Journals / EurAsian Journal of Oral and Maxillofacial Surgery / 2026 / Volume: 5 Issue: 3

Rare Intraoral White Spongeous Nevus: A Case Report

Nadir Oral Beyaz Sünger Nevüsü: Bir Olgu Sunumu

Şamil Esad Güven(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ)0009-0006-5911-9446
Emre Balaban(YILDIRIM BEYAZIT UNIVERSITY)0000-0001-5399-2152
Mert Karabağ(RECEP TAYYIP ERDOGAN UNIVERSITY)0000-0003-1387-4367
Eren Kütük(RECEP TAYYIP ERDOGAN UNIVERSITY)0009-0002-1999-0107
Pages
—
Publication Date
2026-09-27
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

At the follow-up visits, although a subjective reduction in lesion thickness was observed based on intraoral examination and comparison of serial photographs, no definitive conclusion can be drawn regarding treatment efficacy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:White sponge nevus (WSN) is a rare autosomal dominant hereditary genodermatosis that predominantly affects non-keratinized mucosal surfaces.
📊
Key Findings & Data:Therefore, in order to establish an accurate diagnosis, histopathological evaluation is required in addition to anamnesis and clinical findings.
💡
Conclusion & Impact:At the follow-up visits, although a subjective reduction in lesion thickness was observed based on intraoral examination and comparison of serial photographs, no definitive conclusion can be drawn regarding treatment efficacy.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:White sponge nevus · autosomal dominant · white plaque

Abstract

White sponge nevus (WSN) is a rare autosomal dominant hereditary genodermatosis that predominantly affects non-keratinized mucosal surfaces. It is characterized by bilateral, thickened white plaques on the oral mucosa and may clinically resemble other white lesions. Therefore, in order to establish an accurate diagnosis, histopathological evaluation is required in addition to anamnesis and clinical findings. A male patient in his thirties presented to our clinic with complaints of widespread lesions in the oral cavity. Intraoral examination revealed asymptomatic white plaques, particularly prominent on the bilateral buccal mucosa. Based on the clinical and histopathological findings, the patient was diagnosed with WSN. The patient was treated with a 0.25% tetracycline mouth rinse for 12 weeks. At the follow-up visits, although a subjective reduction in lesion thickness was observed based on intraoral examination and comparison of serial photographs, no definitive conclusion can be drawn regarding treatment efficacy.

Özet

Beyaz sünger nevüsü (WSN), başlıca keratinize olmayan mukozal yüzeyleri etkileyen, nadir görülen otozomal dominant kalıtsal bir genodermatozdur. Oral mukozada bilateral, kalınlaşmış beyaz plaklarla karakterizedir ve klinik olarak diğer beyaz lezyonlara benzerlik gösterebilir. Bu nedenle doğru tanının konulabilmesi için anamnez ve klinik bulguların yanı sıra histopatolojik değerlendirme gereklidir. Otuzlu yaşlarda erkek hasta, ağız boşluğunda yaygın lezyonlar şikâyetiyle kliniğimize başvurdu. İntraoral muayenede, özellikle bilateral bukkal mukozada belirgin asemptomatik beyaz plaklar gözlendi. Klinik ve histopatolojik bulgular doğrultusunda hastaya WSN tanısı konuldu. Hastaya 12 hafta süreyle %0,25’lik tetrasiklin gargara tedavisi uygulandı. Takip randevularında, intraoral muayene ve seri fotoğrafların karşılaştırılması sonucunda lezyon kalınlığında subjektif bir azalma gözlenmiş olmakla birlikte, tedavi etkinliği hakkında kesin bir sonuca varılamamıştır.

🔖

Cite This Article

Güven, Ş. E., Balaban, E., Karabağ, M., Kütük, E. (2026). Rare Intraoral White Spongeous Nevus: A Case Report. EurAsian Journal of Oral and Maxillofacial Surgery, Volume: 5 Issue: 3. https://doi.org/10.66702/ejoms.1934793

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Aghbali A, Pouralibaba F, Eslami H, Pakdel F, Jamali Z. White sponge nevus: a case report. J Dent Res Dent Clin Dent Prospects.2009;3(2):70-72. doi:10.5681/joddd.2009.017.
  2. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders Elsevier;2009.
  3. Liu X, Li Q, Gao Y, Song S, Hua H. Mutational analysis in familial and sporadic patients with white sponge naevus. Br J Dermatol.2011;165(2):448-451. doi:10.1111/j.1365-2133.2011.10404.x.
  4. Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th ed. St. Louis: Elsevier; 2016.
  5. Jorgenson RJ, Levin LS. White sponge nevus. Arch Dermatol.1981;117(2):73-76. doi:10.1001/archderm.1981.01650020015015.
  6. Sanjeeta N, Nandini DB, Premlata T, Banerjee S. White sponge nevus: report of three cases in a single family. J Oral Maxillofac Pathol. 2016;20(2):300-303. doi:10.4103/0973-029X.185915.
  7. Otobe IF, de Sousa SOM, Matthews RW, Migliari DA. White sponge naevus: improvement with tetracycline mouth rinse: report of four cases. Clin Exp Dermatol. 2007;32(6):749-751. doi:10.1111/j.1365-2230.2007.02538.x.
  8. Shibuya Y, Zhang J, Yokoo S, Umeda M, Komori T. Constitutional mutation of keratin 13 gene in familial white sponge nevus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(5):561-565. doi:10.1016/S1079-2104(03)00372-X.
  9. Terrinoni A, Rugg EL, Lane EB, Melino G, Felix DH, Munro CS, et al. A novel mutation in the keratin 13 gene causing oral white sponge nevus. J Dent Res. 2001;80(3):919-923. doi:10.1177/00220345010800031401.
  10. Martins Filho PRS, Brasileiro BF, Piva MR, Trento CL, Santos TS. Familial case of oral white sponge nevus—a rare hereditary condition. An Bras Dermatol. 2011;86(4 Suppl 1):S39-S41.doi:10.1590/S0365-05962011000700009.
  11. de Haseth SB, Bakker E, Vermeer MH, El Idrissi H, Bosse T, Smit VTHBM, et al. A novel keratin 13 variant in a four-generation family with white sponge nevus. Clin Case Rep. 2017;5(9):1503-1509. doi:10.1002/ccr3.1073.
  12. Kürklü E, Öztürk Ş, Cassidy AJ, Ak G, Koray M, Çefle K, et al. Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus. Med Oral Patol Oral Cir Bucal. 2018;23(2):e144-e150. doi:10.4317/medoral.21437.
  13. McGinnis JP Jr, Turner JE. Ultrastructure of the white sponge nevus. Oral Surg Oral Med Oral Pathol. 1975;40(5):644-651.doi:10.1016/0030-4220(75)90374-6.
  14. McDonagh AJ, Gawkrodger DJ, Walker AE. White sponge naevus successfully treated with topical tetracycline. Clin Exp Dermatol.1990;15(2):152-153. doi:10.1111/j.1365-2230.1990.tb02056.x.
  15. Downham TF, Plezia RA. Oral squamous-cell carcinoma within a white-sponge nevus. J Dermatol Surg Oncol. 1978;4(6):470-472.doi:10.1111/j.1524-4725.1978.tb00476.x.
  16. Liu D, Zhang T, Zhou H, Wu C, Li T, Jiang L. Malignant transformation of white sponge nevus: a case report of a novel keratin 4 mutation. BMC Oral Health. 2024;24:588. doi:10.1186/s12903-024-04300-y.