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Journals / NanoEra / 2022 / Volume: 2 Issue: 2

Protein nanoparticle interaction

Nagihan Faydalı(SELCUK UNIVERSITY)0000-0002-8895-1825
Journal
NanoEra
Pages
—
Publication Date
2022-12-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, the factors affecting the protein nanoparticle interaction and the analysis methods of the resulting PC form are briefly mentioned.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:With the rapid development of nanotechnology in recent years, nanoparticles (NPs) have started to be used in the pharmaceutical industry for imaging, treatment and diagnosis.
📊
Key Findings & Data:For the use of NPs in drug delivery, it is necessary to clearly determine how nanoparticle-based drugs will behave in the biological environment.
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Conclusion & Impact:In this review, the factors affecting the protein nanoparticle interaction and the analysis methods of the resulting PC form are briefly mentioned.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Interaction · Nanoparticle · Nanotechnology

Abstract

With the rapid development of nanotechnology in recent years, nanoparticles (NPs) have started to be used in the pharmaceutical industry for imaging, treatment and diagnosis. For the use of NPs in drug delivery, it is necessary to clearly determine how nanoparticle-based drugs will behave in the biological environment. After these drugs enter the biological environment, they interact rapidly with the proteins in the biological environment and forming a complex called Protein Corona (PC). The formation of the PC form affects many important events such as the adsorption and distribution of drugs, whether the drug reaches the target area, and the removal of the drug from the body. In order to design a more safety nanoparticle-based drug, the interaction of NPs with protein should be well understood, the physicochemical properties of the resulting PC form and its behavioral characteristics in the biological environment should be clearly clarified. In this review, the factors affecting the protein nanoparticle interaction and the analysis methods of the resulting PC form are briefly mentioned.

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Cite This Article

Faydalı, N. (2022). Protein nanoparticle interaction. NanoEra, Volume: 2 Issue: 2. https://ajindex.com/articles/1627682

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References (16)

  1. Li, Y.; Lee, J.S.; Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona. Materials. 2020, 13, 3093; doi:10.3390/ma13143093
  2. Najahi-Missaoui, W.; Arnold, R.D.; Cummings, B.S. Safe Nanoparticles: Are We There Yet?. Int. J. Mol. Sci. 2021, 22, 385-406, doi: 10.3390/ijms22010385
  3. Kopp, M.; Kollenda, S.; Epple, M. Nanoparticle−Protein Interactions: Therapeutic Approaches and Supramolecular Chemistry. Accounts of Chemical Research. 2017, 50, 1383-1390, doi: 10.1021/acs.accounts.7b00051
  4. Mahmoudi, M.; Lynch, I.; Ejtehadi, M.R.; Monopoli M.P.; Bombelli, F.B.; Lauren, S. ProteinNanoparticle Interactions: Opportunities and Challenges. Chem. Rev. 2011, 111, 5610–5637, doi:10.1021/cr100440g
  5. Kopac, T. Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review. International Journal of Biological Macromolecules. 2021,169, 290–301, doi: 10.1016/j.ijbiomac.2020.12.108
  6. Mahmoudi, M.; Simchi, A.; Imani, M.; Shokrgozar, M.A.; Milani, A.S.; Häfeli, U.O.; Stroeve, P. A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. Colloids and Surfaces B: Biointerfaces. 2010,75, 300–309, doi:10.1016/j.colsurfb.2009.08.044
  7. Klein. J. Probing the interactions of proteins and nanoparticles.
  8. García-Álvarez, R.; Vallet-Regí, M. Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance. Nanomaterials, 2021, 11, 888-914, doi:10.3390/nano110408887
  9. Cox, M. C.; Barnham, K. J.; Frenkiel, T. A.; Hoeschele, J. D.; Mason, A. B.; He, Q. Y.; Woodworth, R. C.; Sadler, P. J. J. Biol. Inorg. Chem, 1999, 4, 621-631, doi: 10.1007/s007750050386.
  10. Yu. Y.; Luan. Y.; Dai. W. Dynamic process, mechanisms, influencing factors and study methods of protein corona formation. International Journal of Biological Macromolecules. 2022,205,731–739, doi: 10.1016/j.ijbiomac.2022.03.105
  11. A. Gessner, A. Lieske, B.R. Paulke, R.H. Müller, Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by twodimensional electrophoresis. Eur. J. Pharm. Biopharm, 2002,54, 165–170, doi: 10.1016/s0939-6411(02)00081-4.
  12. F. Alexis, E. Pridgen, L.K. Molnar, O.C. Farokhzad, Factors affecting the clearance and biodistribution of polymeric nanoparticles, Mol. Pharm. 2008, 505–515, doi: 10.1021/mp800051m
  13. C.A. Haynes, W. Norde, Globular proteins at solid/liquid interfaces, Colloids Surf. B: Biointerfaces, 1994, 2, 517–566, doi: 10.1016/0927-7765(94)80066-9
  14. S.T. Yang, Y. Liu, Y.W. Wang, A. Cao, Biosafety and bioapplication of nanomaterials by designing protein-nanoparticle interactions. Small 2013, 9, 1635–1653, doi: 10.1002/smll.201201492.
  15. Carrillo-Carrion. C.; Carril. M.; Parak. W.J. Techniques for the experimental investigation of the protein corona. Curr Opin Biotechnol, 2017, 46, 106-113, doi: 10.1016/j.copbio.2017.02.009. 16. Casalini. T.; Limongelli. V.; Schmutz. M.; Som. C.; Jordan. O.; Wick. P.; Borchard. G.; Perale. G. Molecular Modeling for Nanomaterial–Biology Interactions: Opportunities, Challenges, and Perspectives. Front. Bioeng. Biotechnol, 2019, 17, 268-282, doi:10.3389/fbioe.2019.00268
  16. Ding. H.; Ma.Y.; Computer simulation of the role of protein corona in cellular delivery of nanoparticles. Biomaterials,2014, 35, 8703-8710, doi:10.1016/j.biomaterials.2014.06.033