AI Summary & Key Takeaways
AI InsightThe incidence of cardiotoxic effects depends on thedose and route of application.In this case report, a coronary vasospasm mimicking anterolateral myocardial infarction due to 5-fl uorouracil-induced cardiotoxicity was presented.It must be kept in mind that 5-fl uorouracil may cause coronary vasospasm mimicking acute myocardial infarction and the situation can be treated successfully with nitrates and calcium channelblockers.
📌 3 Key Takeaways
Abstract
5-Fluorouracil is the key chemotherapeutic agent used in the treatment of adenocarcinomas of the gastrointestinal system. However, serious cardiac side effects related to 5-fluorouracil treatment including coronary vasospasm, thrombosis, myocardial infarction, cardiomyopathy and sudden death have been reported previously. The incidence of cardiotoxic effects depends on thedose and route of application.In this case report, a coronary vasospasm mimicking anterolateral myocardial infarction due to 5-fl uorouracil-induced cardiotoxicity was presented.It must be kept in mind that 5-fl uorouracil may cause coronary vasospasm mimicking acute myocardial infarction and the situation can be treated successfully with nitrates and calcium channelblockers.
Özet
5-Fluorouracil gastrointestinal sistem adenokarsinomlarının tedavisinde anahtar kemoterapotik ajandır. Bu ajanın, koroner vazospazm, tromboz, miyokard infarktüsü, kardiyomyopati ve ani ölümgibi ciddi kardiyak yan etkileri bildirilmiștir. Kardiyotoksik etki görülme sıklığı doz ve veriliș yoluna göre değișmektedir.Burada 5-fluorouracil kardiyotoksisitesinin neden olduğu anterolateral miyokard infarktüsünü taklit eden bir koroner vazospazm olgusu sunulmuștur. 5-Fluorouracil uygulamasının akut miyokard infaktüsünü taklit eden koroner vazospazma neden olabileceği ve bu durumun nitrat ve kalsiyum kanal blokerleri ile bașarıyla tedavi edilebileceği akılda tutulmalıdır.