Journals / Istanbul Kent University Journal of Health Sciences / 2026 / Cilt: 4 Sayı: 1

A case of Gastrointestinal Stromal Tumor Intestinal Fistula causing intestinal obstruction

İntestinal obstrüksiyon yapmış Tümör Bağırsak Fistülü olan Gastrintestinal Stromal Tümör olgusu

Acar Aren(ISTANBUL KENT UNIVERSITY)0000-0001-6797-3657
Esra Paşaoğlu(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL BAĞCILAR HEALTH RESEARCH CENTER)0000-0001-8967-9061
Aytül Hande Yardımcı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-5163-9141
Mert Mahsuni Sevinç(Sağlık Bilimleri Üniversitesi İstanbul Eğitim ve Araştırma hastanesi)0000-0002-5073-9714
Pages
20–24
Publication Date
2025-03-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In our case, it was determined that tumor bowel fistulization developed spontaneously even though it did not receive treatment, which is much rarer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Intestinal fistulization into a tumor is a very rare condition.
📊
Key Findings & Data:A 51-year-old female patient was admitted to our emergency department with complaints of vomiting, weight loss, and abdominal distension.
💡
Conclusion & Impact:In our case, it was determined that tumor bowel fistulization developed spontaneously even though it did not receive treatment, which is much rarer.
🔬Design:Olgu Sunumu
📍Scope:2015 Verileri
⚙️Variables:Tümör bağırsak fistülizasyonu · Gastrointestinal Stromal Tümör (GİST) · Akut İntestinal obstrüksiyon

Abstract

Intestinal fistulization into a tumor is a very rare condition. A 51-year-old female patient was admitted to our emergency department with complaints of vomiting, weight loss, and abdominal distension. A mass covering the entire pelvis, containing intestinal contents, and causing bowel obstruction was detected. With the participation of obstetricians and urologists, the patient was urgently operated on on June 5, 2015. It was determined that the tumoral mass infiltrated the bladder and fistulized into the small intestine. The mass was completely removed. Partial cystectomy and repair, partial small bowel resection, and end-to-end anastomosis were performed. The patient was discharged on the 10th postoperative day without any problems. Pathology revealed that the 18X15X11 cm mass was adherent to the small intestine in an area of 2.5 cm and had an area similar to the fistula mouth. The tumor had necrosis and nodularity in its middle region. The patient was diagnosed with a high-risk gastrointestinal stromal tumor (GIST). It has been determined that it originates from the jejunum wall, and invades the small intestine muscle layer and bladder serosa, and the outer muscle layer. The mitosis number was 5/50 BBA. In the literature, it has been reported that this type of tumor is rarely detected during the treatment of large GIST tumors. In our case, it was determined that tumor bowel fistulization developed spontaneously even though it did not receive treatment, which is much rarer. abdominal distension. A mass covering the entire pelvis, containing intestinal contents, and causing bowel obstruction was detected. With the participation of obstetricians and urologists, the patient was urgently operated on on June 5, 2015. It was determined that the tumoral mass infiltrated the bladder and fistulized into the small intestine. The mass was completely removed. Partial cystectomy and repair, partial small bowel resection, and end-to-end anastomosis were performed. The patient was discharged on the 10th postoperative day without any problems. Pathology revealed that the 18X15X11 cm mass was adherent to the small intestine in an area of 2.5 cm and had an area similar to the fistula mouth. The tumor had necrosis and nodularity in its middle region. The patient was diagnosed with a high-risk gastrointestinal stromal tumor (GIST). It has been determined that it originates from the jejunum wall, and invades the small intestine muscle layer and bladder serosa, and the outer muscle layer. The mitosis number was 5/50 BBA. In the literature, it has been reported that this type of tumor is rarely detected during the treatment of large GIST tumors. In our case, it was determined that tumor bowel fistulization developed spontaneously even though it did not receive treatment, which is much rarer.

Özet

Tümör içine barsak fistülizasyonu oldukça ender görülen bir durumdur. Olgumuz 51 yaşında kadın hasta kusma zayıflama ve karında şişlik şikayeti ile acil servisimize baş vurdu. Yapılan tetkikleri sonucunda tüm pelvisi kaplayan, bağırsak içeriği tümör içine fistülize olan ve barsak obstrüksiyonu yapan kitle tespit edildi. Kadın doğum ve üroloji uzmanlarının katılımı ile hasta 5.6.2015 tarihinde acil olarak ameliyata alındı. Tümöral kitlenin mesaneye infiltre ve incebağırsağa fistülize olduğu saptandı. Kitle total olarak çıkarıldı. Parsiyel sistektomi ve tamir,kısmi incebarsak rezeksiyonu ve uç uça anastomoz yapıldı. Hasta sorunsuz olarak postoperatif 10. gün taburcu edildi. Patolojik tetkikte 18X15X11 cm'lık kitle ince bağırsağa 2,5 cm lik bir alanda yapışık olduğu ve fistül ağzına benzer bir alan saptandı. Tümör orta bölgesinde nekroz ve nodüler yapıda idi. Yüksek riskli Gastrointestinal Stromal Tümör (GİST) tanısı konmuştur. Jejunum duvarından kaynaklandığı ince bağırsak kas tabakası ve mesane serozası ve dış kas tabakasına invaze olduğu saptanmıştır. Mitoz sayısı 5/50 BBA idi. Literatürde bu tip tümörlere ender olarak büyük GİST tümörlerinin tedavisi esnasında saptandığı bildirilmiştir. Olgumuzda ise çok daha ender görülen tedavi görmediği halde spontan olarak tümör barsak fistülizasyonu geliştiği saptanmıştır. Bu çalışmamızda büyük GİST tümörlerinde bağırsak fistülizasyonunun çok ender olsa da görülebileceği vurgulandı.

🔖

Cite This Article

Aren, A., Aksoy, Ş., Paşaoğlu, E., Yardımcı, A. H., Akay, A. F., Sevinç, M. M. (2025). A case of Gastrointestinal Stromal Tumor Intestinal Fistula causing intestinal obstruction. Istanbul Kent University Journal of Health Sciences, Cilt: 4 Sayı: 1, 20–24. https://ajindex.com/articles/1629781

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Bonvalot S, Eldweny H, Péchoux CL, et al.(2006) Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era. Ann Surg Oncol. 13(12):1596–603.
  2. Chow H1, Jung A, Talbott J, Lin AM, Daud AI, Coakley FV.(2011)Tumor fistulization associated with targeted therapy: computed tomographic findings and clinical consequences. J Comput Assist Tomogr. Jan-Feb;35(1):86-90.
  3. Demetri GD, von Mehren M, Antonescu CR, et al.(2010) NCCN Task Force report: Update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Cancer Netw. 2010;8(Suppl 2):S1–41.
  4. Gorelik M, Sabates B, Elkbuli A, Dunne T. (2018)Ileal gist presenting with bacteremia and liver abscess: A case report and review of literature. Int J Surg Case Rep. 42:261–5.
  5. Jankowska-Lombarska, M., Grabowska-Derlatka, L., & Derlatka, P. (2022). Tumor-Bowel Fistula as a Rare Form of Recurrent Ovarian Cancer—Imaging and Treatment: Preliminary Report. Current Oncology, 30(1), 506-517.
  6. Joensuu H, Hohenberger P, Corless CL. (2013) Gastrointestinal stromal tumor. Lancet. 20382(9896)
  7. Ng EK, Wong SK, Mok TS, Chan WY, Chung SC.(2003) Imatinib (STI-571) heals a gastrocutaneous fistula resulting from a malignant gastric stromal tumor. Gastric Cancer. 2003;6(2):122–6.
  8. Sunkara, N., Selig, T., Elfanagely, Y., & Sepe, T. E. (2023). Gastrointestinal Stromal Tumor Complicated by Fistula Formation. ACG Case Reports Journal, 10(11), e01195.