SavedAdd your journal

Journals / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 5

Preparation and Potentiometric Study of Promethazine Hydrochloride Selective Electrodes and Their Use in Determining Some Drugs

Nabil S. NASSORY
Shahbaz A. Maki And Bashaer A. AL-PHALAHY
Shahbaz A. MAKI
Pages
539–548
Publication Date
2008-05-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The pH and life time of the electrodes were also studied.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Promethazine hydrochloride selective electrodes were constructed based on promethazine-phosphotun- gstic acid ion pair in PVC matrix membrane.
📊
Key Findings & Data:The electrodes based on DBP, TBP, and ONPOE gave the same linear range between 1 x 10-4 and 1 x 10-1 M, while the one based on DBPH ranged between 5 x 10-4 and 1 x 10-1M.
💡
Conclusion & Impact:The pH and life time of the electrodes were also studied.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Promathazine-HCl selective electrodes · phosphotungstic acid · promethazine determination

Abstract

Promethazine hydrochloride selective electrodes were constructed based on promethazine-phosphotun- gstic acid ion pair in PVC matrix membrane. The plasticizers used were di-butyl phosphate (DBP), tri-n-butyl phosphate (TBP), o-nitro phenyl octyl ether (ONPOE), and di-n-butyl phthalate (DBPH). The electrodes based on DBP, TBP, and ONPOE gave the same linear range between 1 x 10-4 and 1 x 10-1 M, while the one based on DBPH ranged between 5 x 10-4 and 1 x 10-1M. The slopes for linear range ranged from 40 to 56 mV/decade with correlation coefficients lying between 0.9984 and 0.9993. The best detection limit was 2 x 10-5M for the electrode based on DBPH. The standard deviation of potential drift ranged from \pm1 to \pm9 mV. The measurement interferences in the presence of Li+, Na+, K+, Mg2+, Ca2+, Zn2+, Fe3+, Cr3+, and Al3+ were studied using separate and match methods for selectivity coefficient determination. The pH and life time of the electrodes were also studied.

Özet

Promethazine hydrochloride selective electrodes were constructed based on promethazine-phosphotun- gstic acid ion pair in PVC matrix membrane. The plasticizers used were di-butyl phosphate (DBP), tri-n-butyl phosphate (TBP), o-nitro phenyl octyl ether (ONPOE), and di-n-butyl phthalate (DBPH). The electrodes based on DBP, TBP, and ONPOE gave the same linear range between 1 x 10-4 and 1 x 10-1 M, while the one based on DBPH ranged between 5 x 10-4 and 1 x 10-1M. The slopes for linear range ranged from 40 to 56 mV/decade with correlation coefficients lying between 0.9984 and 0.9993. The best detection limit was 2 x 10-5M for the electrode based on DBPH. The standard deviation of potential drift ranged from \pm1 to \pm9 mV. The measurement interferences in the presence of Li+, Na+, K+, Mg2+, Ca2+, Zn2+, Fe3+, Cr3+, and Al3+ were studied using separate and match methods for selectivity coefficient determination. The pH and life time of the electrodes were also studied.

🔖

Cite This Article

NASSORY, N. S., AL-PHALAHY, S. A. M. A. B. A., MAKI, S. A. (2008). Preparation and Potentiometric Study of Promethazine Hydrochloride Selective Electrodes and Their Use in Determining Some Drugs. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 5, 539–548. https://ajindex.com/articles/185008

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. British Pharmacopoeia on CD-ROM, Version 4, Copyright by Crown LTD, London, 94 (2000).
  2. M. Devani, B. Suhagia and S. Shah, Indian J. of Pharmaceutical Sciences, 61, 110-112 (1999).
  3. V. Ramakrishna, K. Basavaiah, H.C. Prameela and G.P. Nage, J. of Science, 36, 159-166 (2004).
  4. F.J. Lara, A.M. Garcia-Campana, F. Ales-Barrero and J.M. Bosque-Sendra, Analytica. Chimica. Acta,, 101-108 (2005).
  5. R. Bhushan and D. Gupta, Biomed. Chromatogr. 19, 474-478 (2005).
  6. N.S. Nassory, A.M.A. Al-Haidari and I.K.M. Al-Mashhadany, Chem. Anal. (Warsaw) 52, 55-64 (2007).
  7. N.S. Nassory, S.A. Maki and M.A. Ali, Turk. J. Chem. 31, 75-82 (2007).
  8. Z.S. Yang, J. Zhao, D.P. Zhang and Y.C. Lue, Anal. Sci. 23, 569-572 (2007).
  9. Y.M. Issa, N.T. Abdel-Ghani, A.F. Shoukry and H.W. Ahmed. Anal. Sci. 21, 1037-1042 (2005).
  10. A. Craggs, G.J. Moody and J.D.R. Thomas, J. Chem. Edu., 51, 541-544 (1974).
  11. Y. Umezaw, P. Buhlmann, K. Umezawa, K. Tohda and S. Amemiya, Pure Appl. Chem. 72, 1851-2082 (2000).
  12. K. Tohda, D. Dragoe, M. Shibata and Y. Umezawa, Anal. Sci. 17, 733-742 (2001). E. Alun, ”Potentiometry and Ion Selective Electrode” John Wiley and Sons Inc, New York, 1987.