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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2021 / Cilt: 45 - Sayı: 2

PHARMACOKINETIC EVALUATION OF DRUG-DRUG INTERACTIONS IN THE TREATMENT OF COVID-19

COVID-19 TEDAVİSİNDE İLAÇ-İLAÇ ETKİLEŞİMLERİNİN FARMAKOKİNETİK AÇIDAN DEĞERLENDİRİLMESİ

Nuran COŞKUN
Ozge ULKER
Pages
443–456
Publication Date
2021-05-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the report published by the Ministry of Health Coronavirus Research Advisory Board on the diagnosis, treatment and control of COVID-19, drug combination therapy (hydroxychloroquine, lopinavir / ritonavir and favipiravir) is recommended by health

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The COVID-19 pandemic, which started in Wuhan, China and affected the whole world, still represents a unique global challenge with its contagiousness and lethality.
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Key Findings & Data:The symptoms of COVID-19 patients may differ depending on the severity of the disease.
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Conclusion & Impact:According to the report published by the Ministry of Health Coronavirus Research Advisory Board on the diagnosis, treatment and control of COVID-19, drug combination therapy (hydroxychloroquine, lopinavir / ritonavir and favipiravir) is recommended by health
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:COVID-19 · drug-drug interactions · pharmacokinetic

Abstract

Objective: The COVID-19 pandemic, which started in Wuhan, China and affected the whole world, still represents a unique global challenge with its contagiousness and lethality. The symptoms of COVID-19 patients may differ depending on the severity of the disease. According to the report published by the Ministry of Health Coronavirus Research Advisory Board on the diagnosis, treatment and control of COVID-19, drug combination therapy (hydroxychloroquine, lopinavir / ritonavir and favipiravir) is recommended by health

Özet

Amaç: Çin'in Wuhan kentinde başlayan ve tüm dünyayı etkileyen COVID-19 pandemisi, bulaşıcılığı ve ölümcüllüğü benzersiz bir küresel mücadeleyi hala temsil etmektedir. COVID-19 hastalarının semptomları, hastalığın ciddiyetine göre farklılık gösterebilmektedir. Sağlık Bakanlığı Koronavirüs Araştırma Danışma Kurulu, COVID-19'un teşhisi, tedavisi ve kontrolü hakkında yayınladığı rapora göre ilaç kombinasyon tedavisi (hidroksiklorokin, lopinavir / ritonavir ve favipiravir) sağlık yetkilileri tarafından önerilmektedir. Çoğunlukla karaciğerde bulunan sitokrom P 450 enzimleri (CYP) tarafından metabolize edilen bu ilaçların diğer bazı ilaçlarla eş zamanlı kullanımları sonucu ilaç-ilaç etkileşimi olası bir durumdur. Biz bu derlemede COVID-19 tedavisinde kullanılan ilaçların özellikle metabolizma yolaklarını da belirterek farmakokinetik olarak ilaç-ilaç etkileşmelerini göstermeyi amaçladık.

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Cite This Article

COŞKUN, N., ULKER, O. (2021). PHARMACOKINETIC EVALUATION OF DRUG-DRUG INTERACTIONS IN THE TREATMENT OF COVID-19. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 - Sayı: 2, 443–456. https://ajindex.com/articles/198828

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