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Journals / Çocuk Dergisi / 2006 / Cilt: 6 - Sayı: 3

Evaluation of thyroid hormone levels in preterm newborns

Preterm bebeklerde tiroid fonksiyonları

Öznur KILIÇ
Ayça VİTRİNEL
Serdar CÖMERT
Feza AKSOY
YASEMİN AKIN
Pages
161–166
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thyroid hormone therapy may have an important effect to decrease morbidity and mortality in newborns, but larges studies are needed to verify this issue.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate thyroid functions in preterm babies and to compare their values with healthy preterm and term newborns.
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Key Findings & Data:Methods: Within a one year period, from April 2003 to April 2004, 23 healthy term, 12 healthy preterm and 18 sick preterm babies were included in our study.
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Conclusion & Impact:Thyroid hormone therapy may have an important effect to decrease morbidity and mortality in newborns, but larges studies are needed to verify this issue.
🔬Design:Research Article
📍Scope:2003 Verileri
⚙️Variables:Süt çocuğu · prematür · Tiroid hormonları

Abstract

Aim: To evaluate thyroid functions in preterm babies and to compare their values with healthy preterm and term newborns. Methods: Within a one year period, from April 2003 to April 2004, 23 healthy term, 12 healthy preterm and 18 sick preterm babies were included in our study. First, 5th and 10th day blood samples were collected in order to determine TT3 (total T3), TT4(total T4), FT3(free T3), FT4(free T4) ve TSH (thyroid stimulating hormone) levels. Results: In healthy newborns, with decreasing gestational age and birth weight TT3, TT4, FT3, FT4 levels decreased. Preterm babies did not experience the physiological changes in thyroid hormones as term babies did. The thyroid hormone levels of sick preterms were found to be statistically lower. But no statistical significant difference was found between healthy and sick preterms. Regarding TSH levels no difference was found between healthy term, healthy and sick preterm newborns. Conclusion: Significant hypothroxinemia observed in preterm newborns may suggest thyroid hormone replacement therapy. Thyroid hormone therapy may have an important effect to decrease morbidity and mortality in newborns, but larges studies are needed to verify this issue.

Özet

Amaç: Preterm bebeklerdeki tiroid fonksiyonlarını incelemek, hasta ve sağlıklı pretermler ile zamanında doğan sağlıklı bebeklerin düzeylerini karşılaştırmak. Yöntem: Nisan 2003-Nisan 2004 tarihleri arasında hastanemiz yenidoğan servisine muayene için gönderilen 23 term sağlıklı, 12 preterm sağlıklı ve 18 preterm hasta bebek çalışmaya dahil edildi. Çalışmaya alınan tüm vakalardan 1. gün (0-24 saat), 5. gün ve 10. gün venöz kanları alınarak TT3 (total T3), TT4 (total T4), FT3 (serbest T3), FT4 (serbest T4) ve TSH (tiroid stimulan hormon) değerleri çalışıldı. Bulgular: Sağlıklı bebeklerde gestasyon yaşı ve doğum ağırlığı azaldıkça TT3, TT4, FT3, FT4 düzeylerinin azaldığı, term bebeklerde meydana gelen fizyolojik değişikliklerin pretermlerde meydana gelmediğini ve hasta pretermlerde term bebeklere göre TT3, TT4, FT3, FT4 düzeylerinin anlamlı düşük olduğu saptandı. Sağlıklı preterm ve hasta pretermler arasında tiroid hormon düzeyleri açısından istatistiksel bir farklılık yoktu. TSH düzeyi açısından sağlıklı preterm, hasta preterm ve term bebekler arasında istatistiksel farklılık saptanmadı. Sonuç: Pretermlerde belirgin hipotiroksinemi saptanmakta ve bu durum tiroid hormon tedavisini akla getirmektedir. Tiroid hormon tedavisinin bebeklerde mortalite ve morbiditenin azaltılmasında önemli etkileri olabileceği düşünülebilirse de bunun için daha geniş çaplı yeni çalışmalara gereksinim duyulmaktadır.

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Cite This Article

KILIÇ, Ö., VİTRİNEL, A., CÖMERT, S., AKSOY, F., AKIN, Y. (2006). Evaluation of thyroid hormone levels in preterm newborns. Çocuk Dergisi, Cilt: 6 - Sayı: 3, 161–166. https://ajindex.com/articles/212368

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