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Journals / EurAsian Journal of Oral and Maxillofacial Surgery / 2026 / Volume: 4 Issue: 1

Zimmermann-Laband Syndrome: A Case Report

Zimmermann-Laband Syndrome: Vaka Raporu

Gürkan Raşit Bayar(UNIVERSITY OF KYRENIA, FACULTY OF DENTISTRY)0000-0003-4119-9629
Kerim Ortakoğlu(Pırıl Dent İmplant Merkezi)0009-0009-4325-7061
H. Aykut Özyiğit(UNIVERSITY OF KYRENIA, FACULTY OF DENTISTRY)0009-0007-8488-6564
Pages
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Publication Date
2025-01-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Comprehensive evaluation and interdisciplinary management are essential for optimizing outcomes in ZLS patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Zimmerman-Laband Syndrome (ZLS) is a rare genetic disorder characterized by gingival fibromatosis, craniofacial abnormalities, and limb deformities.
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Key Findings & Data:This case report describes a 21-year-old male presenting with classical and unique features of ZLS.
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Conclusion & Impact:Comprehensive evaluation and interdisciplinary management are essential for optimizing outcomes in ZLS patients.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Zimmerman-Laband syndrome · gingival fibromatosis · anterior open bite

Abstract

Zimmerman-Laband Syndrome (ZLS) is a rare genetic disorder characterized by gingival fibromatosis, craniofacial abnormalities, and limb deformities. This case report describes a 21-year-old male presenting with classical and unique features of ZLS. A male patient was referred for failure of anterior teeth eruption. Clinical examination revealed gingival fibromatosis, hypoplastic toenails, and a broad, flat nose. Additional findings included congenital curly toes and an anterior open bite. Radiographic evaluation identified multiple impacted and supernumerary teeth. The patient underwent extraction of carious and supernumerary teeth. Orthodontic and surgical interventions were planned for managing unerupted teeth and anterior open bite. This report expands the phenotypic spectrum of ZLS, describing previously unreported findings such as curly toes and hammer toes. Comprehensive evaluation and interdisciplinary management are essential for optimizing outcomes in ZLS patients.

Özet

Zimmerman-Laband Sendromu (ZLS), gingival fibromatozis, kraniofasiyal anormaliler ve uzuv deformiteleri ile karakterize edilen nadir bir genetik hastalıktır. Bu vaka raporu, ZLS'nin klasik ve özgün özellikleriyle başvuran 21 yaşında bir erkek hastayı tanımlamaktadır. Hasta, anterior dişlerin sürmemesi nedeniyle sevk edilmiştir. Klinik muayene, gingival fibromatozsiz, hipoplastik tırnaklar ve geniş, düz bir burun ile uyumluydu. Ek bulgular arasında doğuştan gelen kıvrımlı parmaklar ve anterior open-bite yer alıyordu. Radyografik değerlendirme, birden fazla gömülü ve süpernümerer dişi ortaya koymuştur. Hastanın çürük ve süpernümerer dişleri çekilmiştir. Sürmeyen dişler ve anterior open-bite için ortodontik ve cerrahi müdahaleler planlanmıştır. Bu rapor, ZLS'nin fenotipik spektrumunu genişleterek, daha önce bildirilmeyen kıvrımlı parmaklar ve çekiç parmaklar gibi bulguları tanımlamaktadır. ZLS hastalarında sonuçların iyileştirilmesi için kapsamlı bir değerlendirme ve multidisipliner yaklaşım gereklidir.

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Cite This Article

Bayar, G. R., Ortakoğlu, K., Özyiğit, H. A. (2025). Zimmermann-Laband Syndrome: A Case Report. EurAsian Journal of Oral and Maxillofacial Surgery, Volume: 4 Issue: 1. https://ajindex.com/articles/1629634

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References (22)

  1. Zimmermann KW. Über anomalien des ektoderms. Vierteljahresschrift für Zahnheilkunde. 1928;44:419-434.
  2. Laband PF, Habib G, Humphreys GS. Hereditary gingival fibromatosis – Report of an affected family with associated splenomegaly and skeletal and soft-tissue abnormalities. Oral Surg Oral Med Oral Path. 1964;17:339-351.
  3. Alavandar G: Elephantiasis gingivae: Report of an affected family with associated hepatomegaly, soft tissue and skeletal abnormalities. J All Ind Dent Assoc. 1965;37:349-353.
  4. Bakaeen G, Scully C. Hereditary gingival fibromatosis in a family with the Zimmermann-Laband syndrome. J Oral Pathol Med 1991;20:456-459.
  5. Chadwick B, Hunter B, Hunter L, Aldred M, Wilkie A. Laband syndrome: Report of two cases, review of the literature, and identification of additional manifestations. Oral Surg Oral Med Oral Pathol. 1994;78:57-63. 6. Ili’na JG, Lurie JV, Vaslianskene JP. Analysis of phenotypic variability of Zimmermann-Laband syndrome. Pediatriia. 1988;4:86-88.
  6. Beemer FA. New syndromes: Part II: “European” syndromes. Am J Med Genet Supp. 1988;4:71-84.
  7. Bazoupoulou-Kyrkanidou E, Papagianoulis L,Papanicolaou S, et al: Laband syndrome: A case report. J Oral Pathol Med. 1990;19:385-387.
  8. Jacoby NM, Ripman HA, Munden JM. Partial anonychia (recessive) with hypertrophy of the gums and multiple abnormalities of the osseous system: Report of case. Guys Hosp Rep. 1940;90:34-40.
  9. Anatasov D, Kavlakov P, Penev P. Congenital idiopathic gingival fibromatosis combined with anichia. Stomatologija (Sofija). 1979;61:29-33.
  10. Oikawa K, Cavaglia MV, Lu D. Laband syndrome: Report of a case. J Oral Surg. 1979;37:120-122.
  11. Chodirker BN, Chudley AE, Toffler MA, Reed MH. Zimmermann- Laband syndrome and profound mental retardation. Am J Med Genet. 1986;25:543-547.
  12. Pina Neto JM, Soares LMN, Souza AHO. A new case of Zimmermann-Laband syndrome with mild mental retardation, asymmetry of limbs, and hypertrichosis. Am J Med Genet. 1988;31:691-695.
  13. Pfeiffer RA, Seemanova E, Süss J, Müssig D, Tietze HU. Das syndrom von Zimmermann-Laband. Klin Pediatr. 1992;204:1-5.
  14. Koch P, Wettstein A, Knauber J, Zaun H. A new case of Zimmermann-Laband syndrome with atypical retinitis pigmentosa. Acta Derm Venereol (Stockh). 1992;72:376-379.
  15. Lacombe D, Bioulac-Sage P, Sibout M, Daussac E, Lesure F, Manchart JP et al. Congenital marked hypertrichosis and laband syndrome in a child: Overlap between the gingival fibromatosishypertrichosis and laband syndromes. Genet Counsel. 1994;5:251-256.
  16. Van Buggenhout GJCM, Brunner HG, Trommelen JCM, Hamel BC. Zimmermann-Laband syndrome in a patient with severe mental retardation. Genet Counsel. 1995;6:321-327.
  17. Robertson SP, Lipp H, Bankier A. Zimmermann-Laband syndrome in an adult. Long-term follow-up of a patient with vascular and cardiac complications. Am J Med Genet. 1998;78:160-164.
  18. Dumic M, Crawford C, Ivkovic I, Cvitanovic M, Batinica S. Zimmermann-Laband syndrome: An unusually early presentation in a newborn girl. Croat Med J. 1999;40:102-103.
  19. Stefanova M, Atanassov D, Krastev T, Fuchs S, Kutsche K. Zimmermann-Laband syndrome associated with a balanced reciprocal translocation t(3;8)(p21.2;q24.3) in mother and daughter: molecular cytogenetic characterization of the breakpoint regions. Am J Med Genet A. 2003;15;117A(3):289-294.
  20. Hoogendijk CF, Marx J, Honey EM, Pretorius E, Christianson AL. Ultrastructural investigation of Zimmermann-Laband syndrome. Ultrastruct Pathol. 2006;30(6):423-6.
  21. Shirian S, Shahabinejad H, Saeedzadeh A, Daneshbod K, Khosropanah H, Mortazavi M et al. Zimmermann- Laband Syndrome: Clinical and Cytogenic study in Two Related Patients. J Clin Exp Dent. 2019;11(5):e452-6.
  22. Kshirsagar JT, Dharani K, Thangavel P. Zimmermann–Laband syndromeassociated hereditary gingival fibromatosis. J Indian Soc Periodontol 2023;27:645-50.