nodular areas. A repeated thrombocyte count in EDTA-anticoagulated blood was 28,000/ mm3, simultaneous blood smear showed multiple platelet clumps with an estimated number greater than 100,000/mm3. Repeated counts showed the same discrepancy leading to a diagnosis of PTCP. When the baby was 2 months of age platelet counts with automatic analyzers normalized showing that PTCP was transient. In case of low platelet counts in newborns, using EDTA as an anticoagulant, PTCP should always be excluded even when thrombocytopenia is explicable as in this case of congenital rubella infection to avoid unnecessary interventions.

Özet

Bu yazıda daha önce bildirilmeyen bir ilişki olarak konjenital rubella infeksiyonu ile birlikte geçici psödotrombositopenisi (PTCP) olan bir yenidoğan sunulmuştur. Yüzde peteşi, kalpte sistolik üfürüm ve splenomegali ile başvuran term bebeğin laboratuvar incelemelerinde EDTA'lı alınan kan örneğindeki trombosit sayısı 67,000Ğmm3, antirubella IgM pozitif bulundu, pıhtılaşma testleri normaldi. Ekokardiyografide ASD, PDA ve mitral yetmezlik, beyin manyetik rezonans görüntülemede periventriküler hiperintens nodüler bölgeler saptandı. Tekrarlanan kan sayımında EDTA'lı alınan örnekte trombosit sayısı 28,000Ğmm3 iken, aynı anda yapılan periferik yaymada çok sayıda trombosit kümeleri görüldü ve trombosit sayısı >100,000Ğmm3 olarak bildirildi. Tekrarlanan sayımlarda da benzer uyumsuzluk devam ettiğinden psödotrombositopeni olarak değerlendirildi. Bebek 2 aylık olduğunda otomatik kan sayımı ile trombosit sayıları normale döndü, bu da PTCP'nin geçici olduğunu gösterdi. Yenidoğanlarda EDTA'lı kan örneklerinde trombosit sayısı düşük saptandığında, bu vakada olduğu gibi trombositopeniyi açıklayacak bir neden olsa bile, PTCP mutlaka dışlanarak gereksiz incelemeler önlenmelidir.

Keywords

Süt çocuğu yenidoğan Kızamıkçık Trombositopeni Infant Newborn Rubella Thrombocytopenia

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Cite This Article

İNCE, Z., SAĞLAM, A., KARAKAŞ, Z., ÇOBAN, E. A., PALABIYIK, M., CAN, G. (2006). Transient pseudothrombocytopenia in a neonate with congenital rubella infection. Çocuk Dergisi, Cilt: 6 - Sayı: 2, 140–142. https://ajindex.com/articles/213501

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