SavedAdd your journal

Journals / Glokom Katarakt / 2015 / Cilt: 10 - Sayı: 1

Evaluation of Retinal Nerve Fiber Layer and Central Corneal Thickness Measurements in Patients with Obstructive Sleep Apnea Syndrome

Obstrüktif Uyku Apne Sendromlu Olgularda Retina Sinir Lifi Analizi ve Santral Korneal Kalınlık Parametrelerinin Değerlendirilmesi

Emine Esra KARACA
ZEYNEP AKTAŞ
Feyzahan EKİCİ
CELAL MURAT HASANREİSOĞLU
Şengül ÖZDEK
Tansu ULUKAVAK ÇİFTÇİ
Pages
37–40
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PSG parameters including the mean saturation of oxygen, lowest saturation of oxygen and AHI severity did not correlate with RNFL thickness and CCT.Conclusion: In the current study, there was no significant correlation between clinical diagnosis of glaucoma and OSAS.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: To evaluate retinal nerve fiber layer (RNFL) and central corneal thickness (CCT) in patients with obstructive sleep apnea syndrome (OSAS).Materials and Methods: Patients presenting with snoring and daytime sleepiness who applied to Sleep Unit of Pulmonary Diseases underwent overnight polysomnography (PSG).
📊
Key Findings & Data:The patients with OSAS were referred for ophthalmologic examination. 45 patients with OSAS (Group 1) and 38 normal control subjects (Group 2) were included in the study.
💡
Conclusion & Impact:PSG parameters including the mean saturation of oxygen, lowest saturation of oxygen and AHI severity did not correlate with RNFL thickness and CCT.Conclusion: In the current study, there was no significant correlation between clinical diagnosis of glaucoma and OSAS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To evaluate retinal nerve fiber layer (RNFL) and central corneal thickness (CCT) in patients with obstructive sleep apnea syndrome (OSAS).Materials and Methods: Patients presenting with snoring and daytime sleepiness who applied to Sleep Unit of Pulmonary Diseases underwent overnight polysomnography (PSG). The patients with OSAS were referred for ophthalmologic examination. 45 patients with OSAS (Group 1) and 38 normal control subjects (Group 2) were included in the study. CCT and RNFL thickness by Heidelberg Retinal Tomograph were measured besides the routine ophthalmologic examination.Results: The right eyes of patients were included in both groups. Average RNFL thicknesses were was 96.8±8.3 µm in OSAS group and 99.4±8.4 µm in control group and this difference was statistically significant (p=0.03). Superior and nasal RNFL thickness in Group 1 were significantly lower than Group 2 (respectively; p=0.02, p=0.01). No significant difference was detected in CCT between groups (p=0.21). Average cup/disc ratios were 0.23±0.08 (0.2-0.7) and 0.21±0.07 (0.2-0.4) in OSAS and control groups, respectively (p=0.04). PSG parameters including the mean saturation of oxygen, lowest saturation of oxygen and AHI severity did not correlate with RNFL thickness and CCT.Conclusion: In the current study, there was no significant correlation between clinical diagnosis of glaucoma and OSAS.

Özet

Amaç: Obstrüktif uyku apne sendrom (OSAS)'lu olgularda retina sinir lifi tabakası (RNFL) kalınlığının ve santral kornea kalınlığının (SKK) değerlendirilmesi.Gereç ve Yöntem: Horlama ve gündüz aşırı uyku hali ile göğüs hastalıkları uyku merkezi polikliniğine başvuran hastalara gece polisomnografi (PSG) testi uygulandı. PSG uygulanan ve OSAS tanısı konulan hastalara oftalmolojik muayene yapıldı. Çalışmaya 45 OSAS'lı (Grup 1), 38 kontrol (Grup 2) olgusu dahil edildi. Tüm hastaların rutin göz muayenelerinin yanında SKK ve Heidelberg Retina Tomografisi ile RNFL kalınlığı ölçümü yapıldı.Bulgular: Her iki gruptaki olguların sağ gözleri çalışmaya dahil edildi. Ortalama RNFL kalınlığı OSAS grubunda 96.8±8.3 µm, kontrol grubunda 99.4±8.4 µm idi ve bu fark istatistiksel olarak anlamlıydı (p=0.03). RNFL kalınlığı Grup 1'de, superior ve nazal kadranlarda Grup 2'ye göre anlamlı düzeyde düşük bulundu (sırasıyla; p=0.02, p=0.01). Grup 1'de SKK grup 2'ye göre inceydi ancak bu fark anlamlı değildi (p=0.21). Ortalama cup/disk oranları OSAS ve kontrol grubunda sırasıyla 0.23±0.08 (0.2-0.7) ve 0.21±0.07 (0.2-0.4) idi (p=0.04). PSG sırasında elde elden ortalama oksijen saturasyonu (mSO2), en düşük oksijen saturasyonu (LSAT) ve AHI şiddeti ile RNFL ve SKK arasında herhangi anlamlı bir ilişki saptanmadı.Sonuç: Bu çalışmada klinik glokom tanısı ile OSAS arasında anlamlı ilişki bulunmamıştır.

🔖

Cite This Article

KARACA, E. E., AKTAŞ, Z., EKİCİ, F., HASANREİSOĞLU, C. M., ÖZDEK, Ş., ÇİFTÇİ, T. U. (2015). Evaluation of Retinal Nerve Fiber Layer and Central Corneal Thickness Measurements in Patients with Obstructive Sleep Apnea Syndrome. Glokom Katarakt, Cilt: 10 - Sayı: 1, 37–40. https://ajindex.com/articles/200396

References (15)

  1. Lin PW, Friedman M, Lin HC, et al. Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea/hypopnea syndro- me. Graefes Arch Clin Exp Ophthalmol 2011;249:585-93.
  2. Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120:714-20. 3. Leske MC, Heijl A, Hyman L, et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 2007;114:1965-72.
  3. Chervin RD, Guilleminault C. Obstructive sleep apnea and related di- sorders. Neurol Clin 1996;14:583-609.
  4. Geyer MJ, Brienza DM, Bertocci GE, et al. Wheelchair seating: a state of the science report. Assist Technol. Winter 2003;15:120-8. 6. Mojon DS, Hess CW, Goldblum D, et al. High prevalence of glaucoma in patients with sleep apnea syndrome. Ophthalmology 1999;106:1009-12.
  5. Bendel RE, Kaplan J, Heckman M, et al. Prevalence of glaucoma in patients with obstructive sleep apnoea--a cross-sectional case-series. Eye (Lond) 2008;22:1105-9.
  6. Sergi M, Salerno DE, Rizzi M, et al. Prevalence of normal tension glaucoma in obstructive sleep apnea syndrome patients. J Glaucoma 2007;16:42-6.
  7. Mojon DS, Hess CW, Goldblum D, et al. Primary open-angle gla- ucoma is associated with sleep apnea syndrome. Ophthalmologica 2000;214:115-8.
  8. Mojon DS, Hess CW, Goldblum D, et al. Normal-tension glaucoma is as- sociated with sleep apnea syndrome. Ophthalmologica 2002;216:180-4.
  9. Kargi SH, Altin R, Koksal M, et al. Retinal nerve fibre layer measure- ments are reduced in patients with obstructive sleep apnoea syndrome. Eye (Lond) 2005;19:575-9.
  10. Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell at- rophy correlated with automated perimetry in human eyes with glau- coma. Am J Ophthalmol 1989;107:453-64.
  11. Mojon DS, Mathis J, Zulauf M, et al. Optic neuropathy associated with sleep apnea syndrome. Ophthalmology 1998;105:874-7.
  12. Quigley HA, Addicks EM. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve dama- ge. Arch Ophthalmol 1981;99:137-43.
  13. Kato M, Roberts-Thomson P, Phillips BG, et al. Impairment of endot- helium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000;102:2607-10.
  14. Narkiewicz K, Montano N, Cogliati C, et al. Altered cardiovascular va- riability in obstructive sleep apnea. Circulation 1998;98:1071-7.
  15. Hayreh SS, Zimmerman MB, Podhajsky P, et al. Noct