Insulin and cortisol levels in hypoglycemic newborn infants

Objective & Hypothesis:Aim: To assess insulin and cortisol levels in term small for gestational age, term appropriate for gestational age and preterm appropriate for gestational age hypoglycemic babies and estimate fetal and maternal risk factors associated with the development of hypoglycemia.

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Key Findings & Data:Material and Methods: Fourty-six hypoglycemic babies, who had serum glucose levels below 40 mg/dl (2.2 mmol/L) were included in the study.

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Conclusion & Impact:Conclusion: Insulin and cortisol, response in newborn infants were strongly associated with prematurity.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Süt çocuğu · prematür · Doğum ağırlığı

Abstract

Aim: To assess insulin and cortisol levels in term small for gestational age, term appropriate for gestational age and preterm appropriate for gestational age hypoglycemic babies and estimate fetal and maternal risk factors associated with the development of hypoglycemia. Material and Methods: Fourty-six hypoglycemic babies, who had serum glucose levels below 40 mg/dl (2.2 mmol/L) were included in the study. Twenty-six cases were appropriate for gestational age (group 1), ten cases were small for gestational age (group 2), ten cases were preterm (group 3). Infants with severe disease or acidosis were excluded. Results: There were no significant differences between the groups in the distribution of maternal and neonatal factors which could lead to hypoglycemia. Insulin levels were significantly different between group 1 and group 3 (p<0.01), cortisol levels were significantly different between group 2 and group 3 (p<0.05). Conclusion: Insulin and cortisol, response in newborn infants were strongly associated with prematurity.

Özet

Amaç: Hipoglisemik miyadında uygun doğum ağırlıklı (mAGA), miyadında düşük doğum ağırlıklı (mSGA) ve preterm uygun doğum ağırlıklı (pAGA) bebeklerde insülin-kortizol düzeyleri ve hipoglisemiye yol açabilecek maternal ve yenidoğana bağlı faktörlerin sıklığını belirlemek. Gereç ve Yöntem: Çalışmaya kan glukoz seviyesi 40 mg/dL (2.2 mmol/L)'nin altında tesbit edilen 46 hipoglisemik bebek alındı. Bebeklerden 26'sı mAGA (1. grup), 10'u mSGA (2. grup), 10'u pAGA (3. grup) idi. Ciddi hastalık ya da asidozu olan bebekler çalışmaya alınmadı. Bulgular: Gruplar arasında hipoglisemiye yol açabilecek anneye ve bebeğe bağlı faktörlerin dağılımında anlamlı bir farklılık bulunmadı. İnsülin seviyeleri açısından miyadında uygun doğum ağırlıklı grup (1. grup) ile preterm uygun doğum ağırlıklı grup (3. grup) arasında anlamlı farklılık gözlendi (p<0.01). Kortizol seviyeleri açısından ise miyadında düşük doğum ağırlıklı grup (2. grup) ile preterm uygun doğum ağırlıklı grup (3. grup) arasında anlamlı farklılık gözlendi (p<0.05). Sonuç: İnsülin ve kortizol yanıtı açısından prematüreliğin önemli bir faktör olduğu sonucuna varıldı.

Keywords

Süt çocuğu prematür Doğum ağırlığı Hidrokortizon Hipoglisemi yenidoğan İnsülin Infant Premature Birth Weight Hydrocortisone Hypoglycemia Newborn Insulin

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Cite This Article

OKAN, A. M., ÖZKAYA, E., YİĞİT, Ö., METE, F. M., SAMANCI, N., PURİSA, S. (2004). Insulin and cortisol levels in hypoglycemic newborn infants. Çocuk Dergisi, Cilt: 4 - Sayı: 3, 163–167. https://ajindex.com/articles/196024

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