Journals / Epilepsi / 2003 / Cilt: 9 - Sayı: 1

Interaction of carbamazepine with clarithromycin: Increased blood carbamazepine levels in two patients

Karbamazepin ile klaritromisin etkileşimi: İki olguda karbamazepin kan düzeyinde yükselme

Journal
Epilepsi
Pages
34–37
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The presenting symptoms were attributed to Carbamazepine intoxication.

📌 3 Key Takeaways

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Objective & Hypothesis:A fifty-year-old man and a 71 -year-old woman had been on Carbamazepine treatment when they began to receive Clarithromycin for sinusitis and lower respiratory tract infection, respectively.
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Key Findings & Data:Increased blood carbamazepine levels were detected.
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Conclusion & Impact:The presenting symptoms were attributed to Carbamazepine intoxication.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İlaç tedavisi · kombinasyon · Karbamazepin

Abstract

A fifty-year-old man and a 71 -year-old woman had been on Carbamazepine treatment when they began to receive Clarithromycin for sinusitis and lower respiratory tract infection, respectively. One week after, the man complained of vertigo, dizziness, blurred vision, double vision, and slurred speech, and the woman of vertigo and blurred vision. Nystagmus was detected in both patients, whereas vestibular f unction tests and cranial magnetic resonance imaging showed no abnormal signs. Increased blood carbamazepine levels were detected. The complaints completely disappeared two days after lowering the Carbamazepine dosage in the male patient, and after lower dosages of the two drugs were used in the female patient. The presenting symptoms were attributed to Carbamazepine intoxication.

Özet

Elli yaşındaki erkek hasta sinüzit, 71 yaşındaki kadın hasta alt solunum yolu enfeksiyonu tanısı ile klaritromisin kullanmaya başlamıştı. Her iki olgu da karbamazepin tedavisi görmekteydi. Bir hafta sonra erkek olguda vertigo, dengesizlik, görmede ve konuşmada bozulma yakınmaları gelişti; aynı süre içinde kadın hastada da vertigo ve görme bozukluğu gözlendi. İki olgunun nörolojik muayenesinde nistagmuslar gözlenirken vestibüler fonksiyon testleri ve kraniyal manyetik rezonans görüntülemede anormal bulguya rastlanmadı. İki olguda da kandaki karbamazepin düzeyi artmış bulundu. İlk olgu karbamazepin dozunun azaltımı sonrasında, ikinci olgu her iki ilaç dozunun azaltımı sonrasında iki günde iyileşti. Ortaya çıkan semptomlar karbama-zepin entoksikasyonuna bağlandı.

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Cite This Article

KIYLIOĞLU, N., AKYOL, A., BÖLÜKBAŞI, O., KAYA, E. (2003). Interaction of carbamazepine with clarithromycin: Increased blood carbamazepine levels in two patients. Epilepsi, Cilt: 9 - Sayı: 1, 34–37. https://ajindex.com/articles/164502