Journals / Astım Allerji İmmünoloji / 2010 / Cilt: 8 - Sayı: 1

Autoimmune thyroiditis detected during allergen-specific immunotherapy: A case report

Allerjen spesifik immünoterapi sırasında saptanan otoimmün tiroidit: Bir olgu sunumu

Pages
59–63
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A 14-year-old girl diagnosed with asthma who developed findings of autoimmune thyroiditis and goiter four months after SIT with grass pollen antigens is presented to emphasize the possibility of autoimmune disease development during the course of SIT and the need for further research about this coexistence.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Allergen-specific immunotherapy (SIT) is a treatment modality that has been shown to be effective in the treatment of asthma, allergic rhinitis or anaphylaxis due to pollen, mite or venom hypersensitivity.
📊
Key Findings & Data:Clinical and immunologic advantages of a successful immunotherapy continue for years after the treatment is finished.
💡
Conclusion & Impact:A 14-year-old girl diagnosed with asthma who developed findings of autoimmune thyroiditis and goiter four months after SIT with grass pollen antigens is presented to emphasize the possibility of autoimmune disease development during the course of SIT and the need for further research about this coexistence.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Allergen-specific immunotherapy (SIT) is a treatment modality that has been shown to be effective in the treatment of asthma, allergic rhinitis or anaphylaxis due to pollen, mite or venom hypersensitivity. Clinical and immunologic advantages of a successful immunotherapy continue for years after the treatment is finished. Local and systemic side effects have been reported to be associated with SIT, but long-term side effects have not yet been clarified. The term autoimmune thyroiditis includes many different diseases. Impairment of cellular immunity due to genetic defect of suppressor T-cells lies beneath Hashimoto thyroiditis. A 14-year-old girl diagnosed with asthma who developed findings of autoimmune thyroiditis and goiter four months after SIT with grass pollen antigens is presented to emphasize the possibility of autoimmune disease development during the course of SIT and the need for further research about this coexistence.

Özet

Allerjen spesifik sistemik immünoterapi (SİT) polenlere, ev tozu akarlarına ve venomlara karşı aşırı duyarlılık sonucunda ortaya çıkan astım, allerjik rinit veya anafilaksi tedavisinde etkili olduğu gösterilmiş bir tedavi şeklidir. Başarılı bir immünoterapi tedavisinin klinik ve immünolojik faydaları tedavi sonlandırıldıktan yıllar sonra da devam eder. SİT’e bağlı kısa süre içinde ortaya çıkabilen lokal ve sistemik yan etkiler rapor edilmiştir, ancak uzun süreli yan etkileri henüz iyi bilinmemektedir. Otoimmün tiroidit, birbirileriyle ilişkileri henüz çok iyi anlaşılamamış pek çok farklı hastalığı içerir. Hashimoto tiroiditinde süpresör T hücrelerindeki genetik defekt sonucunda hücresel immünitenin bozulması söz konusudur. Astım tanısı alan 14 yaşındaki kız olgu, çimen polenleri ile SİT’e başlandıktan dört ay sonra otoimmün tiroidit ve guatr bulguları ortaya çıkmış olması nedeniyle SİT sürecinde otoimmün hastalıkların gelişebileceğinin ve ileri çalışmalarda bu birlikteliğin araştırılmasının vurgulanması amacıyla sunulmuştur.

🔖

Cite This Article

TÜRKELİ, A., YILMAZ, Ö., GÜLER, S., YÜKSEL, H. (2010). Autoimmune thyroiditis detected during allergen-specific immunotherapy: A case report. Astım Allerji İmmünoloji, Cilt: 8 - Sayı: 1, 59–63. https://ajindex.com/articles/165068

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;24:445-54
  2. Zeyrek FY, Zeyrek C. Allerjik hastalıklar ve parazitoz. Türkiye Parazitoloji Dergisi 2006;30:135-40
  3. Cox L. Allergen immunotherapy. A practice parameter second update. J Allergy Clin Immunol 2007;120: 25-85
  4. Yüksel H. Spesifik allerjen immünoterapide endikasyonlar ve kontrendikasyonlar. T Klin J Int Med Sci 2007;3:20-3
  5. Harmancı E. Allerjik rinit tedavisinde spesifik immünoterapi. T Klin J Allergy-Asthma 2002;4:81-5
  6. Bektaş A, Kınıklı G. Allerjen spesifik immünoterapi. T Klin Tıp Bilimleri 1993;13:46-9
  7. Nelson HS. Immunotherapy for inhalant allergens. In: Adkinson NF, Bochner BS, Busse WW, Holgate ST, Lemanske RFJ, Simons FER (eds). Middleton’s Allergy: Principles and Practice. 7th ed. Philadelphia: Elsevier, 2008:1657-78
  8. Turkcapar N, Kınıklı G, Dizbay S, Sak MD. Specific immunotherapy induced Sjogren’s syndrome. Rheumatol Int 2005;26:182-4
  9. Gönç EN. Otoimmün tiroidit. Otoimmünite. Katkı Dergisi 2002;23:358-63
  10. Wing K, Sakaguchi S. Allerjide potansiyel immünoterapi için regülatör T hücreler. Curr Opin Allergy Clin Immunol Turkish Edition 2006;1:4
  11. Canıtez Y, Öztürk RC, Sapan N. Alerjen spesifik immünoterapide lokal ve sistemik reaksiyonlar. Güncel Pediatri 2007;5:92-5
  12. Nakajimaa H, Ohtsuka H, Nishina T, Suginoa M, Kimuraa F, Hanafusaa T, et al. Multiple sclerosis after allergen-specific immunotherapy and influenza vaccination. Eur Neurol 2003;50:248-9
  13. Akdiş CA, Blaser K. IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: Two key steps in specific immunotherapy. T Klin J Allergy-Asthma 2000;2:42-4
  14. Larche M. Regulatory T cells in allergy and asthma. Chest 2007;132:1007-14
  15. Rook GAW, Adams V, Hunt J, Palmer RR, Martinelli R, Brunet R. Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Semin Immun 2004;25:237-55
  16. Morfín Maciel BM, Castillo Morfín BM. Scleroderma related to specific immunotherapy. A report of a case. Rev Alerg Mex 2009;56:136-45
  17. Joint Task Force on Practice Parameters from the American Academy of Allergy, Asthma and Immunology. Allergen immunotherapy: a practice parameter second update. J Allergy Clin Immunol 2007;120:25-85
  18. Kılıçturgay K. Aşırı duyarlık (hipersensitivite). İmmünoloji. Yenileştirilmiş 3. Baskı. İstanbul: Nobel & Güneş Kitabevi, 2003
  19. Dallas JS, Foley TP. Hyperthyroi