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Journals / Çocuk Acil ve Yoğun Bakım Dergisi / 2017 / Cilt: 4 - Sayı: 1

Kaspofunginle Antifungal Kilit Tekniği Başarısızlık Nedenleri: Daha Yüksek Konsantrasyon İhtiyacı

Reasons for Failure of Antifungal-lock Therapy with Caspofungin: Need for Higher Concentrations

Rana İŞGÜDER
Gökhan CEYLAN
Özlem SANDAL
Ferhat SARI
Gamze GÜLFİDAN
Bengü DEMİRAĞ
HASAN AĞIN
İlker DEVRİM
Pages
30–32
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For now, we recommend higher doses of caspofungin for AfLT especially in Candida parapsilosis-related catheter infections.

📌 3 Key Takeaways

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Objective & Hypothesis:Antifungal-lock therapy (AfLT) has arrived as an investigational approach for preventing catheter removal with limited clinical evidence of its efficiency.
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Key Findings & Data:The principle of AfLT consists of catheter lumen replenishment by a selected antimicrobial agent and then locking it for an alternative treatment to eradicate the microbes embedded in endoluminal biofilms.
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Conclusion & Impact:For now, we recommend higher doses of caspofungin for AfLT especially in Candida parapsilosis-related catheter infections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Antifungal-lock therapy (AfLT) has arrived as an investigational approach for preventing catheter removal with limited clinical evidence of its efficiency. The principle of AfLT consists of catheter lumen replenishment by a selected antimicrobial agent and then locking it for an alternative treatment to eradicate the microbes embedded in endoluminal biofilms. Herein, we report a pediatric hematology-oncology patient with Candida parapsilosis-related central venous access device infection in which catheter removal was performed despite the systemic and intraluminal caspofungin treatment. For now, we recommend higher doses of caspofungin for AfLT especially in Candida parapsilosis-related catheter infections.

Özet

Antifungal kilit tekniği (AfKT) kateter çıkarılmasını engellemek amacı ile etkinliği hakkında kısıtlı verinin olduğu bir deneysel yaklaşım olarak karşımıza çıkmaktadır. Bu teknikte endoluminal biyofilmler içine gömülü olan etkenlerin eradike edilmesi için katater lümeni, seçilen antimikrobiyal ajanla doldurularak kapatılır. Burada yoğun bakım servisimizde yatan ve Candida parapsilosis ilişkili santral venöz kateter enfeksiyonu olan bir hematoloji-onkoloji hastasından gerek intraluminal gerekse sistemik kaspofungin tedavisine rağmen kateteri çıkartmak zorunda kalışımızı raporladık. Özellikle Candida parapsilosis ilişkili kateter enfeksiyonlarının AfKT ile tedavi edilebilmesi için daha yüksek dozda kaspofungin kullanılmasını önermekteyiz.

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Cite This Article

İŞGÜDER, R., CEYLAN, G., SANDAL, Ö., SARI, F., GÜLFİDAN, G., DEMİRAĞ, B., AĞIN, H., DEVRİM, İ. (2017). Kaspofunginle Antifungal Kilit Tekniği Başarısızlık Nedenleri: Daha Yüksek Konsantrasyon İhtiyacı. Çocuk Acil ve Yoğun Bakım Dergisi, Cilt: 4 - Sayı: 1, 30–32. https://ajindex.com/articles/197297

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