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Journals / Turkish Journal of Chemistry / 2007 / Cilt: 31 - Sayı: 1

Preparation and Characterization of an Atenolol Selective Electrode Based on a PVC Matrix Membrane

Nabil S. NASSORY
Shahbaz A. Maki And Mutaz A. ALI
Mutaz A. ALI
Pages
75–82
Publication Date
2007-01-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The experimental results showed that the best electrode was based on DOPH as plasticizer, displaying a linear range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope of 55.91 mV/decade and correlation coefficient of 0.9995.

📌 3 Key Takeaways

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Objective & Hypothesis:Atenolol selective electrodes were prepared based on a complex atenolol-phosphotungstate as an active material using the plasticizers di-butyl phosphate (DBP), tri-butyl phosphate (TBP), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH) in a PVC matrix membrane.
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Key Findings & Data:The experimental results showed that the best electrode was based on DOPH as plasticizer, displaying a linear range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope of 55.91 mV/decade and correlation coefficient of 0.9995.
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Conclusion & Impact:The average recovery for atenolol determination in tablets was around 98.50%, with standard deviation \pm 0.1.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Atenolol selective electrode · atenolol determination · phosphotungstic acid

Abstract

Atenolol selective electrodes were prepared based on a complex atenolol-phosphotungstate as an active material using the plasticizers di-butyl phosphate (DBP), tri-butyl phosphate (TBP), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH) in a PVC matrix membrane. The properties of the prepared electrodes were studied, namely slope, concentration range, detection limit, lifetime, pH effect and selectivity. The experimental results showed that the best electrode was based on DOPH as plasticizer, displaying a linear range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope of 55.91 mV/decade and correlation coefficient of 0.9995. The detection limit was 5.00 x 10-5 M and the lifetime was around 90 days. The proposed electrode was successfully applied to the determination of atenolol in a pharmaceutical preparation. The average recovery for atenolol determination in tablets was around 98.50%, with standard deviation \pm 0.1.

Özet

Atenolol selective electrodes were prepared based on a complex atenolol-phosphotungstate as an active material using the plasticizers di-butyl phosphate (DBP), tri-butyl phosphate (TBP), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH) in a PVC matrix membrane. The properties of the prepared electrodes were studied, namely slope, concentration range, detection limit, lifetime, pH effect and selectivity. The experimental results showed that the best electrode was based on DOPH as plasticizer, displaying a linear range from 1.00 x 10-4 M to 5.00 x 10-2 M with a Nernstian slope of 55.91 mV/decade and correlation coefficient of 0.9995. The detection limit was 5.00 x 10-5 M and the lifetime was around 90 days. The proposed electrode was successfully applied to the determination of atenolol in a pharmaceutical preparation. The average recovery for atenolol determination in tablets was around 98.50%, with standard deviation \pm 0.1.

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Cite This Article

NASSORY, N. S., ALI, S. A. M. A. M. A., ALI, M. A. (2007). Preparation and Characterization of an Atenolol Selective Electrode Based on a PVC Matrix Membrane. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 1, 75–82. https://ajindex.com/articles/217992

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References (15)

  1. The pharmaceutical codex, ”Principle and Practical of Pharmaceutics” 21sted., The Pharmaceutical Press,
  2. London (1994). A.S. Alwan and Y.Z. Abou, “Iraqi Drugs Guide” 1sted., Iraq (1990).
  3. Y.G. Yee, P. Rubin and T.F. Blaschke, J. Chromatogr. A 171, 357-362 (1979).
  4. I. Rapado-Martinez, M.C. Garcia-Alvarez-Coque and R.M. Villanueva-Camonas, Analyst 121, 1677-1682 (1996).
  5. M. Sundaresan, S. Patil, I.C. Bhoir and Y.P. Patel, J. Chromatogr. A 828, 283-286 (1998).
  6. A.P. Argekar and J.G. Sawant, J. Liq. Chromatogr. 12, 202-206 (1999).
  7. P. Umapathi, I nt. J. Pharm. 108, 11-19 (1994).
  8. R.I. Stefan, G.E. Baiulescu and H.Y. Aboul-Enein, Trends Anal. Chem. 27, 307 (1997).
  9. H.Y. Aboul-Enein and X.X. Sun, Analusis 28, 855-858 (2000).
  10. H.Y. Aboul-Enien, X.X. Sun and C.J. Sun, Sensor 2, 424-431 (2002).
  11. N. Alizadeh and R. Mehdipour, J. Pharmaceut. Biomed. 30, 725-731 (2002).
  12. G.J. Moody, R.B. Oke and J.D.R. Thomas, Analyst 95, 910-918 (1970).
  13. J.E.W. Davis, G.J. Moody, W.M. Price and J.D.R. Thomas, Lab. Practice. 22, 20 (1973).
  14. Y. Umezawa, K. Umezawa and H. Sato, Pure Appl. Chem. 67, 507-518 (1995).
  15. Y. Umezawa, P. Buhlmann, K. Umezawa, K. Tohda and S. Amemiya, Pure and Appl. Chem. 72, 1851-2082 (2000).