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Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2002 / Cilt: 7 - Sayı: 3

The evaluation of the antituberculous drug resistance rates of Mycobacterium tuberculosis strains by BACTEC 460 TB system

Mycobacterium tuberculosis suşlarında antitüberküloz ilaç direnç oranlarının BACTEC 460 TB kültür sistemi ile değerlendirilmesi

Özgül KISA
Ali ALBAY
ORHAN BAYLAN
Levent DOĞANCI
Pages
171–176
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Continuons monitoring of drug resistance in M. tuberculosis is essential in order to support national tuberculosis control programs although our resistance rates are below the dangerous zone.

📌 3 Key Takeaways

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Objective & Hypothesis:We retrospectively evaluated the specimens sent to Microbiology and Clinical Microbiology Laboratory between January 1998 and April 2001 to detect the susceptibility rates of Mycobacterium tuberculosis strains to four primary antituberculous drugs.
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Key Findings & Data:Drug susceptibility tests to isoniazid (INH), streptomycin (S), ethambutol (E), and rifampin (R) were performed by using the radiometric BACTEC 460 TB system.
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Conclusion & Impact:Continuons monitoring of drug resistance in M. tuberculosis is essential in order to support national tuberculosis control programs although our resistance rates are below the dangerous zone.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Mycobacterium tuberculosis · İlaç direnci · bakteriyel

Abstract

We retrospectively evaluated the specimens sent to Microbiology and Clinical Microbiology Laboratory between January 1998 and April 2001 to detect the susceptibility rates of Mycobacterium tuberculosis strains to four primary antituberculous drugs. Drug susceptibility tests to isoniazid (INH), streptomycin (S), ethambutol (E), and rifampin (R) were performed by using the radiometric BACTEC 460 TB system. From 390 patients, 886 isolates evaluated and multiple isolates from a single source were agreed as one strain, and 85.6% of isolates were susceptible to all four major drugs, whereas 14.4% were resistant to at least one. Mono resistance rate was 10.3% and two strains (0.5%) were resistant to all four drugs. Multidrug resistance (MDR) was found in 1.0% of the isolates while polyresistance rate other than MDR was observed in 12 (3.1 %) isolates. Continuons monitoring of drug resistance in M. tuberculosis is essential in order to support national tuberculosis control programs although our resistance rates are below the dangerous zone.

Özet

Mycobacterium tuberculosis'm dört primer antitüberküloz ilaç için duyarlılığını saptamak amacıyla, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı Mikobakteriyoloji Laboratuvan'na Ocak 1998-Nisan 2001 tarihleri arasında gönderilen örnekler retrospektif olarak değerlendirildi, izoniazid (INH), streptomisin (S), etambutol (E) ve rifampine (R) duyarlılık testleri, BACTEC 460 TB kültür sistemi ile gerçekleştirildi. M. tuberculosis pozitif olarak bulunan 390 hastaya ait 886 izolatın, her hasta için tek bir suşu değerlendirmeye alındı. İzolatların %85.6'sı dört ilaca birden duyarlı bulunurken; %14.4'ü en az bir ilaca dirençliydi. Sadece tek bir ilaca dirençlilik oranı %I0.3, dört ilacın hepsine birden dirençlilik oranı ise %0.5 olarak bulundu. Çok ilaca direnç (MDR) İzolatların %1.0'inde, MDR hariç çok ilaca direnç ise %3.1'inde gözlendi. Bizim sonuçlarımıza göre; merkezimizde M. tuberculosis'm ilaç direnci tehlike sınırlarının altındadır. Ancak direnç oranlarının sürekli izlenmesi, ulusal tüberküloz kontrol programını desteklemek amacıyla gereklidir.

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Cite This Article

KISA, Ö., ALBAY, A., BAYLAN, O., DOĞANCI, L. (2002). The evaluation of the antituberculous drug resistance rates of Mycobacterium tuberculosis strains by BACTEC 460 TB system. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 7 - Sayı: 3, 171–176. https://ajindex.com/articles/213100

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