Journals / Çocuk Dergisi / 2003 / Cilt: 3 - Sayı: 2

Evaluation of recurrens risk in the wheezy infants

Hışıltı atağı geçiren çocuklarda rekürrens riskinin incelenmesi

Pages
139–143
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

It is concluded that these parameters have predictive value about wheezing recurrence and developing asthma.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It has been reported that majority of infants with wheezing attacks with no spesific diagnosis have permanent disease forever.
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Key Findings & Data:Method: A total of 40 patients with the complaints of coug-hing, wheezing and dyspnea and 18 healthy subjects were studied.
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Conclusion & Impact:It is concluded that these parameters have predictive value about wheezing recurrence and developing asthma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Astım · Kan hücresi sayımı · İmmünoglobulin E

Abstract

Aim: It has been reported that majority of infants with wheezing attacks with no spesific diagnosis have permanent disease forever. The aim of this study is to investigate blood eosinophil count, serum total IgE, serum eosinophilic cationic protein (ECP), RSV IgM and IgG levels in infants with recurrent wheezing attacks. Method: A total of 40 patients with the complaints of coug-hing, wheezing and dyspnea and 18 healthy subjects were studied. The patients were divided in to high risk and low risk groups consisting of 22 and 18 patients respectively. Results: In patients with high risk for developing asthma, mean serum ECP level was significantly different from the level of the patients with low risk and that of the control group (p=0.01 andp=0.035, respectively). There were statistically difference between serum IgE levels and blood eosinophil counts of high and low risk groups (P<0.01). Conclusion: As a result the infants with history and clinical findings of recurrent wheezing have higher levels of ECP, eosinophil count and serum total IgE. It is concluded that these parameters have predictive value about wheezing recurrence and developing asthma.

Özet

Amaç: Sütçocukluğu döneminde hışıltı atağı geçiren ve spesifik tanı almamış çocukların büyük bölümünde bu atakların kalıcı hal aldığı bildirilmektedir. Bu çalışmada hışıltı atağı nedeniyle hastaneye başvuran 0-2 yaş grubu çocuklar kişisel, ailesel hikayeleri ve klinik durumlarına göre atopi yönünden risk gruplarına ayrılarak, serum total IgE, periferik kan eozinofil sayımı, serum eozinofilik katyonikprotein (ECP), RSVIgM ve IgG parametrelerinin incelenmesi amaçlanmıştır. Yöntem: Çalışmaya öksürük, hışıltı ve solunum sıkıntısı nedeniyle hastaneye yatırılan 40 hasta ve 18 sağlıklı çocuk kontrol grubu olarak alındı. Hasta grupları 22 kişilik yüksek risk ve 18 kişilik düşük risk olmak üzere iki gruba Bulgular: Astım gelişimi açısından yüksek riskli grupta serum ECP düzeyleri düşük risk grubu ve kontrol grubuna oranla anlamlı olarak yüksek bulundu (Sırasıyla, p= 0.01, p=0.035). Hasta grupları arasında serum IgE düzeyleri ve periferik kan eozinofil sayıları açısından da istatistiksel olarak anlamlı fark vardı (p<0.01). Sonuç: Sonuç olarak tekrarlayan hışıltı atağı ve atopi öyküsü olan çocuklarda serum ECP, serum total IgE ve kan eozinofil düzeyleri yüksek bulunmuştur. Bu parametrelerin tekrarlayan hışıltı ve astım gelişme riski açısından prediktif değeri olduğu düşünülmektedir.

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Cite This Article

ÜNAY, B., ÇETİNAY, S., KISMET, E., AKIN, R., GÖKÇAY, E. (2003). Evaluation of recurrens risk in the wheezy infants. Çocuk Dergisi, Cilt: 3 - Sayı: 2, 139–143. https://ajindex.com/articles/197308

References (19)

  1. Bierman CW. Allergy, Asthma and Immunology from Infancy to Adulthood. Third ed. Philadelphia: WB Saunders Company, 1996
  2. Gergen PJ, Weiss KB. Changing patterns of asthma hospitalization among children 1979 to 1987. JAMA 1990; 264: 1688-90
  3. Martinez FD, Wright AL, Taussig LM. Asthma and wheezing in the first six year of life. N Engl J Med 1995; 332: 133-8
  4. Morgan WJ, Martinez FD. Risk factors for developing wheezing and asthma in childhood. Pediatr Clin North Am 1992; 39: 1185-97
  5. Zimmerman B, Enander I, Zimmerman R, Ahlstedt S. Asthma in children less than five years of age: eosinophils and serum levels of eosinophil proteins ECP and EPX in relation to atopy and symtoms. Clin Exp Allergy 1994; 24: 149-55
  6. Demir E. Hışıltılı bebekte prognoz
  7. Ulusal Çocuk Solunum Yolu Hastalıkları Kongresi, 10-12 Mayıs 2002, Kongre Özet Kitabı, s:46-7
  8. Martinez FD. Recognizing early asthma. Allergy 1999; 54(Suppl 49): 24-8
  9. Yazıcıoğlu M. Astımda erken tanı yöntemleri
  10. Ulusal Çocuk Solunum Yolu Hastahklan Kongresi, 10-12 Mayıs 2002, Kongre Özet Kitabı, s:53-4
  11. Martinez FD. Present and future treatment of asthma in infants and young children. J Allergy Clin Immunol 1999; 104: 169-74
  12. Klinnert MD, Nelson HS, Price MP, Adinoff AD, Leung DYM, Mrazek DA. Onset and persistence of childhood asthma: Predictors from infancy. Pediatrics 2001; 108: E69
  13. Sly RM. Asthma. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. Philadelphia: WB Saunders Co, 2000: 1274-8
  14. Venge P, Dahl D, Fredens K, HaUgreen R, Peterson C. Eosinophil cationic proteins ECP and EPX in health and disease. In: Yoshida T, Torisu M, eds. Immunobiology of the Eosinophil. Newyork: Elsevier, 1983: 163-79
  15. Koller DY, Herovy Y, Götz M, Hagel E, Urbanek R, Eichler I. Clinical value of monitoring Eosinophil activity in childhood asthma. Arch Dis Child 1995; 73: 413-7
  16. Roller DY, Wojnarowski C, Herkner KR, et al. High levels of eosinophil cationic protein in wheezing infant predict the devel-opment of asthma. J Allergy Clin Immunol 1997; 99: 752-6
  17. Ingram JM, Rakes GP, Hoover GE, et al. Eosinophil cationic protein in serum and in nasal washes from wheezing infants and children. J Pediatr 1995; 127: 558-64
  18. Welliver RC, Wong DT, Sun M, et al. The development of respiratory syncytial virus-spesific IgE and the release of hista-mine in nasopharyngeal secretion after infection. N Engl J Med 1981; 305: 841-6
  19. American Academy of Pediatrics. Re