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Journals / Kafkas Journal of Medical Sciences / 2026 / Cilt: 16 Sayı: 2

Esophagogastric Junction Morphology is Associated with Ambulatory Reflux Monitoring Phenotypes in Patients Evaluated for Gastroesophageal Reflux Disease

Ali Karataş(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Özgür Çetinkaya(Department of Internal Medicine, Faculty of Medicine, Kafkas University, Kars, Türkiye)
Mehmet Cindoruk(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Tarkan Karakan(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Murat Kekilli(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Çağdaş Kalkan(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Beril Demir(Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara)
Pages
239–245
Publication Date
2026-08-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

EGJ morphology may complement, but should not replace, ambulatory reflux testing.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To evaluate whether high-resolution manometry-defined esophagogastric junction (EGJ) morphology is associated with objective reflux burden in adults evaluated for suspected gastroesophageal reflux disease.
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Key Findings & Data:Materials and Methods: Consecutive adults evaluated between January 2021 and December 2025 were retrospectively screened.
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Conclusion & Impact:EGJ morphology may complement, but should not replace, ambulatory reflux testing.
🔬Design:Modeling & Simulation
📍Scope:2021 Verileri
⚙️Variables:gastroesophageal reflux disease · esophagogastric junction · high-resolution manometry

Abstract

Aim: To evaluate whether high-resolution manometry-defined esophagogastric junction (EGJ) morphology is associated with objective reflux burden in adults evaluated for suspected gastroesophageal reflux disease. Materials and Methods: Consecutive adults evaluated between January 2021 and December 2025 were retrospectively screened. After exclusions, 243 patients who completed 36-channel high-resolution manometry and off-proton-pump-inhibitor pH-metry were included. Abnormal acid exposure time (AET) was defined as AET >6%. Associations were assessed using non-parametric tests and logistic regression adjusted for age, sex, hiatal hernia size, and lower esophageal sphincter pressure. Results: Mean age was 42.0 years and 146 patients (60.1%) were male. EGJ morphology was Type I in 111 patients, Type II in 81, and Type III in 51. Abnormal AET occurred in 38.7%, 22.2%, and 78.4% of Types I, II, and III, respectively (p<0.001). Median AET was 3.66%, 3.75%, and 10.79% (p<0.001). In the extended model, Type III remained associated with abnormal AET compared with Type I (OR 5.08, 95% CI 1.21-21.24; p=0.026). Conclusion: Type III EGJ morphology was associated with higher objective reflux burden, whereas Type II showed a heterogeneous pattern. EGJ morphology may complement, but should not replace, ambulatory reflux testing.

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Cite This Article

Karataş, A., Çetinkaya, Ö., Cindoruk, M., Karakan, T., Kekilli, M., Kalkan, Ç., Demir, B. (2026). Esophagogastric Junction Morphology is Associated with Ambulatory Reflux Monitoring Phenotypes in Patients Evaluated for Gastroesophageal Reflux Disease. Kafkas Journal of Medical Sciences, Cilt: 16 Sayı: 2, 239–245. https://ajindex.com/articles/1631476

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